{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:16:22Z","timestamp":1786990582682,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T00:00:00Z","timestamp":1324339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To determine whether supplementation with vitamin B\n                      <jats:sub>6<\/jats:sub>\n                      improves nausea and\/or vomiting in pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This experimental study was conducted with 60 pregnant women experiencing nausea and\/or vomiting prior to the 12th gestational week. Of these women, 30 were treated daily with 10 mg and the remaining 30 with 1.28 mg of pyridoxine hydrochloride for 2 weeks. The primary outcome was the Pregnancy\u2010Unique Quantification of Emesis and Nausea (PUQE) score in each group at the end of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The women experiencing nausea and\/or vomiting in pregnancy had significantly lower levels of circulating vitamin B\n                      <jats:sub>6<\/jats:sub>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.007) compared with those without this symptom. Vitamin B\n                      <jats:sub>6<\/jats:sub>\n                      supplementation significantly increased plasma vitamin B\n                      <jats:sub>6<\/jats:sub>\n                      concentration (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05 in both groups). There were no significant differences in PUQE score or in plasma concentration levels of protein, dopamine, serotonin, unconjugated estriol, and ghrelin after supplementation between the 2 groups at baseline, but there was a significantly lesser decrease in PUQE score and a greater increase in vitamin B\n                      <jats:sub>6<\/jats:sub>\n                      level and vitamin B\n                      <jats:sub>6<\/jats:sub>\n                      concentration to plasma protein concentration ratios in group 1 than in group 2 after supplementation (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although the high\u2010supplementation group had a greater decrease in PUQE score in comparison to the low\u2010supplementation group, the difference is unlikely to affect the severity of symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2011.09.030","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T04:54:35Z","timestamp":1324356875000},"page":"206-210","source":"Crossref","is-referenced-by-count":28,"title":["Vitamin B\n                    <sub>6<\/sub>\n                    supplementation in pregnant women with nausea and vomiting"],"prefix":"10.1002","volume":"116","author":[{"given":"Noroyono","family":"Wibowo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuditiya","family":"Purwosunu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Sekizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Tambunan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saptawati","family":"Bardosono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90337-6"},{"issue":"8","key":"e_1_2_6_3_2","first-page":"39S","article-title":"Central mechanisms of vomiting","volume":"44","author":"Miller A.D.","year":"1999","journal-title":"Dig Dis Sci"},{"issue":"5","key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/jn\/114.5.977","article-title":"Effect of maternal pyridoxine X HCl supplementation on the vitamin B\u20106 status of mother and infant and on pregnancy outcome","volume":"114","author":"Schuster K.","year":"1984","journal-title":"J Nutr"},{"issue":"1","key":"e_1_2_6_5_2","first-page":"33","article-title":"Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double\u2010blind placebo\u2010controlled study","volume":"78","author":"Sahakian V.","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610500060651"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-536X.1992.tb00671.x"},{"key":"e_1_2_6_8_2","first-page":"54","volume-title":"Variation in rates of hospitalization for excessive vomiting in pregnancy by Bendectin\/Diclectin use in Canada","author":"Neutel C.I.","year":"2000"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200304000-00006"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00307.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.04.026"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(42)90598-2"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729211006096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729211006096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2011.09.030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2011.09.030","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2011.09.030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:28:21Z","timestamp":1696498101000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2011.09.030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,20]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1016\/j.ijgo.2011.09.030"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2011.09.030","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,20]]}}}