{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:17:21Z","timestamp":1758122241482,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,4,6]],"date-time":"2012-04-06T00:00:00Z","timestamp":1333670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To address the consequences of surgical curettage following failed medical abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case\u2013control study was performed in a tertiary gynecologic department. The case group comprised 104 women who underwent surgical curettage following failed medical abortion; the control group included 104 women who underwent early surgically induced abortion. Clinical characteristics and surgical findings were examined. The extent of inflammation was quantified following immunohistochemical staining for cell\u2010surface markers characteristic of T lymphocytes, B lymphocytes, and macrophages. The extent of necrosis was evaluated morphologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abnormal findings during surgical curettage were significantly more prevalent among women in the case group than in the control group (10.6% versus 1.9%; <jats:italic>P<\/jats:italic> = 0.019). The most frequent abnormality in the case group was the presence of intimately adherent products of conception, necessitating sharp curettage. The extent of inflammation (represented by increased numbers of T and B lymphocytes) was greater in the case group than in the control group (<jats:italic>P<\/jats:italic> = 0.046 and <jats:italic>P<\/jats:italic> = 0.001, respectively), as was the extent of necrosis (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Curettage following failed medical abortion harbors particular difficulties, which may be attributed to an inflammatory response. The long\u2010term consequences of curettage following failed medical abortion warrant further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.01.018","type":"journal-article","created":{"date-parts":[[2012,4,6]],"date-time":"2012-04-06T12:36:17Z","timestamp":1333715777000},"page":"234-238","source":"Crossref","is-referenced-by-count":2,"title":["Clinical, surgical, and histopathologic outcomes following failed medical abortion"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5128-0941","authenticated-orcid":false,"given":"Noga","family":"Fuchs Weizman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Maymon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ido","family":"Ben\u2010Ami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Mendlovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moty","family":"Pansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reuvit","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,6]]},"reference":[{"issue":"1","key":"e_1_2_6_2_2","first-page":"19","article-title":"Clinical study on the termination of 388 high\u2010risk early pregnancies with mifepristone and misoprostol","volume":"9","author":"Gao P.P.","year":"1998","journal-title":"Reprod Contracept"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.04.030"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2002.02156.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016340701203632"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh041"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2004.00368.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20232"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(03)00175-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000124782.69622.48"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.6.541"},{"issue":"4","key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1447-0756.1989.tb00203.x","article-title":"RU 486 mediated leukocytic inflammatory reaction at the utero\u2010placental interface","volume":"15","author":"Sinosich M.J.","year":"1989","journal-title":"Asia Oceania J Obstet Gynecol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070445"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000287291.19230.ba"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(99)00016-5"},{"issue":"1","key":"e_1_2_6_16_2","first-page":"CD003037","article-title":"Medical versus surgical methods for first trimester termination of pregnancy","volume":"25","author":"Say L.","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2009.28.3.295"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den426"}],"container-title":["International Journal of Gynecology &amp; 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