{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T05:23:28Z","timestamp":1730957008012,"version":"3.28.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:00:00Z","timestamp":1337126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the strategy of \u201csee and treat\u201d by loop electrosurgical excision procedure (LEEP) for cytologic high\u2010grade precancerous cervical lesions (squamous intraepithelial lesions; HSIL) and post\u2010LEEP recurrence among low\u2010income Brazilian women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective survey of women who underwent LEEP for cytologic HSIL without prior cervical biopsy between January 2004 and March 2008 at CISVALI, Uni\u00e3o da Vit\u00f3ria, Paran\u00e1, Brazil, LEEP sample histology and patient follow\u2010up by Papanicolaou smear were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 117 women treated, 24% had no lesions, 67.5% had cervical intraepithelial neoplasia (CIN) grade 2\/3, and 5.2% had squamous cell carcinoma or adenocarcinoma on LEEP histology. Among patients with follow\u2010up, recurrences occurred in those with no lesions (16.7%) and CIN 2\/3 (25%) (<jats:italic>P<\/jats:italic> &gt; 0.05). HSIL was the most frequent type of recurrence (87%) (<jats:italic>P<\/jats:italic> &lt; 0.001). In total, 6.3% of patients had positive ectocervical (ecto\u2010positive) and endocervical (endo\u2010positive) margins, 3.8% had ecto\u2010positive, and 33.0% had endo\u2010positive margins. Recurrences occurred in women with endo\u2010positive (26.3%), no margin (17.4%), and cautery artifact margin (25.0%) involvement (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For cytologic HSIL, the benefits of the strategy of \u201csee and treat\u201d by LEEP outweighed the risk of overtreatment. Patients with both positive and negative margins on LEEP should be followed carefully.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.02.017","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T11:43:59Z","timestamp":1337168639000},"page":"103-106","source":"Crossref","is-referenced-by-count":8,"title":["The \u201csee and treat\u201d strategy for identifying cytologic high\u2010grade precancerous cervical lesions among low\u2010income Brazilian women"],"prefix":"10.1002","volume":"118","author":[{"given":"Paula R.B.","family":"Nogara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds A.R.","family":"Manfroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana C.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia E.L.","family":"Consolaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,16]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_2","DOI":"10.1007\/s00404-009-1298-3"},{"volume-title":"Bethesda System for Cervicovaginal Cytology: Definitions, Criteria and Explanatory Notes","year":"2005","author":"Solomon D.","key":"e_1_2_6_3_2"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_2","DOI":"10.1067\/mob.2003.282"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_2","DOI":"10.1016\/S0002-9378(11)90622-X"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_2","DOI":"10.1006\/gyno.2000.5825"},{"issue":"3","key":"e_1_2_6_7_2","first-page":"213","article-title":"Nomenclature for cervical reports and approaches recommended: recommendations for health professionals","volume":"52","author":"Brazilian Ministry of Health","year":"2006","journal-title":"Rev Bras Cancerol"},{"issue":"3","key":"e_1_2_6_8_2","first-page":"253","article-title":"\u2018See and treat\u2019 electrosurgical loop excision of the cervical transformation zone","volume":"42","author":"Ferris D.G.","year":"1996","journal-title":"J Fam Pract"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_2","DOI":"10.1111\/j.1447-0756.2008.00992.x"},{"unstructured":"National Institute of Cancer\/Brazil.Estimation of Cancer in Brazil in 2010.http:\/\/www1.inca.gov.br\/vigilancia\/incidencia.html. 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