{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:57:03Z","timestamp":1781657823034,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T00:00:00Z","timestamp":1339113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the potential advantages of combined mifepristone\u2013misoprostol versus misoprostol\u2010only for early medical abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind randomized placebo controlled study was conducted that enrolled 441 pregnant women (&lt; 63 days since last menstrual period) at 2 hospitals in Tunisia and Vietnam. The mifepristone\u2013misoprostol group (n = 220) received 200 mg of mifepristone on day 1 and 800 \u03bcg buccal misoprostol followed by placebo 3 hours later on day 2. The misoprostol\u2010only group (n = 221) received placebo on day 1 and 1600 \u03bcg of misoprostol (2 doses of 800 \u03bcg, given 3 hours apart) on day 2. All medications were self\u2010administered at home with follow\u2010up 1 week later. The primary outcome was complete uterine evacuation without surgical intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Successful uterine evacuation occurred for 78.0% (n = 170) of women with misoprostol only versus 92.9% (n = 195) of women with mifepristone\u2013misoprostol (relative risk 0.84, 95% CI, 0.78\u20130.91; <jats:italic>P<\/jats:italic> &lt; 0.001). Ongoing pregnancy occurred for 13.8% (n = 30) of women given misoprostol\u2010only and 1.4% (n = 3) of women given mifepristone\u2013misoprostol (relative risk 9.63, 95% CI 2.98\u201331.09; <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mifepristone plus misoprostol is significantly more effective than misoprostol\u2010only for early medical abortion.<\/jats:p><jats:p><jats:bold>Clinical<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/trials.gov\">trials.gov<\/jats:ext-link> <jats:bold>registration number: NCT00680394<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.03.039","type":"journal-article","created":{"date-parts":[[2012,6,9]],"date-time":"2012-06-09T00:15:57Z","timestamp":1339200957000},"page":"166-171","source":"Crossref","is-referenced-by-count":39,"title":["Comparison of misoprostol\u2010only and combined mifepristone\u2013misoprostol regimens for home\u2010based early medical abortion in Tunisia and Vietnam"],"prefix":"10.1002","volume":"118","author":[{"given":"Jennifer","family":"Blum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Raghavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Dabash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen thi Nhu","family":"Ngoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9la","family":"Chelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma","family":"Hajri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Conkling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly","family":"Winikoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,8]]},"reference":[{"issue":"4","key":"e_1_2_6_2_2","first-page":"871","article-title":"ACOG practice bulletin. 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