{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:30:37Z","timestamp":1783071037018,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T00:00:00Z","timestamp":1340064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review case reports of hepatic hematoma\/rupture in women with pre\u2010eclampsia\/eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, SciELO, and LILACS databases were searched for case reports of pre\u2010eclampsia\/eclampsia with hepatic hematoma\/rupture. Only articles written in English, Spanish, French, or Portuguese and published between 1990 and 2010 were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 180 cases of hepatic hematoma or rupture were identified: 18 (10.0%) with subcapsular hematoma without hepatic rupture; and 162 (90.0%) with capsule rupture. Twelve (6.7%) cases were associated with eclampsia plus hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. Average age was 30.9 \u00b1 5.0 years, 74\/129 (57.4%) women were parous, and cesarean delivery was performed in 132\/162 (81.5%) cases. The right lobule was the most frequently affected 77\/100 (77.0%). The total maternal mortality rate was 22.2% during the 21 years; however, it decreased to 16.4% in the last decade studied. The perinatal mortality rate was 30.7% and was very similar during the 2 decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HELLP syndrome is a frequent diagnosis (92.8%) in hepatic hemorrhage\/rupture. The major reduction in maternal mortality rate was probably associated with advances in resuscitation, intensive\u2010care medicine, and surgical intervention, including liver transplantation and arterial embolization.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.03.042","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T04:45:58Z","timestamp":1340081158000},"page":"186-189","source":"Crossref","is-referenced-by-count":53,"title":["Pre\u2010eclampsia\/eclampsia and hepatic rupture"],"prefix":"10.1002","volume":"118","author":[{"given":"Paulino","family":"Vigil\u2010De Gracia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ortega\u2010Paz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.09.014"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsurg.2009.04.001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-008-0829-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00358-X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/0144361031000074583"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.016"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199903000-00024"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70343-1"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90266-8"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70022-0"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70216-X"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/10641950701826612"},{"issue":"2","key":"e_1_2_6_14_2","first-page":"149","article-title":"Eclampsia in Irrua Specialist Teaching Hospital: a five\u2010year review","volume":"13","author":"Okogbenin S.A.","year":"2010","journal-title":"Niger J Clin Pract"},{"issue":"5","key":"e_1_2_6_15_2","first-page":"209","article-title":"Post\u2010partum spontaneous hepatic rupture in eclampsia","volume":"20","author":"Singh K.N.","year":"2001","journal-title":"Indian J Gastroenterol"},{"issue":"4","key":"e_1_2_6_16_2","first-page":"133","article-title":"Spontaneous rupture of the liver associated with pregnancy. 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