{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:05:17Z","timestamp":1770678317532,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T00:00:00Z","timestamp":1342569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the incidence of spontaneous pregnancy reduction and early pregnancy complications among multiple pregnancies conceived via in vitro fertilization (IVF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Spontaneous pregnancy reduction was assessed among multiple pregnancies conceived after IVF treatment in a private assisted reproduction center in Lagos, Nigeria, between January 2008, and June 2011. The pregnancies were diagnosed at 6\u20138 weeks of gestation by ultrasound scan, which was repeated at 11\u201314 weeks to determine the incidence of spontaneous reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of multiple pregnancies was 35.2%. There were 11 (20.0%) twin, 6 triplet (10.5%), and 2 quintuplet (3.6%) pregnancies. Spontaneous reduction occurred in 9 (47.7%) of these pregnancies, including 15.8% of twins, 21% of triplets, and 10.5% of quintuplets. Spontaneous reduction was significant among triplets and quintuplets (<jats:italic>P<\/jats:italic> &lt; 0.05). Six women (31.5%) older than 36 years had spontaneous reduction (<jats:italic>P<\/jats:italic> &lt; 0.05). Vaginal bleeding occurred in 3 (15.5%) women, 2 (66.7%) of whom had spontaneous abortion. In all instances of monochorionic placentation, spontaneous reduction resulted in spontaneous abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of spontaneous reduction among multiple pregnancies conceived after IVF was high. Vaginal bleeding was a warning sign of eventual abortion. Early pregnancy complications were fewer among pregnancies with dichorionic and trichorionic placentation.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.05.021","type":"journal-article","created":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T20:02:30Z","timestamp":1342641750000},"page":"57-60","source":"Crossref","is-referenced-by-count":16,"title":["Spontaneous fetal reduction and early pregnancy complications in multiple pregnancies following in vitro fertilization"],"prefix":"10.1002","volume":"119","author":[{"given":"Olufemi A.","family":"Oloyede","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faye","family":"Iketubosin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kehinde","family":"Bamgbopa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,18]]},"reference":[{"issue":"5","key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1016\/j.fertnstert.2006.08.073","article-title":"Multiple pregnancy associated with infertility therapy","volume":"86","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2006","journal-title":"Fertil Steril"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.06.022"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1576\/toag.2000.2.4.4"},{"key":"e_1_2_6_5_2","unstructured":"Centers for Disease Control Prevention.Assisted Reproductive Technology Success Rates 1997: National Summary and Fertility Clinic Reports.http:\/\/www.cdc.gov\/nccdphp\/drh\/arts\/index.htm. Published 1999"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2004.10.009"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.105546"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.118915"},{"issue":"8","key":"e_1_2_6_9_2","first-page":"603","article-title":"Effect of spontaneous pregnancy reduction on obstetric outcome","volume":"50","author":"Steinkampf M.P.","year":"2005","journal-title":"J Reprod Med"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(98)00043-5"},{"issue":"1","key":"e_1_2_6_11_2","first-page":"67","article-title":"The new techniques of assisted reproduction","volume":"20","author":"Oloyede O.A.O.","year":"2003","journal-title":"Trop J Obstet Gynecol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.044"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.03.068"},{"key":"e_1_2_6_14_2","first-page":"7","volume-title":"First Trimester Diagnosis of Chromosomal Defects","author":"Snidjers R.","year":"2004"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970060105"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1430309"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)60614-3"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del054"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S002072921200330X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S002072921200330X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2012.05.021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2012.05.021","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2012.05.021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:26:08Z","timestamp":1696483568000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2012.05.021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,18]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1016\/j.ijgo.2012.05.021"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2012.05.021","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,18]]}}}