{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T21:50:19Z","timestamp":1771365019851,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,22]],"date-time":"2012-07-22T00:00:00Z","timestamp":1342915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Siriraj Research Development Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine incidence, originating organ, and factors predicting significant histopathology (premalignant and malignant lesions) among women with atypical glandular cells (AGCs) on liquid\u2010based cytology (LBC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective study at Siriraj Hospital, Bangkok, Thailand, clinical and histologic data were reviewed for women with AGCs who underwent appropriate examinations from January 2007 to December 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 284 women with AGC cytology (mean age, 51.2 years). The incidence of significant pathology and invasive cancer was 43.3% and 34.5%, respectively. The most common malignant organ was the uterus (64\/123, 52%). Predictors of serious pathology were AGC favor neoplasia (AGC\u2010FN) endocervical (odds ratio [OR], 5.64; 95% confidence interval [CI], 1.62\u201319.57), AGC\u2010FN endometrial (OR, 4.11; 95% CI, 1.27\u201313.32), AGC\u2010FN glandular (OR, 8.23; 95% CI, 2.02\u201333.49) subtypes, and bleeding (OR, 2.88; 95% CI, 1.47\u20135.65). Combining patient age and AGC subtype, there were no serious cervical lesions among women aged 50 years or younger with AGC\u2010FN glandular subtype, or serious non\u2010cervical neoplasia among women aged 50 years or younger with AGC not otherwise specified (AGC\u2010NOS) or AGC\u2010FN endocervical subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AGC subcategories defined from LBC, alone or combined with patient age, might be predictors of significant histopathology, cancer incidence, and originating organ.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.05.027","type":"journal-article","created":{"date-parts":[[2012,7,22]],"date-time":"2012-07-22T02:46:04Z","timestamp":1342925164000},"page":"30-34","source":"Crossref","is-referenced-by-count":13,"title":["Factors predicting pathologic significance among women with atypical glandular cells on liquid\u2010based cytology"],"prefix":"10.1002","volume":"119","author":[{"given":"Usanee","family":"Chatchotikawong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Ruengkhachorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somsak","family":"Laiwejpithaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2120"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3181585870"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.09.001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01387.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000218705.87329.4a"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.08.002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"issue":"2","key":"e_1_2_6_9_2","first-page":"51S","article-title":"Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults\u2014The Evidence Report. 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