{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:57:34Z","timestamp":1757703454169,"version":"3.40.3"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,8,25]],"date-time":"2012-08-25T00:00:00Z","timestamp":1345852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether rectally administered misoprostol can induce intestinal motility compared with oxytocin infusion when used to prevent primary postpartum hemorrhage after cesarean delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective randomized double\u2010blind study in Nigeria, 218 parturients undergoing cesarean delivery who had risk factors for primary postpartum hemorrhage were enrolled between July 1, 2010, and March 31, 2011. Participants received 600 \u03bcg of rectal misoprostol or 20 intravenous units of oxytocin for 4 hours after surgery. The primary outcome was time until passage of flatus. Adverse effects, need for additional analgesic, and length of hospital stay were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The misoprostol group had a significantly shorter mean postoperative interval to passage of flatus (20.27 \u00b1 7.77 hours versus 38.34 \u00b1 10.98 hours;<jats:italic>P<\/jats:italic>&lt; 0.001) and commencement of regular diet (21.08 \u00b1 7.69 hours versus 39.13 \u00b1 10.94 hours;<jats:italic>P<\/jats:italic>&lt; 0.001). Gastrointestinal adverse effects were more frequent, albeit not significantly, in the misoprostol group: nausea, 6.4% versus 1.8%; vomiting, 7.3% versus 2.8%; and abdominal distension, 3.7% versus 2.8%. The need for additional analgesic was the same in the 2 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After cesarean delivery, rectal misoprostol had the added benefit of inducing intestinal motility. Misoprostol might be considered in a clinical setting where postoperative ileus is anticipated.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.05.033","type":"journal-article","created":{"date-parts":[[2012,8,25]],"date-time":"2012-08-25T06:42:33Z","timestamp":1345876953000},"page":"159-162","source":"Crossref","is-referenced-by-count":6,"title":["The effect of post\u2010cesarean rectal misoprostol on intestinal motility"],"prefix":"10.1002","volume":"119","author":[{"given":"Abiodun I.","family":"Adanikin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest O.","family":"Orji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olusola B.","family":"Fasubaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uche","family":"Onwudiegwu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omotade A.","family":"Ijarotimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwaseyi","family":"Olaniyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,25]]},"reference":[{"issue":"8","key":"e_1_2_6_2_2","first-page":"448","article-title":"Uncomplicated Caesarean section: is prolonged hospital stay necessary?","volume":"77","author":"Fasubaa O.B.","year":"2000","journal-title":"East Afr Med J"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802430826"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01297029"},{"key":"e_1_2_6_5_2","first-page":"571","volume-title":"Novak's Gynecology","author":"Clarke\u2010Pearson D.L.","year":"1996"},{"key":"e_1_2_6_6_2","first-page":"142","volume-title":"Te Linde's Operative Gynecology","author":"Horowitz I.R.","year":"1997"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)90900-X"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087539"},{"issue":"2","key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0022-3565(25)23170-6","article-title":"Prostaglandin E2\u2010induced diarrhea in mice: importance of colonic secretion","volume":"256","author":"Rivi\u00e8re P.J.","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2007.00767.x"},{"volume-title":"Essential Medical Statistics","year":"2003","author":"Kirkwood B.R.","key":"e_1_2_6_11_2"},{"issue":"2","key":"e_1_2_6_12_2","first-page":"CD002855","article-title":"Medical methods for first trimester abortion","author":"Kulier R.","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.12.005"},{"issue":"4","key":"e_1_2_6_14_2","first-page":"837","article-title":"Epidural anesthesia and gastrointestinal motility","volume":"86","author":"Steinbrook R.A.","year":"1998","journal-title":"Anesth Analg"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00161-6"},{"issue":"5","key":"e_1_2_6_16_2","first-page":"968","article-title":"Pharmacokinetics and adverse\u2010effect profile of rectally administered misoprostol in the third stage of labor","volume":"101","author":"Khan R.U.","year":"2003","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08266.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05835-4"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117360"},{"issue":"3","key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1152\/jappl.1996.81.3.1312","article-title":"Influence of pregnancy on the febrile response to intracerebroventricular administration of PGE1 in rats","volume":"81","author":"Stobie\u2010Hayes K.M.","year":"1996","journal-title":"J Appl Physiol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(97)00244-0"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00049-X"},{"issue":"4","key":"e_1_2_6_23_2","first-page":"S11","article-title":"A comparative study of early postoperative feeding versus conventional feeding for patients undergoing cesarean section; a randomized controlled trial","volume":"89","author":"Chantarasorn V.","year":"2006","journal-title":"J Med Assoc Thai"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729212003475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729212003475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2012.05.033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2012.05.033","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2012.05.033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T07:42:33Z","timestamp":1744011753000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2012.05.033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,25]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1016\/j.ijgo.2012.05.033"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2012.05.033","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"type":"print","value":"0020-7292"},{"type":"electronic","value":"1879-3479"}],"subject":[],"published":{"date-parts":[[2012,8,25]]}}}