{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T14:56:55Z","timestamp":1776351415631,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T00:00:00Z","timestamp":1347667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/13\/88\/06\u2013NCD\u2013III"],"award-info":[{"award-number":["5\/13\/88\/06\u2013NCD\u2013III"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the prevalence of HPV infection among women with cervical cancer in Tiruchirapalli, Tamil Nadu, India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study was conducted with 246 women with cervical cancer and 257 control participants aged between 20 and 70 years. The presence of HPV DNA was determined using the MY09\/11 PCR protocol, the GP5<jats:sup>+<\/jats:sup>\/6<jats:sup>+<\/jats:sup> PCR protocol, and type\u2010specific PCR\u2010based assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall HPV prevalence was 54.9% and HPV 16 was the most prevalent type. The women the most vulnerable for HPV infection were those aged 41 to 60 years. The major contributing risk factors for cervical cancer were having had 3 or more pregnancies (OR 19.2; 95% CI, 10.78\u201310.16); harboring high\u2010risk HPV DNA (OR 15.3; 95% CI, 9.81\u201323.8); being a manual worker (OR 14.9; 95% CI, 9.62\u201323.08); being illiterate (OR 8.28; 95% CI, 5.51\u201312.43); and having never been screened for cervical dysplasia (OR 6.70; 95% CI, 10.78\u201334.44).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present report on the overall and type\u2010specific prevalence rates and risk burden of HPV infection in Tamil Nadu confirms that screening and vaccination programs are urgently needed in this state to overcome the burden of HPV\u2010associated cervical cancer.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.06.019","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T11:47:31Z","timestamp":1347709651000},"page":"253-256","source":"Crossref","is-referenced-by-count":20,"title":["Prevalence of high\u2010risk HPV and associated risk factors in cases of cervical carcinoma in Tamil Nadu, India"],"prefix":"10.1002","volume":"119","author":[{"given":"Krishnakumar","family":"Vinodhini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santhanam","family":"Shanmughapriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumathy","family":"Sanmugham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesan","family":"Senthikumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhudev C.","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalimuthusamy","family":"Natarajaseenivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.11.041"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.03.047"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.20.11172-11186.2004"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.24.3106"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"issue":"2","key":"e_1_2_6_7_2","first-page":"F55","article-title":"Papillomavirus infections\u2013\u2013a major cause of human cancers","volume":"1288","author":"zur Hausen H.","year":"1996","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"e_1_2_6_8_2","first-page":"765","article-title":"Activity and therapeutic potential of ORI\u20131001 antisense oligonucleotide on human papillomavirus replication utilizing a model of dysplastic human epithelium","volume":"25","author":"Alam S.","year":"2005","journal-title":"Anticancer Res"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2006.12.017"},{"issue":"3","key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/jcm.28.3.495-503.1990","article-title":"Rapid and simple method for purification of nucleic acids","volume":"28","author":"Boom R.","year":"1990","journal-title":"J Clin Microbiol"},{"issue":"4","key":"e_1_2_6_11_2","first-page":"231","article-title":"Detection of human papillomavirus DNA sequences in cancer of the urinary bladder by in situ hybridisation and polymerase chain reaction","volume":"71","author":"Gopalkrishna V.","year":"1995","journal-title":"Genitourin Med"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-9-2327"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.2.235"},{"key":"e_1_2_6_14_2","first-page":"131","volume-title":"Diagnostic Molecular Pathology: A Practical Approach","author":"Bauer H.M.","year":"1992"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199309000-00007"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-4-1057"},{"key":"e_1_2_6_17_2","first-page":"11","article-title":"High and low risk human papilloma virus infection in women with CIN. 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