{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:22:49Z","timestamp":1773760969114,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T00:00:00Z","timestamp":1347667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify morbidity and pregnancy outcomes associated with sickle cell disease (SCD) among pregnant Saudi women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 10\u2010year retrospective study was conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, that included 392 cases of SCD in pregnancy and 784 controls with normal hemoglobin phenotype, who were selected and matched for age, parity, and delivery outcome. The main outcome measures were morbidity, maternal outcomes, and fetal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of SCD was 1.1% among all deliveries, with 2 maternal deaths (0.5%) and a perinatal mortality rate of 77.7 per 1000 deliveries. The major maternal complications in the SCD group were anemia (86.2%); sickle cell crisis (64.8% overall, with 43.1% vaso\u2010occlusive, 21.2% hemolytic, and 0.5% sequestration or aplastic); bacterial infection (8.8%); preterm delivery (15.3%); and pre\u2010eclampsia (9.7%). Fetal growth restriction and stillbirths accounted for 65.6% of the perinatal mortality. Blood transfusion was indicated in 33.7% of pregnancies in the SCD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pregnant Saudi women with SCD are at increased risk for pregnancy\u2010related complications, as well as fetal morbidity and mortality. A critical need exists among Saudi hospitals for a multidisciplinary approach to the management of pregnancies complicated by SCD.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.07.008","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T11:47:10Z","timestamp":1347709630000},"page":"224-226","source":"Crossref","is-referenced-by-count":31,"title":["Morbidity and pregnancy outcomes associated with sickle cell anemia among Saudi women"],"prefix":"10.1002","volume":"119","author":[{"given":"Maryam A.","family":"Al Kahtani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"AlQahtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mashael M.","family":"Alshebaily","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abd Elzaher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Moawad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naji","family":"AlJohani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1169","volume-title":"Obstetrics: Normal and Problem Pregnancies","author":"Samuels P.","year":"2002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.07.003"},{"issue":"1","key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00006250-200701000-00055","article-title":"ACOG Practice Bulletin No. 78: hemoglobinopathies in pregnancy","volume":"109","author":"ACOG Committee on Obstetrics","year":"2007","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2004.03.006"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198602000-00012"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115477"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00367-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000127433.23611.54"},{"key":"e_1_2_6_10_2","unstructured":"Royal College of Obstetricians and Gynecologists.Management of Sickle Cell Disease in Pregnancy.http:\/\/www.rcog.org.uk\/womens\u2010health\/clinical\u2010guidance\/sickle\u2010cell\u2010disease\u2010pregnancy\u2010management\u2010green\u2010top\u201061 Published July 2011"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(71)90772-1"},{"issue":"2","key":"e_1_2_6_12_2","first-page":"96","article-title":"The pattern of sickle cell disease in pregnancy in Lagos, Nigeria","volume":"12","author":"Ogedengbe O.K.","year":"1993","journal-title":"West Afr J Med"},{"issue":"2","key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4103\/1117-1936.177482","article-title":"Pregnancy outcome in women with sickle cell \u2010 a five year review","volume":"14","author":"Omo\u2010Aghoja I.O.","year":"2007","journal-title":"Niger Postgrad Med J"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1002-7"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.02.007"},{"issue":"12","key":"e_1_2_6_16_2","first-page":"1455","article-title":"Pregnancy outcome in women with sickle cell trait","volume":"23","author":"Hamdi I.M.","year":"2002","journal-title":"Saudi Med J"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/37.3.100"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(92)90376-T"},{"issue":"7","key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1471-0528.1986.tb07973.x","article-title":"Pregnancy in Jamaican women with homozygous sickle cell disease. 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