{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T02:05:31Z","timestamp":1746065131004},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T00:00:00Z","timestamp":1348012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To understand the relationship between human papillomavirus (HPV) genotype distribution and cervical neoplasia among women with abnormal cytology in Beijing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a study in Beijing, China, participants underwent a gynecologic examination between September 2006 and December 2009. Those with abnormal cytology underwent colposcopy, biopsy, and HPV testing. HPV was typed by flow\u2010through hybridization on formalin\u2010fixed paraffin\u2010embedded tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 6339 women examined, 533 with abnormal cytology underwent HPV testing. The prevalence of high\u2010risk HPV (HR\u2010HPV) subtypes was 29.8%. HPV\u201016 was the most common genotype (12.8%), followed by HPV\u201033, HPV\u201058, HPV\u201066, HPV\u201018, and HPV\u201052. The cytologic and histopathologic grade clearly increased with a higher prevalence of HR\u2010HPV infection. Both HPV\u201016 and HPV\u201033 were significantly associated with grade CIN2 + lesions (<jats:italic>P<\/jats:italic> &lt; 0.05). By contrast, HPV\u201018 and HPV\u201066 were not associated with cervical lesion severity. HR\u2010HPV infection was most common among women aged 30\u201334 years (35.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HPV\u201016, HPV\u201058, HPV\u201033, HPV\u201066, HPV\u201018, and HPV\u201052 were the most common genotypes in Beijing. HPV\u201016 and HPV\u201033 might be associated with CIN2 + lesions. HPV\u201018 and HPV\u201066 were not associated with high\u2010grade cervical lesions. The present results might help to improve HPV vaccination and cervical cancer prevention programs in Beijing.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.07.011","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T11:45:21Z","timestamp":1348055121000},"page":"257-261","source":"Crossref","is-referenced-by-count":18,"title":["Distribution of human papillomavirus genotype and cervical neoplasia among women with abnormal cytology in Beijing, China"],"prefix":"10.1002","volume":"119","author":[{"given":"Ren","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caiyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,19]]},"reference":[{"issue":"12","key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay J.","year":"2010","journal-title":"Int J Cancer"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"issue":"3","key":"e_1_2_6_4_2","first-page":"99","article-title":"Review of 20 years of HPV research in Slovenia","volume":"20","author":"Poljak M.","year":"2011","journal-title":"Acta Dermatovenerol Alp Panonica Adriat"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"issue":"1","key":"e_1_2_6_6_2","first-page":"176","article-title":"A review of the natural history of cervical intraepithelial neoplasia","volume":"29","author":"Duggan M.A.","year":"2002","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.05.064"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2009.20.2.72"},{"key":"e_1_2_6_9_2","volume-title":"Tumors of the Cervix, Vagina, and Vulva","author":"Kurman R.J.","year":"1992"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.11.026"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032259"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2569"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31818f5008"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70158-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/428850"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2007.12.007"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.01024.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-66"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00783-10"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1804"},{"issue":"9686","key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0140-6736(09)61248-4","article-title":"Efficacy of human papillomavirus (HPV)\u201016\/18 AS04\u2010adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double\u2010blind, randomised study in young women","volume":"374","author":"Paavonen J.","year":"2009","journal-title":"Lancet"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e3e719"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605351"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70230-8"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.03.007"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-4179"}],"container-title":["International Journal of Gynecology &amp; 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