{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:06:48Z","timestamp":1760267208153},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T00:00:00Z","timestamp":1358899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43TW000010-21S1"],"award-info":[{"award-number":["D43TW000010-21S1"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effect of the time interval between cervical cytology screening and histology at treatment on grade of cervical disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective cross\u2010sectional study at a colposcopy clinic in Soweto, Johannesburg, South Africa, data were compared from women with cytologic abnormalities referred for colposcopy between April 2003 and June 2010 to determine whether early (\u2264 180 days) or late (&gt; 180 days) referral had an impact on dysplasia grade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the early and late referral groups, there were 213 (13.43%) and 201 (14.63%) women, respectively, with upgrading of cervical dysplasia (<jats:italic>P<\/jats:italic> = 0.35), and 1373 (86.57%) and 1173 (85.37%) women, respectively, with downgrading or no change (<jats:italic>P<\/jats:italic> = 0.35). Risk factors for upgrading were HIV infection (odds ratio [OR], 1.63; <jats:italic>P<\/jats:italic> &lt; 0.001) and condom use (OR, 1.30; <jats:italic>P<\/jats:italic> = 0.02). Four cases (0.68%) of invasion among women with low\u2010grade squamous intraepithelial lesion (LSIL) and 50 cases (2.11%) among women with high\u2010grade SIL (HSIL) were not detected by cytology. Risk factors for invasive disease on histology were age (OR, 1.09 per year; <jats:italic>P<\/jats:italic> &lt; 0.001), parity (OR, 1.32 per pregnancy; <jats:italic>P<\/jats:italic> &lt; 0.001), and HSIL on cytology (OR, 3.17; <jats:italic>P<\/jats:italic> = 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no difference in the up\u2010 or downgrading of cervical dysplasia between the 2 referral groups.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.09.022","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T20:32:05Z","timestamp":1358973125000},"page":"257-261","source":"Crossref","is-referenced-by-count":5,"title":["Effect of 2 referral intervals on diagnostic discordance between cytology and histology at a colposcopy clinic"],"prefix":"10.1002","volume":"120","author":[{"given":"Francois","family":"Saayman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril J.","family":"Van Gelderen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pam","family":"Michelow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice J.","family":"Van Den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Adam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,23]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"WHO\/ICO Information Centre on HPV and Cervical Cancer.Human Papillomavirus and Related Cancers in World. Summary Report 2010.http:\/\/www.who.int\/hpvcentre\/statistics\/en\/ [Published 2010. Updated November 15 2010. Accessed November 6 2012]"},{"key":"e_1_2_6_3_2","unstructured":"National guidelines for cervical cancer screening in South Africahttp:\/\/screening.iarc.fr\/doc\/SAcervical\u2010cancer.pdf [Published 2000. Updated January 29 2010]"},{"key":"e_1_2_6_4_2","volume-title":"Towards a National Screening Policy for Cancer of the Cervix in South Africa","author":"Fonn S.","year":"1993"},{"key":"e_1_2_6_5_2","volume-title":"Colposcopy and Programme Management: Guidelines for the NHS Cervical Screening Programme","author":"NHS Cancer Screening Programmes","year":"2004"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.11.014"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90278-B"},{"issue":"4","key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0029-7844(98)00245-2","article-title":"Natural history of cervical squamous intraepithelial lesions: a meta\u2010analysis","volume":"92","author":"Melnikow J.","year":"1998","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199304000-00018"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2042-8"},{"key":"e_1_2_6_11_2","unstructured":"Doh SA. 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