{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:22Z","timestamp":1788871882606,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T00:00:00Z","timestamp":1358640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bayer Healthcare Pharmaceuticals"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To compare clinical outcomes, including cumulative continuation rate (CCR), in the treatment of idiopathic heavy menstrual bleeding (HMB) with the levonorgestrel\u2010releasing intrauterine system (LNG\u2010IUS) and with conventional medical therapies (CMTs), including combined oral contraceptives, oral progestins, and antifibrinolytics, either alone or in combination, in the Asia\u2010Pacific region.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In a prospective observational cohort study conducted between September 2008 and December 2010, 647 women (LNG\u2010IUS, n = 483; CMTs, n = 164), aged 18\u201345 years and diagnosed with HMB, were recruited from 8 countries and followed for up to 1 year. The primary outcome was the CCR at 12 months. Secondary outcomes included bleeding pattern, an assessment of treatment efficacy by the treating physician, and safety.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The CCR at 12 months was significantly higher for LNG\u2010IUS than for CMTs (87.6% vs 56.3%\n P<\/jats:italic>\n < 0.05). Compared with CMTs, LNG\u2010IUS offered a better reduction in both subjectively assessed menstrual blood loss and the number of bleeding days, and had better efficacy for HMB, as determined by the physician's final evaluation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The present study provides information on the real\u2010life patterns of treatment of HMB in the Asia\u2010Pacific region. The efficacy of CMTs was inferior compared with LNG\u2010IUS in the clinical outcomes measured.<\/jats:p>\n \n ClinicalTrials.gov<\/jats:ext-link>\n :\n NCT00864136<\/jats:bold>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.10.028","type":"journal-article","created":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T10:16:17Z","timestamp":1358676977000},"page":"24-30","source":"Crossref","is-referenced-by-count":14,"title":["Levonorgestrel\u2010releasing intrauterine system versus conventional medical therapy for heavy menstrual bleeding in the Asia\u2010Pacific region"],"prefix":"10.1002","volume":"121","author":[{"given":"Byung S.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaheena","family":"Asif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens U.","family":"Hanisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo","family":"Inki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,20]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"National Institute for Health and Clinical Excellence.Heavy Menstrual Bleeding. NICE clinical guideline 44.http:\/\/www.nice.org.uk\/nicemedia\/pdf\/CG44NICEGuideline.pdf[Published January 2007]"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00097.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e3282f1ddbe"},{"issue":"2","key":"e_1_2_6_5_2","first-page":"21","article-title":"Managing menorrhagia. Evaluating and treating heavy menstrual bleeding","volume":"1","author":"Lopes J.E.","year":"2010","journal-title":"Adv NPs PAs"},{"key":"e_1_2_6_6_2","series-title":"Effective Health Care","volume-title":"The Management of Menorrhagia: What are Effective Ways of Treatmenting Excessive Regular Blood Loss in Primary and Secondary Care","author":"Nuffield Institute for Health","year":"1995"},{"key":"e_1_2_6_7_2","first-page":"2151","article-title":"Menorrhagia","volume":"10","author":"Duckitt K.","year":"2003","journal-title":"Clin Evid"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/11598960-000000000-00000"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.08.009"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2010.06.011"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181ec622b"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610802462605"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590903159656"},{"issue":"12","key":"e_1_2_6_14_2","first-page":"1222","article-title":"Five\u2010year follow up of women randomised to medical management or transcervical resection of the endometrium for heavy menstrual loss: clinical and quality of life outcomes","volume":"108","author":"Cooper K.G.","year":"2001","journal-title":"BJOG"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1991.tb13484.x"},{"issue":"4","key":"e_1_2_6_16_2","first-page":"210","article-title":"Efficacy of levonorgestrel intrauterine system (LNG\u2010IUS) for abnormal uterine bleeding and contraception","volume":"21","author":"Tariq N.","year":"2011","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-1937-3"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb09968.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.07.016"}],"container-title":["International Journal of Gynecology & Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729212006674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729212006674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2012.10.028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2012.10.028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2012.10.028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T19:17:31Z","timestamp":1696533451000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2012.10.028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,20]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1016\/j.ijgo.2012.10.028"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2012.10.028","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,20]]}}}