{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T17:07:59Z","timestamp":1724692079310},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T00:00:00Z","timestamp":1358380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association between post\u2010cone endocervical curettage (ECC) results, either alone or with cone margin status, and persistent\/recurrent high\u2010grade dysplasia after conization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 250 women who underwent a loop electrosurgical excision procedure with post\u2010cone ECC at Soroka Medical Center, Be'er Sheva, Israel, between January 2001 and July 2011 were reviewed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one women (12.4%) had evidence of high\u2010grade dysplasia in the ECC sample. Factors associated with positive ECC were being older than 35 years (<jats:italic>P<\/jats:italic> = 0.004) and positive margin status (<jats:italic>P<\/jats:italic> = 0.001). Twenty\u2010nine patients (11.6%) had persistent\/recurrent high\u2010grade dysplasia. Both high\u2010grade dysplasia in the ECC sample (hazard ratio, 2.31; <jats:italic>P<\/jats:italic> = 0.032) and positive cone margins (hazard ratio, 23.4; <jats:italic>P<\/jats:italic> &lt; 0.001) were associated with persistent\/recurrent disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010grade dysplasia in the ECC sample was associated with positive cone margin status. These 2 factors were both associated with persistent\/recurrent disease. Among patients with positive cone margins, a combination of margin status and ECC was superior to margin status alone for estimating the probability of persistent\/recurrent disease. For women with negative cone margins, ECC was less useful. Because ECC is valuable for assessing the risk of persistent\/recurrent high\u2010grade dysplasia in many cases, post\u2010cone ECC should be performed routinely with conization.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.10.029","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T21:31:28Z","timestamp":1358458288000},"page":"49-52","source":"Crossref","is-referenced-by-count":6,"title":["Post\u2010conization endocervical curettage for estimating the risk of persistent or recurrent high\u2010grade dysplasia"],"prefix":"10.1002","volume":"121","author":[{"given":"Ruthy","family":"Shaco\u2010Levy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Meirovitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilad","family":"Eger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Benharroch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Dreiher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(89)90551-9"},{"issue":"6","key":"e_1_2_6_3_2","first-page":"996","article-title":"The significance of positive margins in loop electrosurgical cone biopsies","volume":"84","author":"Felix J.C.","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1048-891x.2004.14215.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00399.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000206777.28541.fc"},{"issue":"2","key":"e_1_2_6_7_2","first-page":"113","article-title":"Predictive factors used to justify hysterectomy after loop conization: increasing age and severity of disease","volume":"18","author":"Kalogirou D.","year":"1997","journal-title":"Eur J Gynaecol Oncol"},{"issue":"4","key":"e_1_2_6_8_2","first-page":"189","article-title":"Clinicopathologic variables predictive of residual dysplasia after cervical conization","volume":"42","author":"Schermerhorn T.J.","year":"1997","journal-title":"J Reprod Med"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(94)00389-U"},{"issue":"2","key":"e_1_2_6_10_2","first-page":"117","article-title":"The value of endocervical curettage at time of cervical cone biopsy","volume":"85","author":"Spann C.O.","year":"1993","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349109007888"},{"issue":"10","key":"e_1_2_6_12_2","first-page":"1344","article-title":"Prevalence and risk factors for residual cervical neoplasia in subsequent hysterectomy following LEEP or conization","volume":"88","author":"Natee J.","year":"2005","journal-title":"J Med Assoc Thai"},{"issue":"2","key":"e_1_2_6_13_2","first-page":"24","article-title":"Predicting persistent\/recurrent disease in the cervix after excisional biopsy","volume":"9","author":"Ramchandani S.M.","year":"2007","journal-title":"MedGenMed"},{"issue":"4","key":"e_1_2_6_14_2","first-page":"529","article-title":"Residual disease after cone biopsy: completeness of excision and follow\u2010up cytology as predictive factors","volume":"70","author":"Buxton E.J.","year":"1987","journal-title":"Obstet Gynecol"},{"issue":"1","key":"e_1_2_6_15_2","first-page":"77","article-title":"Cervical intraepithelial neoplasia after conization: a study of 522 consecutive cervical cones","volume":"65","author":"Abdul\u2010Karim F.W.","year":"1985","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200008000-00025"}],"container-title":["International Journal of Gynecology &amp; 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