{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T05:31:54Z","timestamp":1699939914056},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bill and Melinda Gates Foundation to the Research Triangle Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To create a comprehensive model of the comparative impact of various interventions on maternal, fetal, and neonatal (MFN) mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The major conditions and sub\u2010conditions contributing to MFN mortality in low\u2010resource areas were identified, and the prevalence and case fatality rates documented. Available interventions were mapped to these conditions, and intervention coverage and efficacy were identified. Finally, a computer model developed by the Maternal and Neonatal Directed Assessment of Technology (MANDATE) initiative estimated the potential of current and new interventions to reduce mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For PPH, the sub\u2010causes, prevalence, and MFN case fatality rates were calculated. Available interventions were mapped to these sub\u2010causes. Most available interventions did not prevent or treat the overall condition of PPH, but rather sub\u2010conditions associated with hemorrhage and thus prevented only a fraction of the associated deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of current interventions address sub\u2010conditions that cause death, rather than the overall condition; thus, the potential number of lives saved is likely to be overestimated. Additionally, the location at which mother and infant receive care affects intervention effectiveness and, therefore, the potential to save lives. A comprehensive view of MFN conditions is needed to understand the impact of any potential intervention.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2012.10.030","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T19:18:52Z","timestamp":1357931932000},"page":"5-9","source":"Crossref","is-referenced-by-count":14,"title":["The MANDATE model for evaluating interventions to reduce postpartum hemorrhage"],"prefix":"10.1002","volume":"121","author":[{"given":"Elizabeth M.","family":"McClure","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris J.","family":"Rouse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily R.","family":"MacGuire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer B.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan H.","family":"Jobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beena D.","family":"Kamath\u2010Rayne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Goldenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62310-0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60549-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60518-1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2011.01275.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62235-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60678-2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016340701644876"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.07.010"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.01.009"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3181a4f737"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.02.014"},{"issue":"3","key":"e_1_2_6_14_2","first-page":"CD006431","article-title":"Uterine massage for preventing postpartum haemorrhage","author":"Hofmeyr G.J.","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.04.036"},{"issue":"7","key":"e_1_2_6_16_2","first-page":"CD007412","article-title":"Active versus expectant management for women in the third stage of labour","author":"Begley C.M.","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.10.005"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69522-6"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05835-4"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60348-0"},{"issue":"8","key":"e_1_2_6_21_2","first-page":"CD006173","article-title":"Timing of prophylactic uterotonics for the third stage of labour after vaginal birth","author":"Soltani H.","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-10-57"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2010.09.002"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-536X.2008.00299.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60474-7"}],"container-title":["International Journal of Gynecology &amp; 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