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Placentas from all of the women's pregnancies were compared in order to identify histologic similarities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both cases, multifocal hemorrhagic infarctions and abruptions were seen, indicating progressive uteroplacental ischemic damage leading to stillbirth. Thrombophilia, infection, and diabetes tests were all negative. With meticulous monitoring and normalization of thyroid function by end of first\/early second trimester in subsequent pregnancies, there were live births and no evidence of infarction on placental histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 2 reported cases raise the possibility of uteroplacental ischemia and placental abruption being mechanisms by which hypothyroidism can lead to stillbirth; they also highlight the potential of minimizing this risk via adequate levothyroxine treatment from early pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2013.05.025","type":"journal-article","created":{"date-parts":[[2013,8,31]],"date-time":"2013-08-31T21:45:32Z","timestamp":1377985532000},"page":"196-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optimal treatment of hypothyroidism associated with live birth in cases of previous recurrent placental abruption and stillbirth"],"prefix":"10.1002","volume":"123","author":[{"given":"Neil K.","family":"Vanes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorreh","family":"Charlesworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabia","family":"Imtiaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Kilby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiao Y.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00024677-200504010-00004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0041"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.60"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2566"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr024"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000152345.99421.22"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.60"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/105072502753451986"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.06030168.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016341003686081"},{"issue":"4","key":"e_1_2_6_12_2","first-page":"22","article-title":"Impact of maternal thyroid disease on the formation of relationships in the maternal\u2010placental\u2010fetal system","volume":"68","author":"Pavlova T.V.","year":"2006","journal-title":"Arkh Patol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.06.013"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.07.017"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0352"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-08-0488"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K06-062"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108329095"},{"key":"e_1_2_6_19_2","unstructured":"Royal College of Obstetricians and Gynaecologists Late Intrauterine Fetal Death and Stillbirth. 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