{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:15:05Z","timestamp":1776903305527,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":565,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ijgo.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the proportion of women with advanced maternal age (AMA) undergoing amniocentesis and assess the recommended indication of 35 years or older in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were retrospectively evaluated from 9641 patients who underwent diagnostic prenatal amniocentesis in Beijing, China, between January 2001 and December 2012. Maternal age, indication for testing, and karyotype data were collected. Patients referred for AMA were stratified in 2 ways: 35\u201337 years, 38\u201340 years, and 41 years or older; and indication of AMA alone or combined with other screening. Outcomes and safety performance were compared among the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2001 to 2012, the annual rate of amniocentesis and the proportion of AMA\u2010related indications increased (<jats:italic>P<\/jats:italic>&lt; 0.01). Overall, 82 abnormalities were detected. In the AMA group, the spontaneous abortion rate was 0.5% (22\/4748). The positive predictive value (PPV) of AMA alone was 0.5% for women aged 35\u201337 years. Only among women aged 41 years or older was the PPV of AMA alone better than that of AMA plus other indications (2.3% vs 1.5%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The PPV of 35 years or older did not offset the risk of spontaneous abortion. AMA alone should not be used as an indication for amniocentesis especially among women aged 35\u201340 years.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2013.12.004","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T04:16:13Z","timestamp":1392264973000},"page":"232-236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prenatal diagnostic testing among women referred for advanced maternal age in Beijing, 2001\u20132012"],"prefix":"10.1002","volume":"125","author":[{"given":"Jingmei","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huixia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903370327"},{"issue":"6","key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1097\/01.AOG.0000291570.63450.44","article-title":"ACOG Practice Bulletin No. 88, December 2007. Invasive prenatal testing for aneuploidy","volume":"110","author":"American College of Obstetricians and Gynecologists","year":"2007","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_4_2","unstructured":"Ministry of Health of China.Technical standards of prenatal screening and diagnosis for fetal common chromosomal abnormalities and neural tube defects.http:\/\/www.moh.gov.cn\/fzs\/s7852d\/201006\/3ee55f6ae8c64663a66bb60037793859.shtml Published 2010"},{"issue":"5","key":"e_1_2_6_5_2","article-title":"ACOG Practice Bulletin No. 27: Clinical Management Guidelines for Obstetrician\u2010Gynecologists. Prenatal diagnosis of fetal chromosomal abnormalities","volume":"97","author":"American College of Obstetricians and Gynecologists","year":"2001","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_6_2","unstructured":"DupontJ.M. CarlesE.Three year national survey of prenatal cytogenetic activity in France 1998\u20132000.http:\/\/www.biologia.uniba.it\/eca\/NEWSLETTER\/NS\u201013\/02\u2010Article.html Published January 13 2004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2764"},{"key":"e_1_2_6_8_2","unstructured":"Beijing Public Health Information Center.The status of birth or death of population in Beijing.http:\/\/www.phic.org.cn\/tonjixinxi\/weishengshujutiyao\/jiankangzhibiao\/201304\/t20130425_60101.htm Accessed 25 April 2013"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-2052-1"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1917"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043693"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182368a0e"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.021"},{"issue":"3","key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/pd.2434","article-title":"Trends in prenatal screening and diagnostic testing among women referred for advanced maternal age","volume":"30","author":"Nakata N.","year":"2010","journal-title":"Prenat Diagn"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.01.037"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.03.016"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000127008.14792.14"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2873"},{"issue":"6","key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1097\/01.AOG.0000423819.85283.f4","article-title":"Committee Opinion No. 545: Noninvasive prenatal testing for fetal aneuploidy","volume":"120","author":"American College of Obstetricians and Gynecologists Committee on Genetics","year":"2012","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_20_2","unstructured":"Royal College of Obstetricians and Gynaecologists.Amniocentesis and Chorionic Villus Sampling: Green\u2010top Guideline No. 8.http:\/\/www.rcog.org.uk\/files\/rcog\u2010corp\/GT8Amniocentesis0111.pdf Published June 2010"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4139"},{"issue":"11","key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.3760\/cma.j.issn.0366-6999.20122345","article-title":"Genetic counseling, prenatal screening and diagnosis of Down syndrome in the second trimester in women of advanced maternal age: a prospective study","volume":"126","author":"Qi Q.W.","year":"2013","journal-title":"Chin Med J (Engl)"}],"container-title":["International Journal of Gynecology &amp; 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