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Group 1 (n = 52) included patients with 500\u2013700 mL of blood loss before application of intrauterine gauze tamponade or B\u2010Lynch suture as second\u2010line therapy, while group 2 (n = 35) included patients with blood loss of more than 700 mL before application of either gauze tamponade or B\u2010Lynch suture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Management was successful in all patients in group 1. In group 2, additional management was needed in three of four patients who underwent a B\u2010lynch suture. Factors significantly associated with total blood loss were blood loss before application of second\u2010line therapy (<jats:italic>P<\/jats:italic> &lt; 0.001), fibrinogen levels (<jats:italic>P<\/jats:italic> &lt; 0.001), and time from placental separation to second\u2010line therapy (<jats:italic>P<\/jats:italic> = 0.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When blood loss is 500\u2013700 mL, compression sutures or intrauterine gauze tamponade can be used as second\u2010line treatment of postpartum hemorrhage. When blood loss is more than 700 mL, intrauterine gauze tamponade should be used.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2014.05.015","type":"journal-article","created":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T10:32:43Z","timestamp":1404556363000},"page":"180-182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Appropriate second\u2010line therapies for management of severe postpartum hemorrhage"],"prefix":"10.1002","volume":"127","author":[{"given":"Ying","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/14034940500217037"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb11471.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.06.011"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.11.025"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a114f7"},{"volume-title":"The principles and practice of obstetric medicine and surgery: in reference to the process of parturition","year":"1845","author":"Ramsbotham J.","key":"e_1_2_6_7_2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02436.x"},{"volume-title":"Prevention and management of postpartum haemorrhage","year":"2009","author":"Royal College of Obstetricians and Gynaecologists","key":"e_1_2_6_9_2"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.041"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01204.x"},{"issue":"3","key":"e_1_2_6_12_2","first-page":"502","article-title":"Uterine compression sutures: surgical management of postpartum hemorrhage","volume":"99","author":"Hayman R.G.","year":"2002","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.02.014"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.08.028"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03454.x"},{"volume-title":"Guidelines for the management of postpartum haemorrhage and retained placenta","year":"2009","author":"World Health Organization","key":"e_1_2_6_16_2"}],"container-title":["International Journal of Gynecology &amp; 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