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The frequency of couples in whom one of the partners carried balanced translocations among three chromosomes was determined, and the clinical outcomes for affected couples who subsequently achieved term pregnancies were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1415 couples with recurrent spontaneous abortion during the study period, there were two (0.1%) in which one of the partners (the woman in both cases) carried balanced translocations among three chromosomes. Both couples achieved a subsequent pregnancy that continued successfully and resulted in a phenotypically normal neonate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The frequency of balanced translocations among three chromosomes was estimated to be approximately 0.1% in a population affected by recurrent spontaneous abortion. With appropriate treatment based on careful examinations, affected couples can go on to achieve a successful pregnancy outcome.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2014.07.018","type":"journal-article","created":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T06:45:24Z","timestamp":1408171524000},"page":"36-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Complex chromosomal rearrangements in couples affected by recurrent spontaneous abortion"],"prefix":"10.1002","volume":"128","author":[{"given":"Taro","family":"Nonaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Ooki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Takakuwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,16]]},"reference":[{"issue":"2","key":"e_1_2_6_2_2","first-page":"301","article-title":"The frequency and mutation rate of balanced autosomal rearrangements in man estimated from prenatal genetic studies for advanced maternal age","volume":"35","author":"Van Dyke D.L.","year":"1983","journal-title":"Am J Hum Genet"},{"issue":"4","key":"e_1_2_6_3_2","first-page":"232","article-title":"Cytogenetic investigations in 418 couples with recurrent fetal wastage","volume":"25","author":"Osztovics M.K.","year":"1982","journal-title":"Ann Genet"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00291558"},{"issue":"1","key":"e_1_2_6_5_2","first-page":"31","article-title":"Karyotypes of 1142 couples with recurrent abortion","volume":"72","author":"Portno\u00ef M.F.","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320320434"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00284115"},{"issue":"4","key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/BF00201851","article-title":"De novo complex chromosomal rearrangement in a woman with recurrent spontaneous abortion and one healthy daughter","volume":"86","author":"Tim\u00e1r L.","year":"1991","journal-title":"Hum Genet"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg424"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)90287-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X03001326"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2006.00421.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/3.10.847"}],"container-title":["International Journal of Gynecology &amp; 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