{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:42:07Z","timestamp":1780508527520,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":175,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ijgo.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effectiveness of Foley catheter plus misoprostol for cervical ripening has not been convincingly shown in trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To summarize the evidence comparing Foley catheter plus misoprostol versus misoprostol alone for cervical ripening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Embase, Medline, and Cochrane Collaboration databases were searched with the terms \u201cFoley catheter,\u201d \u201cmisoprostol,\u201d \u201ccervical ripening,\u201d and \u201clabor induction.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Randomized controlled trials comparing the methods of cervical ripening for delivery of a viable fetus were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Study characteristics, quality, and outcomes were recorded. Random\u2010effects models were used to combine data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Eight trials were included, with 1153 patients overall. In a pooled analysis of seven high\u2010quality studies, the combination group had a decreased time to delivery (mean difference \u20132.36 hours, 95% confidence interval [CI] \u20134.07 to \u20130.66; <jats:italic>P<\/jats:italic> = 0.007). Risk of chorioamnionitis was significantly increased in the combination group (risk ratio [RR] 2.07, 95% CI 1.04\u20134.13; <jats:italic>P<\/jats:italic> = 0.04), and that of tachysystole with fetal heart rate changes was decreased (RR 0.58, 95% CI 0.38\u20130.91; <jats:italic>P<\/jats:italic> = 0.02). Frequency of cesarean did not differ (<jats:italic>P<\/jats:italic> = 0.77).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combined use of Foley catheter and misoprostol results in a reduced time to delivery, a reduced frequency tachysystole with fetal heart rate changes, and an increased incidence of chorioamnionitis.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2015.01.005","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T22:19:10Z","timestamp":1426025950000},"page":"193-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Meta\u2010analysis of Foley catheter plus misoprostol versus misoprostol alone for cervical ripening"],"prefix":"10.1002","volume":"129","author":[{"given":"Wenhang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gaudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Wu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"issue":"3","key":"e_1_2_6_2_2","first-page":"1","article-title":"Births: preliminary data for 2012","volume":"62","author":"Hamilton B.E.","year":"2013","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92406-6"},{"key":"e_1_2_6_4_2","first-page":"CD003246","article-title":"Intravenous oxytocin alone for cervical ripening and induction of labour","volume":"4","author":"Alfirevic Z.","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1967.tb03931.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02279.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.09.004"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200009000-00008"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91415-3"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00842-1"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.123821"},{"issue":"10","key":"e_1_2_6_12_2","first-page":"899","article-title":"Preinduction cervical ripening. A randomized trial of intravaginal misoprostol alone vs. a combination of transcervical Foley balloon and intravaginal misoprostol","volume":"46","author":"Rust O.A.","year":"2001","journal-title":"J Reprod Med"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12396"},{"key":"e_1_2_6_14_2","unstructured":"HigginsJ.P.T. GreenS.Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration.2011"},{"issue":"7109","key":"e_1_2_6_15_2","first-page":"629","volume":"315","author":"Egger M.","year":"1997","journal-title":"Bias in meta\u2010analysis detected by a simple, graphical test. BMJ"},{"issue":"1","key":"e_1_2_6_16_2","first-page":"12","article-title":"Comparison of intracervical foley catheter plus oral misoprostol with oral misoprostol alone for cervical ripening in primigravidas at term","volume":"119","author":"Nasir S.","year":"2012","journal-title":"BJOG"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-2094-4"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.10.323"},{"key":"e_1_2_6_19_2","first-page":"285","article-title":"Efficacy of misoprostol, misoprostol plus foley catheter, misoprostol plus foley catheter, and occitocin in second trimester termination: A retrospective study","volume":"23","author":"Atac A.","year":"2010","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.10.099"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.10.325"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.905909"},{"issue":"5","key":"e_1_2_6_23_2","first-page":"375","article-title":"Labour induction at term\u2013a randomised trial comparing Foley catheter plus titrated oral misoprostol solution, titrated oral misoprostol solution alone, and dinoprostone","volume":"93","author":"Matonhodze B.B.","year":"2003","journal-title":"S Afr Med J"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2013.786030"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31827e5dca"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091396"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.09.010"},{"key":"e_1_2_6_28_2","first-page":"CD001338","article-title":"Oral misoprostol for induction of labour","volume":"6","author":"Alfirevic Z.","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_29_2","first-page":"CD000941","article-title":"Vaginal misoprostol for cervical ripening and induction of labour","volume":"3","author":"Hofmeyr G.J.","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610500040737"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.033"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.12.039"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.02905.x"},{"issue":"2","key":"e_1_2_6_34_2","first-page":"145","article-title":"Foley catheter versus vaginal misoprostol: randomized controlled trial (PROBAAT\u2010M study) and systematic review and meta\u2010analysis of literature","volume":"31","author":"Jozwiak M.","year":"2014","journal-title":"Am J Perinatol"},{"key":"e_1_2_6_35_2","first-page":"CD001233","article-title":"Mechanical methods for induction of labour","volume":"3","author":"Jozwiak M.","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.05.005"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(96)00374-2"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08400.x"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200104000-00022"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729215001241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729215001241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2015.01.005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2015.01.005","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2015.01.005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:07:54Z","timestamp":1696381674000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2015.01.005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,10]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1016\/j.ijgo.2015.01.005"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2015.01.005","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Meta-analysis of Foley catheter plus misoprostol versus misoprostol alone for cervical ripening","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecology & Obstetrics","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.ijgo.2015.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}