{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:07:17Z","timestamp":1787062037774,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T00:00:00Z","timestamp":1426809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T00:00:00Z","timestamp":1426809600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":165,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ijgo.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy of oral misoprostol with that of oxytocin for active management of the third stage of labor (AMTSL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A double\u2010blind randomized control trial was undertaken at a center in Ilorin, Nigeria, between January and June 2013. Every other eligible patient (in the first stage of labor at term, to have a spontaneous vaginal delivery, and no\/low risk of postpartum hemorrhage [PPH]) were randomly assigned with computer\u2010generated random numbers to receive oral misoprostol (600 \u03bcg) plus placebo injection or oral placebo plus oxytocin injection (1 mL of 10 IU) in the third stage of labor. The primary outcome was amount of blood loss during delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean postpartum blood loss was 325.85 \u00b1 164.72 mL in the 100 patients given misoprostol and 303.95 \u00b1 163.33 mL in the 100 patients given oxytocin (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.391). PPH (\u2265 500 mL blood loss) was recorded in 15 (15.0%) patients given misoprostol and 14 (14.0%) given oxytocin (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.841). Shivering, pyrexia, and diarrhea were all significantly more common in the misoprostol group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The efficacy of oral misoprostol was similar to that of intramuscular oxytocin. Adverse effects associated with misoprostol were transient and self\u2010limiting. Thus, oral misoprostol is efficacious and a good alternative to oxytocin for AMTSL.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Pan African Clinical Trials Registry: PACTR201407000825227.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2015.01.008","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T06:17:55Z","timestamp":1428301075000},"page":"227-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Double\u2010blind randomized controlled trial comparing misoprostol and oxytocin for management of the third stage of labor in a Nigerian hospital"],"prefix":"10.1002","volume":"129","author":[{"given":"Abdulkarim O.","family":"Musa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir'deen A.","family":"Ijaiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakiya","family":"Saidu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiodun P.","family":"Aboyeji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiodun A.","family":"Jimoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kikelomo T.","family":"Adesina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishaq F.","family":"Abdul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,20]]},"reference":[{"issue":"1","key":"e_1_2_6_2_2","first-page":"71","article-title":"Post partum haemorrhage in a teaching hospital in Nigeria: a 5\u2010year experience","volume":"10","author":"Ajenifuja K.O.","year":"2010","journal-title":"Afr Health Sci"},{"key":"e_1_2_6_3_2","unstructured":"World Health Organization Department of Making Pregnancy Safer Reducing the Global Burden: Postpartum Hemorrhage.http:\/\/www.who.int\/maternal_child_adolescent\/documents\/newsletter\/mps_newsletter_issue4.pdf Published 2007. 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