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The betamethasone group included women with preterm labor and symptomatic contractions, cervical insufficiency, preterm premature rupture of membranes, or vaginal bleeding. Women in the control group were matched for gestational age at time of delivery and had not received betamethasone. Fetal growth changes and neonatal anthropometry were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1799 newborns in the betamethasone group and 42 240 in the control group, betamethasone was associated with significantly lower birth weight (154 g lower on average) after adjusting for confounders (e.g. hypertension, smoking, and maternal weight), sex, and gestational age at delivery (<jats:italic>P<\/jats:italic> &lt; 0.05). The higher the dose, the greater the difference in mean birth weight versus controls in births before 34<jats:sup>+ 0<\/jats:sup> weeks (\u2264 16 mg \u2212 444 g; 24 mg \u2212 523 g; &gt; 24 mg \u2212 811 g), without a detectable improvement in neonatal morbidity or mortality. There was a dose\u2010dependent decline in expected fetal weight gain as estimated by serial ultrasonography examinations 6\u20138 weeks after betamethasone administration (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Betamethasone exposure reduces fetal weight gain in a dose\u2010dependent manner without improving neonatal morbidity or mortality.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2015.01.013","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T13:00:33Z","timestamp":1428325233000},"page":"64-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Fetal and neonatal outcomes after term and preterm delivery following betamethasone administration"],"prefix":"10.1002","volume":"130","author":[{"given":"Thorsten","family":"Braun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M.","family":"Sloboda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Tutschek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Harder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.G.","family":"Challis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim W.","family":"Dudenhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Plagemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Henrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"issue":"3","key":"e_1_2_6_2_2","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","author":"Roberts D.","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08440.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.09.033"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.03.087"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.042"},{"issue":"6","key":"e_1_2_6_7_2","first-page":"CD003935","article-title":"Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes","author":"Crowther C.A.","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"e_1_2_6_8_2","first-page":"CD006764","article-title":"Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth","author":"Brownfoot F.C.","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.06.019"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.025"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.123742"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.11.007"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6673.564"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90710-1"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1999.tb00622.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70160-2"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.50.4.515"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90210-4"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318169f722"},{"key":"e_1_2_6_20_2","unstructured":"Royal College of Obstetricians and Gynaecologists Antenatal Corticosteroids to Reduce Neonatal Morbidity and Mortality: Green\u2010Top Guidline No. 7.https:\/\/www.rcog.org.uk\/globalassets\/documents\/guidelines\/gtg_7.pdf Published October 2010. 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