{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:55:04Z","timestamp":1768258504012,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":40,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81100421"],"award-info":[{"award-number":["81100421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangsu Provincial Postgraduate Innovation and Practice","award":["SJLX_0622"],"award-info":[{"award-number":["SJLX_0622"]}]},{"name":"Social Development Project in Jiangsu Province","award":["BE2010698"],"award-info":[{"award-number":["BE2010698"]}]},{"name":"Social Development Project in Jiangsu Province","award":["BE2012706"],"award-info":[{"award-number":["BE2012706"]}]},{"name":"Top Six Talent Peaks Program of Jiangsu","award":["2014-WSW-080"],"award-info":[{"award-number":["2014-WSW-080"]}]},{"name":"National Science Foundation of Yangzhou","award":["YZ2014050"],"award-info":[{"award-number":["YZ2014050"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100421"],"award-info":[{"award-number":["81100421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Provincial Postgraduate Innovation and Practice","award":["SJLX_0622"],"award-info":[{"award-number":["SJLX_0622"]}]},{"name":"Social Development Project in Jiangsu Province","award":["BE2010698"],"award-info":[{"award-number":["BE2010698"]}]},{"name":"Social Development Project in Jiangsu Province","award":["BE2012706"],"award-info":[{"award-number":["BE2012706"]}]},{"name":"Top Six Talent Peaks Program of Jiangsu","award":["2014-WSW-080"],"award-info":[{"award-number":["2014-WSW-080"]}]},{"name":"National Science Foundation of Yangzhou","award":["YZ2014050"],"award-info":[{"award-number":["YZ2014050"]}]}],"content-domain":{"domain":["ijgo.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecology & Obstetrics"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.ijgo.2015.04.046","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T14:18:52Z","timestamp":1437661132000},"page":"111-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["A systematic review and meta-analysis of metformin among patients with polycystic ovary syndrome undergoing assisted reproductive technology procedures"],"prefix":"10.1002","volume":"131","author":[{"given":"Xiaman","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reshef","family":"Tal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"issue":"(1)","key":"10.1016\/j.ijgo.2015.04.046-BIB0005|rf0005","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5694\/mja11.10553","article-title":"Prevalence of polycystic ovary syndrome in a sample of Indigenous women in Darwin, Australia","volume":"196","author":"Boyle","year":"2012","journal-title":"Med J Aust"},{"issue":"(5)","key":"10.1016\/j.ijgo.2015.04.046-BIB0010|rf0010","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.fertnstert.2011.01.007","article-title":"Prospective evaluation of basal stromal Doppler studies in women with good ovarian reserve and infertility undergoing in vitro fertilization-embryo transfer treatment: patients with polycystic ovary syndrome versus ovulatory patients","volume":"95","author":"Younis","year":"2011","journal-title":"Fertil Steril"},{"issue":"(2)","key":"10.1016\/j.ijgo.2015.04.046-BIB0015|rf0015","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Hum Reprod"},{"issue":"(1)","key":"10.1016\/j.ijgo.2015.04.046-BIB0020|rf0020","first-page":"19","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Fertil Steril"},{"issue":"(9588)","key":"10.1016\/j.ijgo.2015.04.046-BIB0025|rf0025","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet"},{"issue":"(3)","key":"10.1016\/j.ijgo.2015.04.046-BIB0030|rf0030","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/humrep\/des463","article-title":"Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp","volume":"28","author":"Stepto","year":"2013","journal-title":"Hum Reprod"},{"issue":"(2)","key":"10.1016\/j.ijgo.2015.04.046-BIB0035|rf0035","first-page":"422","article-title":"Metformin in women with PCOS, pros","volume":"48","author":"Pasquali","year":"2015","journal-title":"Endocrine"},{"issue":"(11)","key":"10.1016\/j.ijgo.2015.04.046-BIB0040|rf0040","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1093\/humrep\/des310","article-title":"Health-related quality of life in women with newly diagnosed polycystic ovary syndrome randomized between clomifene citrate plus metformin or clomifene citrate plus placebo","volume":"27","author":"Moll","year":"2012","journal-title":"Hum Reprod"},{"issue":"(7)","key":"10.1016\/j.ijgo.2015.04.046-BIB0045|rf0045","first-page":"527","article-title":"Metformin in pregnancy","volume":"85","author":"Bijok","year":"2014","journal-title":"Ginekol Pol"},{"issue":"(5)","key":"10.1016\/j.ijgo.2015.04.046-BIB0050|rf0050","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/humupd\/dmu022","article-title":"First-trimester exposure to metformin and risk of birth defects: a systematic review and meta-analysis","volume":"20","author":"Cassina","year":"2014","journal-title":"Hum Reprod Update"},{"issue":"(1)","key":"10.1016\/j.ijgo.2015.04.046-BIB0055|rf0055","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/humupd\/dms036","article-title":"Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"19","author":"Misso","year":"2013","journal-title":"Hum Reprod Update"},{"issue":"(2)","key":"10.1016\/j.ijgo.2015.04.046-BIB0060|rf0060","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijgo.2009.08.033","article-title":"Metformin versus laparoscopic ovarian drilling in clomiphene- and insulin-resistant women with polycystic ovary syndrome","volume":"108","author":"Hamed","year":"2010","journal-title":"Int J Gynecol Obstet"},{"issue":"(2)","key":"10.1016\/j.ijgo.2015.04.046-BIB0065|rf0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/01443615.2012.745839","article-title":"Effects of low-dose metformin and rosiglitazone on biochemical, clinical, metabolic and biophysical outcomes in polycystic ovary syndrome","volume":"33","author":"Mohiyiddeen","year":"2013","journal-title":"J Obstet Gynaecol"},{"issue":"(3)","key":"10.1016\/j.ijgo.2015.04.046-BIB0070|rf0070","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s10815-014-0414-x","article-title":"Metformin use in patients undergoing in vitro fertilization treatment: results of a worldwide web-based survey","volume":"32","author":"Christianson","year":"2015","journal-title":"J Assist Reprod Genet"},{"issue":"(8)","key":"10.1016\/j.ijgo.2015.04.046-BIB0075|rf0075","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1093\/humrep\/der120","article-title":"Do women with ovaries of polycystic morphology without any other features of PCOS benefit from short-term metformin co-treatment during IVF? A double-blind, placebo-controlled, randomized trial","volume":"26","author":"Swanton","year":"2011","journal-title":"Hum Reprod"},{"issue":"(6)","key":"10.1016\/j.ijgo.2015.04.046-BIB0080|rf0080","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1056\/NEJMoa063971","article-title":"Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome","volume":"356","author":"Legro","year":"2007","journal-title":"N Engl J Med"},{"issue":"(7)","key":"10.1016\/j.ijgo.2015.04.046-BIB0085|rf0085","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/01443610903147576","article-title":"Metformin in the treatment of clomiphene citrate-resistant women with polycystic ovary syndrome undergoing in vitro fertilisation treatment: a randomised controlled trial","volume":"29","author":"Qublan","year":"2009","journal-title":"J Obstet Gynaecol"},{"issue":"(6)","key":"10.1016\/j.ijgo.2015.04.046-BIB0090|rf0090","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.fertnstert.2011.09.020","article-title":"Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotropin-stimulated in vitro fertilization cycles: a randomized, controlled trial","volume":"96","author":"Palomba","year":"2011","journal-title":"Fertil Steril"},{"issue":"(8)","key":"10.1016\/j.ijgo.2015.04.046-BIB0095|rf0095","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1093\/humrep\/der154","article-title":"Use of metformin before and during assisted reproductive technology in non-obese young infertile women with polycystic ovary syndrome: a prospective, randomized, double-blind, multi-centre study","volume":"26","author":"Kj\u00f8tr\u00f8d","year":"2011","journal-title":"Hum Reprod"},{"issue":"(6)","key":"10.1016\/j.ijgo.2015.04.046-BIB0100|rf0100","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/humrep\/del025","article-title":"The use of metformin for women with PCOS undergoing IVF treatment","volume":"21","author":"Tang","year":"2006","journal-title":"Hum Reprod"},{"issue":"(7556)","key":"10.1016\/j.ijgo.2015.04.046-BIB0105|rf0105","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1136\/bmj.38867.631551.55","article-title":"Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial","volume":"332","author":"Moll","year":"2006","journal-title":"BMJ"},{"issue":"(5)","key":"10.1016\/j.ijgo.2015.04.046-BIB0110|rf0110","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.fertnstert.2011.08.020","article-title":"Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial","volume":"96","author":"Palomba","year":"2011","journal-title":"Fertil Steril"},{"issue":"(3)","key":"10.1016\/j.ijgo.2015.04.046-BIB0115|rf0115","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.fertnstert.2005.03.043","article-title":"Metformin treatment in patients with polycystic ovary syndrome undergoing in vitro fertilization: a prospective randomized trial","volume":"84","author":"Onalan","year":"2005","journal-title":"Fertil Steril"},{"issue":"(6)","key":"10.1016\/j.ijgo.2015.04.046-BIB0120|rf0120","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/humrep\/deh248","article-title":"Metformin treatment before IVF\/ICSI in women with polycystic ovary syndrome; a prospective, randomized, double blind study","volume":"19","author":"Kj\u00f8tr\u00f8d","year":"2004","journal-title":"Hum Reprod"},{"issue":"(2)","key":"10.1016\/j.ijgo.2015.04.046-BIB0125|rf0125","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/humrep\/17.2.289","article-title":"Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: a prospective randomized trial","volume":"17","author":"Yarali","year":"2002","journal-title":"Hum Reprod"},{"issue":"(1)","key":"10.1016\/j.ijgo.2015.04.046-BIB0130|rf0130","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0015-0282(01)02941-7","article-title":"Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome","volume":"77","author":"Kocak","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ijgo.2015.04.046-BIB0135|rf0135","first-page":"CD003053","article-title":"Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility","volume":"5","author":"Tang","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"(3)","key":"10.1016\/j.ijgo.2015.04.046-BIB0140|rf0140","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/1471-0528.12070","article-title":"Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials","volume":"120","author":"Palomba","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.ijgo.2015.04.046-BIB0145|rf0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-7827-12-3","article-title":"Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials","volume":"12","author":"Palomba","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"issue":"(7421)","key":"10.1016\/j.ijgo.2015.04.046-BIB0150|rf0150","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/bmj.327.7421.951","article-title":"Metformin in polycystic ovary syndrome: systematic review and meta-analysis","volume":"327","author":"Lord","year":"2003","journal-title":"BMJ"},{"issue":"(2)","key":"10.1016\/j.ijgo.2015.04.046-BIB0155|rf0155","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/09513590.2011.588749","article-title":"Metformin administration in patients with polycystic ovary syndrome who receive gonadotropins for in vitro fertilization cycles: 10-year experience in a large infertile population","volume":"28","author":"Palomba","year":"2012","journal-title":"Gynecol Endocrinol"},{"issue":"(5)","key":"10.1016\/j.ijgo.2015.04.046-BIB0160|rf0160","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1701-2163(16)34504-2","article-title":"Ovulation induction in polycystic ovary syndrome","volume":"32","author":"Vause","year":"2010","journal-title":"J Obstet Gynaecol Can"},{"issue":"(6)","key":"10.1016\/j.ijgo.2015.04.046-BIB0165|rf0165","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/humupd\/dmm026","article-title":"The role of metformin in polycystic ovary syndrome: a systematic review","volume":"13","author":"Moll","year":"2007","journal-title":"Hum Reprod Update"}],"container-title":["International Journal of Gynecology & Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729215004348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729215004348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2015.04.046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2015.04.046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1016\/j.ijgo.2015.04.046\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T20:19:08Z","timestamp":1599337148000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1016\/j.ijgo.2015.04.046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,23]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,11]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2015.04.046","archive":["Portico"],"relation":{},"ISSN":["0020-7292"],"issn-type":[{"value":"0020-7292","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7,23]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A systematic review and meta-analysis of metformin among patients with polycystic ovary syndrome undergoing assisted reproductive technology procedures","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecology & Obstetrics","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.ijgo.2015.04.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}