{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:38:43Z","timestamp":1792741123512,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,6]],"date-time":"2015-09-06T00:00:00Z","timestamp":1441497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,6]],"date-time":"2015-09-06T00:00:00Z","timestamp":1441497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,9,6]],"date-time":"2015-09-06T00:00:00Z","timestamp":1441497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ijgo.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence for the efficacy of dehydroepiandrosterone (DHEA) in improving ovarian responsiveness among poor responders, especially women with diminished ovarian reserve (DOR), remains inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of DHEA in women with DOR undergoing in vitro fertilization (IVF)\/intracytoplasmic sperm injection (ICSI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search strategy<\/jats:title>\n                    <jats:p>PubMed and Embase were searched for reports published in any language before October 31, 2014, using keywords such as \u201cDHEA,\u201d \u201cpoor ovarian response,\u201d \u201cdiminished ovarian reserve,\u201d and \u201cpremature ovarian aging.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection criteria<\/jats:title>\n                    <jats:p>Studies that explored the effects of DHEA in women with DOR undergoing IVF\/ICSI were included if they evaluated the number of oocytes retrieved and\/or the rates of clinical pregnancy, implantation, and spontaneous abortion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data collection and analysis<\/jats:title>\n                    <jats:p>Risk ratios (RRs) and standardized mean differences with 95% confidence intervals (CIs) were calculated, combined with subgroup and sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main results<\/jats:title>\n                    <jats:p>Eight studies were included. The use of DHEA increased the clinical pregnancy rate (RR 2.13; 95% CI 1.12\u20134.08). Similar results were obtained in subgroup analyses including randomized controlled trials and case\u2013control studies (RR 2.57; 95% CI 1.43\u20134.63) and self\u2010controlled studies (RR 3.95; 95% CI 1.28\u201312.19). However, the effects of DHEA on oocyte retrieval, implantation, and abortion were not significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Supplementation with DHEA has a positive effect in women undergoing IVF\/ICSI treatment for DOR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2015.06.028","type":"journal-article","created":{"date-parts":[[2015,9,6]],"date-time":"2015-09-06T00:15:25Z","timestamp":1441498525000},"page":"240-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["A meta\u2010analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection"],"prefix":"10.1002","volume":"131","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-013-0018-x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-65-6-1231"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)62164-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.05.025"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00630-5"},{"issue":"5","key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0015-0282(16)46628-8","article-title":"The endocrinology of the menstrual cycle: the interaction of folliculogenesis and neuroendocrine mechanisms","volume":"38","author":"Fritz M.A.","year":"1982","journal-title":"Fertil Steril"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0212"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml055"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/83.4.847"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.10.2129"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-007-9178-x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del254"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2011.569611"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.11.008"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-11-44"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.1.1"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.12891\/ceog16742014"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2013.819087"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq220"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-8-140"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2009.06.006"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32835175c3"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der150"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-9-67"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32832e0785"},{"issue":"3","key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.fertnstert.2005.02.049","article-title":"Increased oocyte production after treatment with dehydroepiandrosterone","volume":"84","author":"Barad D.H.","year":"2005","journal-title":"Fertil Steril"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der092"}],"container-title":["International Journal of Gynecology &amp; 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