{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:40:03Z","timestamp":1770982803076,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ijgo.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the effects of 30 \u03bcg and 20 \u03bcg ethinyl estradiol (EE) among women with polycystic ovary syndrome (PCOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a randomized study, patients with PCOS, a history of six or fewer menstrual cycles in the previous 12 months, and abnormal body hair growth were enrolled at a center in Kolkata, India, between May 1, 2012, and January 31, 2014. Participants were randomly assigned (1:1) using a computer\u2010generated randomization table to receive an oral contraceptive pill containing 3 mg drospirenone and either 30 \u03bcg EE or 20 \u03bcg EE. Patients were followed up after 6 and 12 months. The primary outcome was the absolute change in the free androgen index. Participants were masked to group assignment but investigators were not. Analyses were by intention to treat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 112 patients were enrolled. At 6 months, the free androgen index had decreased by 4.96 \u00b1 6.01 among patients receiving 30 \u03bcg (n = 55) and by 4.81 \u00b1 6.03 among those receiving 20 \u03bcg (n = 57;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.89). At 12 months, the decrease from baseline was 5.23 \u00b1 5.79 with 30 \u03bcg and 4.99 \u00b1 5.86 with 20 \u03bcg (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.82).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients with PCOS, an oral contraceptive pill containing 20 \u03bcg EE has similar effects on androgen levels to those of a pill containing 30 \u03bcg.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial Registration Number: CTRI\/2012\/04\/002571<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2015.06.065","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:16:48Z","timestamp":1446769008000},"page":"210-213","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of two contraceptive pills containing drospirenone and 20 \u03bcg or 30 \u03bcg ethinyl estradiol for polycystic ovary syndrome\n                    <sup>*<\/sup>"],"prefix":"10.1002","volume":"132","author":[{"given":"Sudhindra M.","family":"Bhattacharya","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology S. C. Das Memorial Medical and Research Center Jodhpur Park Kolkata India"},{"name":"Department of Obstetrics and Gynecology KPC Medical College and Hospital Jadavpur Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayan","family":"Jha","sequence":"additional","affiliation":[{"name":"Charleston Area Medical Center Health Education and Research Institute Charleston Area Medical Center Charleston WV USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lipika","family":"DasMukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology KPC Medical College and Hospital Jadavpur Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-992931"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2006.05.008"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1958"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500215"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(02)00436-5"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/09637480601137066"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0178"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/5.6.672"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.035"},{"issue":"1","key":"e_1_2_6_12_2","first-page":"165","article-title":"Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective controlled study in 254 affected women","volume":"84","author":"Legro R.S.","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_6_13_2","first-page":"497","article-title":"Polycystic ovary syndrome: a diagnostic challenge","volume":"14","author":"Lewis V.","year":"2003","journal-title":"Infertil Reprod Med Clin N Am"},{"key":"e_1_2_6_14_2","volume-title":"Rook's Textbook of Dermatology Vol 4","author":"Messenger A.G.","year":"2010"},{"key":"e_1_2_6_15_2","volume-title":"Clinical Gynecologic Endocrinology and Infertility","author":"Fritz M.A.","year":"2011"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1783\/1471189041261636"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346756"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2004.12.005"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(02)00537-1"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2003.11.003"},{"issue":"2","key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"353\u20139.e1","DOI":"10.1016\/j.fertnstert.2011.05.039","article-title":"Divergent effects of a combined hormonal oral contraceptive on insulin sensitivity in lean versus obese women","volume":"96","author":"Cheang K.I.","year":"2011","journal-title":"Fertil Steril"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des225"},{"issue":"4","key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jama.1993.03500040071040","article-title":"Triglyceride, high\u2010density lipoprotein and coronary heart disease. NIH Consensus Development Panel on Triglyceride, High\u2010Density Lipoprotein, and Coronary Heart Disease","volume":"269","author":"NIH Consensus conference","year":"1993","journal-title":"JAMA"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.09.014"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh207"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729215006517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729215006517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2015.06.065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2015.06.065","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2015.06.065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijgo.2015.06.065","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2015.06.065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:46:15Z","timestamp":1768423575000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2015.06.065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,6]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1016\/j.ijgo.2015.06.065"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2015.06.065","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of two contraceptive pills containing drospirenone and 20\u03bcg or 30\u03bcg ethinyl estradiol for polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecology & Obstetrics","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.ijgo.2015.06.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}