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All singleton pregnancies between 11 weeks and 13 weeks, 6 days of pregnancy were included. Patients had their body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), mean arterial pressure, uterine\u2010artery Doppler pulsatility index, and pregnancy\u2010associated plasma protein A (PAPP\u2010A) and free \u03b2\u2010human chorionic gonadotropin levels recorded. Any patients diagnosed with hypertension during follow\u2010up were assigned to the case cohort; all other patients were assigned to the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Hypertension during pregnancy was observed in 198 (9.7%) of 2042 patients that attended follow\u2010up. The mean BMI, mean arterial pressure, uterine\u2010artery Doppler pulsatility index, and the PAPP\u2010A level at study enrollment were all significantly correlated with the later development of hypertension (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001 for all variables). The combined sensitivity, specificity, positive predictive value, and negative predictive value of using the investigated parameters to predict hypertension was 76%, 80%, 31%, and 93%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patient BMI, mean arterial pressure, PAPP\u2010A, and pulsatility index were found to be effective predictors of hypertension during pregnancy. Combining these predictors may be beneficial in selecting individuals for close monitoring and early intervention during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2015.07.021","type":"journal-article","created":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T00:30:56Z","timestamp":1446856256000},"page":"159-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Early prediction of hypertension during pregnancy in a low\u2010resource setting"],"prefix":"10.1002","volume":"132","author":[{"given":"Manisha","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayashree","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Safdarjung Hospital and Vardhman Mahavir Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Singh","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karuna","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Lady Hardinge Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mujeeb U.","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of biochemistry Vallabhbhai Patel Chest Institute New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2007.06695.x"},{"issue":"5","key":"e_1_2_6_3_2","first-page":"1122","article-title":"Hypertension in pregnancy. 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