{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:52:54Z","timestamp":1779897174602,"version":"3.53.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ijgo.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the effects of pre\u2010conception thromboprophylaxis among patients with recurrent spontaneous abortion and antiphospholipid syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized placebo\u2010controlled trial enrolled patients with a history of recurrent spontaneous abortions and antiphospholipid syndrome who attended an Egyptian center between January 2011 and June 2013. Using a computer\u2010generated sequence, patients were randomly allocated to receive 41 mg enoxaparin subcutaneously plus 81 mg aspirin daily pre\u2010conception, or to receive placebo pre\u2010conception. All patients received enoxaparin and aspirin following identification of fetal heart pulsation. The primary outcomes were live\u2010birth rate and clinical\u2010pregnancy rate at 0\u20136 months, and at 6\u201312 months. Intention\u2010to\u2010treat analyses were performed. Clinicians, investigators, and data analysts were masked to the treatment assignments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study enrolled 180 patients(90 in each group). No significant difference was observed between the intervention and control groups in the live\u2010birth rate (67[74%] vs 59[66%];\n                      <jats:italic>P<\/jats:italic>\n                      = 0.25). At 0\u20136 months, the clinical\u2010pregnancy rate was higher in the intervention group (50[56%]vs 30[33%],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02). No significant difference between the intervention and control groups was observed in the clinical\u2010pregnancy rate at 6\u201312 months (32[36%] vs 35[39%],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.52).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients with recurrent spontaneous abortion and antiphospholipid syndrome, pre\u2010conception enoxaparin increased the clinical\u2010pregnancy rate at 0\u20136 months, but did not affect the clinical\u2010pregnancy rate at 6\u201312 months or the live\u2010birth rate.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>ClinicalTrials.gov: NCT01661439<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2015.09.004","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T12:45:35Z","timestamp":1449060335000},"page":"219-223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["<i>Retracted:<\/i>\n                    Randomized controlled study of pre\u2010conception thromboprophylaxis among patients with recurrent spontaneous abortion related to antiphospholipid syndrome"],"prefix":"10.1002","volume":"132","author":[{"given":"Alaa M.","family":"Ismail","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Women's Health Hospital Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali H.","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Women's Health Hospital Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdjan","family":"Saso","sequence":"additional","affiliation":[{"name":"Division of Surgery and Cancer Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad M.","family":"Abu\u2010Elhasan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Women's Health Hospital Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona M.","family":"Abu\u2010Elghar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymen N.","family":"Abdelmeged","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology EL\u2010Minia university El\u2010Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del150"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:19881002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138137"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.12.018"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1121"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0378(92)90002-L"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.09.029"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu397oa"},{"key":"e_1_2_6_12_2","unstructured":"American College of Obstetricians and Gynecologists: Anti phospholipid syndrome. 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