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Participants were evaluated 6 months and 1 year after treatment. Potential risk factors included in multivariate analyses were HIV co\u2010infection, involved margins, multicentric lesions, smoking, and use of hormonal contraception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The present study enrolled 307 participants. At 1 year, 250 (81.4%) participants were free from lesions, 30 (9.8%) had low\u2010grade squamous intraepithelial lesions, 26 (8.5%) had persistent HSILs, and 1 (0.3%) had developed invasive carcinoma. The risk of lesions persisting at 1 year after LEEP was increased by HIV infection (<jats:italic>P<\/jats:italic> = 0.003), involved margins (<jats:italic>P<\/jats:italic> = 0.05), and smoking (<jats:italic>P<\/jats:italic> = 0.02). The presence of multicentric lesions (<jats:italic>P<\/jats:italic> = 0.73) and the use of hormonal contraception (<jats:italic>P<\/jats:italic> = 0.99) did not increase the risk of lesion persistence. The risk of HSIL persistence was increased by the presence of involved margins (relative risk 3.25; 95% confidence interval 1.55\u20136.80; <jats:italic>P<\/jats:italic> = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of involved margins was the only variable that increased the risk of HSIL persistence after LEEP, increasing the risk of patients requiring further treatment.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2015.09.020","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T01:03:25Z","timestamp":1454375005000},"page":"234-237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Multivariate analysis of risk factors for the persistence of high\u2010grade squamous intraepithelial lesions following loop electrosurgical excision procedure"],"prefix":"10.1002","volume":"133","author":[{"given":"Patr\u00edcia P.","family":"dos Santos Melli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldo","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana M.","family":"Quintana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2008.11.006"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70103-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70078-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2007.01.012"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.06.012"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000167157.83098.60"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.12.003"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1258\/095646206778145703"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-0663"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.04.011"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25628"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.05.012"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/27.1.91"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/381681"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31819225cb"},{"key":"e_1_2_6_17_2","first-page":"5","article-title":"The impact of antiretroviral therapy on HPV and cervical intraepithelial neoplasia: current evidence and directions for future research","volume":"12","author":"Bratcher L.F.","year":"2010","journal-title":"Infect Agent Cancer"},{"issue":"3","key":"e_1_2_6_18_2","first-page":"233","article-title":"Predictors of recurrent dysplasia after a cervical loop electrocautery excision procedure for CIN\u20103: a study of margin, endocervical gland, and quadrant involvement","volume":"12","author":"Livasy C.A.","year":"1999","journal-title":"Mod Pathol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit181"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802012000200009"},{"issue":"11","key":"e_1_2_6_21_2","first-page":"334","article-title":"High\u2010grade intraepithelial cervical lesions: evaluation of the factors determining an unfavorable outcome after conization","volume":"33","author":"Fonseca F.V.","year":"2011","journal-title":"Rev Bras Ginecol Obstet"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2012.23.4.217"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70283-8"},{"issue":"2","key":"e_1_2_6_24_2","first-page":"24","article-title":"Predicting persistent\/recurrent disease in the cervix after excisional biopsy","volume":"9","author":"Ramchandani S.M.","year":"2007","journal-title":"MedGenMed"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28567"}],"container-title":["International Journal of Gynecology &amp; 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