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Serum PAPP\u2010A levels, pregnancy course, and outcome were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1474 women were included. An association was found between the lowest quintile of PAPP\u2010A levels (&lt; 0.4 multiples of median) for both SGA (&lt; 10th centile; 20.9% of cases in this PAPP\u2010A quintile) and preterm birth (&lt; 37 weeks; 15.8%). Women in the lowest quintile of PAPP\u2010A concentration had a significantly increased risk of SGA (&lt; 10th centile) than did those with higher concentrations (adjusted odds ratio 2.92, 95% confidence interval 2.00\u20134.27). Their risk of preterm birth (&lt; 37 weeks) was also increased (adjusted odds ratio 1.84, 95% confidence interval 1.25\u20132.72). The predictive sensitivities of the lowest quintile of PAPP\u2010A were 35.85% for SGA (&lt; 10th centile) and 27.92% for preterm birth (&lt; 37 weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low levels of PAPP\u2010A were associated with SGA and preterm births; however, poor predictive sensitivity could restrict clinical utility of this marker when used alone.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2015.09.022","type":"journal-article","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T06:16:53Z","timestamp":1453529813000},"page":"159-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Correlation of first\u2010trimester serum levels of pregnancy\u2010associated plasma protein A with small\u2010for\u2010gestational\u2010age neonates and preterm births"],"prefix":"10.1002","volume":"133","author":[{"given":"Shridevi","family":"Gundu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Gupte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmita","family":"Gupte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maitreyee","family":"Gambhir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Gambhir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,23]]},"reference":[{"volume-title":"Low Birthweight: Country, Regional and Global Estimates","year":"2004","author":"UNICEF, WHO","key":"e_1_2_6_2_2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_6_4_2","first-page":"600","article-title":"Maternal nutrition & low birth weight\u2010 what is really important?","volume":"130","author":"Muthayya S.","year":"2009","journal-title":"Indian J Med Res"},{"issue":"1","key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00006250-200701000-00054","article-title":"ACOG Practice Bulletin No. 77: screening for fetal chromosomal abnormalities","volume":"109","author":"ACOG Committee on Practice Bulletins","year":"2007","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.052"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.068"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5165"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.02.024"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4141"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5163"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3809"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199802)18:2<147::AID-PD231>3.0.CO;2-W"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32973-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60364-4"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1887021"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91342-6"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-9-48"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5206"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8430"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1898"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11618.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.407"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-013-0481-4"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.3149"}],"container-title":["International Journal of Gynecology &amp; 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