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Premenopausal patients, at least 18 years of age, who were menstruating, were randomly assigned to be treated for symptomatic uterine fibroids with either RFVTA or laparoscopic myomectomy. The outcomes included in the present per\u2010protocol analysis were patients\u2019 responses to validated questionnaires and long\u2010term safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study enrolled 51 patients; 21 and 22 patients in the RFVTA and laparoscopic myomectomy groups, respectively, completed 24 months of follow\u2010up. Improvements in the severity of symptoms from baseline were reported by participants in both the RFVTA (<jats:italic>P<\/jats:italic> &lt; 0.001) and laparoscopic myomectomy groups (<jats:italic>P<\/jats:italic> = 0.001). A significant improvement in health\u2010related quality of life was observed in the laparoscopic myomectomy group (<jats:italic>P<\/jats:italic> = 0.040); a non\u2010significant improvement was recorded in the RFVTA group (<jats:italic>P<\/jats:italic> = 0.083). A trocar\u2010site hematoma occurred in one patient in the laparoscopic myomectomy group. Further surgical interventions were recorded in three patients in the RFVTA group but these were unrelated to fibroid symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These 24\u2010month data suggest equivalence in safety and patient\u2010reported efficacy of RFVTA and laparoscopic myomectomy.<\/jats:p><jats:p><jats:bold>ClinicalTrials.gov: NCT01750008<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2015.10.008","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T14:46:06Z","timestamp":1451573166000},"page":"206-211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Interim analysis of a randomized controlled trial comparing laparoscopic radiofrequency volumetric thermal ablation of uterine fibroids with laparoscopic myomectomy"],"prefix":"10.1002","volume":"133","author":[{"given":"Bernhard","family":"Kr\u00e4mer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin\u2010Andrei","family":"Taran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorit","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith B.","family":"Isaacson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Y.","family":"Brucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.05.006"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2013.03.007"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000221"},{"issue":"1","key":"e_1_2_6_5_2","first-page":"223","article-title":"Is radiofrequency ablation equal to surgical re\u2010resection for recurrent hepatocellular carcinoma meeting the Milan criteria? 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