{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:44:40Z","timestamp":1791287080658,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ijgo.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether serum levels of 19 eicosanoids are associated with pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study was performed using data for pregnant women with pre\u2010eclampsia, normotensive pregnant women, and nonpregnant women, for all of whom serum samples had been collected at a hospital in Shanghai, China, between December 2012 and December 2013. Ultra\u2010performance liquid chromatography\u2013tandem mass spectrometry was used to measure the serum levels of 19 eicosanoids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 49 pregnant women with pre\u2010eclampsia, 26 normotensive pregnant women, and 14 nonpregnant women were included. Women with pre\u2010eclampsia had significantly higher serum levels of 11,12\u2010epoxyeicosatrienoic acid (11,12\u2010EET), the hydroxyeicosatetraenoic acids 5\u2010HETE, 8\u2010HETE, 12\u2010HETE, and 15\u2010HETE, and leukotriene B4 than did women with a normal pregnancy and nonpregnant women, both before and after the onset of pre\u2010eclampsia (<jats:italic>P<\/jats:italic> &lt; 0.01 for all comparisons). Women with severe pre\u2010eclampsia had significantly higher serum levels of 5\u2010HETE, 15\u2010HETE, and leukotriene B4 than did women with mild pre\u2010eclampsia, women with a normal pregnancy, and nonpregnant women (<jats:italic>P<\/jats:italic> &lt; 0.01 for all comparisons).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The eicosanoids 11,12\u2010EET, 5\u2010HETE, 8\u2010HETE, 12\u2010HETE, 15\u2010HETE, and leukotriene B4 might play important parts in the occurrence and development of pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2015.10.024","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T23:01:18Z","timestamp":1457737278000},"page":"291-296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association between the maternal serum levels of 19 eicosanoids and pre\u2010eclampsia"],"prefix":"10.1002","volume":"133","author":[{"given":"Anxiong","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shungao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaijun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liansheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000044"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00372"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00349.2009"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(02)00020-5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/13813450600712035"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-012-0196-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7827(03)00049-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.641"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318159cbe3"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/926968"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2007.03.001"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2011.10.006"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(02)00034-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2007.06.002"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00861.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.03.006"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200101000-00013"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr200246d"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.334"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833e86aa"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2010.10.010"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090513"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.08122FP"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70626-X"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2009.04.004"}],"container-title":["International Journal of Gynecology &amp; 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