{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:48:40Z","timestamp":1772120920332,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ijgo.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy of intramuscular hydroxyprogesterone caproate with that of vaginal progesterone for prevention of recurrent preterm birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective randomized controlled trial was conducted at a US tertiary care center between June 1, 2007, and April 30, 2010. Women with singleton pregnancies (16\u201320 weeks) and a history of spontaneous preterm birth were randomly allocated using a computer\u2010generated randomization sequence to receive either a weekly intramuscular injection of hydroxyprogesterone caproate (250 mg) or a daily vaginal progesterone suppository (100 mg). Participants, investigators, and assessors were not masked to group assignment. The primary outcome was birth before 37 weeks of pregnancy. Per\u2010protocol analyses were performed: participants who completed follow\u2010up were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analyses included 66 women given intramuscular progesterone and 79 given vaginal progesterone. Delivery before 37 weeks was recorded among 29 (43.9%) women in the intramuscular progesterone group and 30 (37.9%) in the vaginal progesterone group (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.50).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Weekly intramuscular administration of hydroxyprogesterone caproate and daily vaginal administration of a progesterone suppository exhibited similar efficacy in reducing the rate of recurrent preterm birth.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>ClinicalTrials.gov<\/jats:bold>\n                      : NCT00579553.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2016.01.010","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T07:05:17Z","timestamp":1461308717000},"page":"169-172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["A randomized controlled trial of intramuscular versus vaginal progesterone for the prevention of recurrent preterm birth"],"prefix":"10.1002","volume":"134","author":[{"given":"Andrew","family":"Elimian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Knudtson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean R.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn B.","family":"Escobedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"issue":"3","key":"e_1_2_6_2_2","first-page":"1","article-title":"Births: preliminary data for 2012","volume":"62","author":"Hamilton B.E.","year":"2013","journal-title":"Natl Vital Stat Rep"},{"issue":"1","key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1542\/peds.103.SE1.319","article-title":"Consideration of the use of health status, functional outcome, and quality\u2010of\u2010life to monitor neonatal intensive care practice","volume":"103","author":"Hack M.","year":"1999","journal-title":"Pediatrics"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198409000-00004"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035140"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.41"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb48550.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.5.1073"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00542-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12017"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.09.009"},{"issue":"8","key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.0001-6349.2005.00525.x","article-title":"Immunoglobulin levels and phagocytes in the cervical mucus plug at term of pregnancy","volume":"84","author":"Hein M.","year":"2005","journal-title":"Acta Obstet Gynecol Scand"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5159"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1980.238.3.C81"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/7.6.581"}],"container-title":["International Journal of Gynecology &amp; 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