{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T05:38:11Z","timestamp":1740116291517,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ijgo.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the utility of measuring phosphorylated insulin\u2010like growth factor\u2010binding protein 1 (phIGFBP\u20101) in cervical secretions to predict preterm birth among women with premature uterine contractions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted between September 27, 2013, and February 28, 2014, at a tertiary center in India. Participants with symptoms of preterm labor at 24\u201336 weeks underwent testing for phIGFBP\u20101 in cervical secretions. Cervical length was measured by ultrasonography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cervical swab samples tested positive for phIGFBP\u20101 among 34 (57%) of the 60 participants. Mean cervical length was 2.15 \u00b1 0.63 cm among the 46 (77%) women who delivered preterm and 2.54 \u00b1 0.47 cm among the 14 (23%) women who delivered at term. Of the 46 preterm deliveries, 29 (63%) women tested positive for phIGFBP\u20101 and 17 (37%) tested negative. Mean length of pregnancy at delivery was 32.11 \u00b1 4.09 weeks and 35.77 \u00b1 1.68 weeks among women who tested positive and negative for phIGFBP\u20101, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of phIGFBP\u20101 to predict preterm birth were 86.96%, 35.29%, 64.52%, and 66.67%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A rapid bedside test measuring phIGFBP\u20101 identified women at high risk of preterm delivery.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2016.01.019","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T23:02:48Z","timestamp":1463007768000},"page":"165-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prediction of preterm labor by a rapid bedside test detecting phosphorylated insulin\u2010like growth factor\u2010binding protein 1 in cervical 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