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Serum \u03b2\u2010hCG had been measured twice weekly from 5 to 13 weeks of pregnancy, and pregnancy was monitored by transvaginal ultrasonography to 13<jats:sup>+ 6<\/jats:sup> weeks. Optimal cutoff for peak \u03b2\u2010hCG level was determined by receiver operator characteristic curve analysis and Youden index. Women were divided into four groups on the basis of optimal peak \u03b2\u2010hCG cutoff and pregnancy outcome (pregnancy at 13 weeks or spontaneous abortion). Peak \u03b2\u2010hCG levels and length of pregnancy at this peak were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1240 patients were included. The optimal cutoff value of peak \u03b2\u2010hCG was 88 468 IU\/L, with a sensitivity, specificity, positive predictive value, and negative predictive value for successful pregnancy of 95.6%, 88.0%, 95.6%, and 89.0%, respectively. A faster rise in \u03b2\u2010hCG, higher peak \u03b2\u2010hCG, and longer pregnancy length at peak \u03b2\u2010hCG were associated with successful early pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A cutoff value of serum \u03b2\u2010hCG of 88 000 IU\/L could be used to predict early pregnancy outcomes for women with a history of RSA.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2016.03.007","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T16:24:52Z","timestamp":1464107092000},"page":"16-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Predictive value of serum \u03b2\u2010hCG for early pregnancy outcomes among women with recurrent spontaneous abortion"],"prefix":"10.1002","volume":"135","author":[{"given":"Yinglin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedan","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,2]]},"reference":[{"key":"e_1_2_6_2_2","series-title":"Progress in Obstetrics and Gynaecology","first-page":"481","volume-title":"Diagnosis and therapy of recurrent spontaneous abortion","author":"Zhang J.P.","year":"2006"},{"issue":"5","key":"e_1_2_6_3_2","first-page":"959","article-title":"Spontaneous abortion among pregnancies conceived using assisted reproductive technology in the United States","volume":"101","author":"Schieve L.A.","year":"2003","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.12.2820"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.08.018"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.02.002"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00512-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.05.071"},{"issue":"2","key":"e_1_2_6_9_2","first-page":"162","article-title":"A method of screening for ectopic pregnancy and its indications","volume":"58","author":"Kadar N.","year":"1981","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000128174.48843.12"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.01.005"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1996.tb02722.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.014"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1087104"},{"issue":"5","key":"e_1_2_6_15_2","first-page":"285","article-title":"Serum human chorionic gonadotropin level measured 17 days after oocyte retrieval can predict final clinical pregnancy outcomes in IVF\/ICSI treatment cycles","volume":"59","author":"Zhang Q.","year":"2014","journal-title":"J Reprod Med"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000196505.09016.f3"}],"container-title":["International Journal of Gynecology &amp; 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