{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:48:30Z","timestamp":1791888510124,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T00:00:00Z","timestamp":1480636800000},"content-version":"vor","delay-in-days":62,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ijgo.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the accuracy of rapid bedside tests for phosphorylated insulin\u2010like growth factor\u2010binding protein 1 (phIGFBP\u20101) and fetal fibronectin (fFN) to predict preterm delivery among women with threatened preterm labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective observational study was conducted among women with a singleton pregnancy of 28\u201336 weeks, intact membranes, and symptoms suggestive of preterm labor who attended a center in New Delhi, India, between April 1, 2011, and March 31, 2014. Rapid bedside tests were performed at presentation to measure the levels of phIGFBP\u20101 and fFN in cervicovaginal secretions. All patients were managed as per the standard hospital protocol and followed up until delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were available for 468 participants. For delivery before 37 weeks, the phIGFBP\u20101 test exhibited a sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 81.1%, 97.1%, 95.2% and 87.7%, respectively. The sensitivity, specificity, PPV, and NPV for the fFN test were 19.4%, 99.4%, 97.4%, and 63.2%, respectively. The phIGFBP\u20101 test displayed higher sensitivity and NPV than did the fFN test for delivery before 34 weeks and within 7 days of testing (<jats:italic>P<\/jats:italic>&lt; 0.05 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rapid bedside test for phIGFBP\u20101 was more reliable in the prediction of preterm delivery than was the equivalent test for fFN.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2016.03.030","type":"journal-article","created":{"date-parts":[[2016,6,19]],"date-time":"2016-06-19T12:29:49Z","timestamp":1466339389000},"page":"47-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of rapid bedside tests for phosphorylated insulin\u2010like growth factor\u2010binding protein 1 and fetal fibronectin to predict preterm birth"],"prefix":"10.1002","volume":"135","author":[{"given":"Reva","family":"Tripathi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakun","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yedla M.","family":"Mala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilanchali","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini B.","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2010.09.011"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"issue":"9606","key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg R.L.","year":"2008","journal-title":"Lancet"},{"issue":"3","key":"e_1_2_6_5_2","first-page":"446","article-title":"Prenatal plasma matrix metalloproteinase\u20109 levels to predict spontaneous preterm birth","volume":"92","author":"Tu F.F.","year":"1998","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(03)00109-X"},{"issue":"20","key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJM200005183422007","article-title":"Intrauterine infection and preterm delivery","volume":"342","author":"Goldenberg R.L.","year":"2000","journal-title":"N Engl J Med"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109053251001"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.19.6517"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90182-5"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70431-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1995.tb01976.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1998.tb03096.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80041-3"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200006000-00001"},{"issue":"6","key":"e_1_2_6_16_2","first-page":"546","article-title":"Insulin\u2010like growth factor\u2010binding protein\u20101 in cervical secretion as a predictor of preterm delivery","volume":"80","author":"Kekki M.","year":"2001","journal-title":"Acta Obstet Gynecol Scand"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.810804.x"},{"issue":"2","key":"e_1_2_6_18_2","first-page":"243","article-title":"Phosphorylated isoforms of insulin\u2010like growth factor binding protein\u20101 in the cervix as a predictor of cervical ripeness","volume":"94","author":"Nuutila M.","year":"1999","journal-title":"Obstet Gynecol"},{"issue":"6","key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"780","DOI":"10.47102\/annals-acadmedsg.kwek","article-title":"Evaluation of a bedside test for phosphorylated insulin\u2010like growth factor binding protein\u20101 in preterm labour","volume":"33","author":"Kwek K.","year":"2004","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00833.x"},{"issue":"5","key":"e_1_2_6_21_2","first-page":"368","article-title":"Value of cervical phosphorylated insulin like growth factor binding protein\u20101 in the prediction of preterm labor","volume":"49","author":"Akercan F.","year":"2004","journal-title":"J Reprod Med"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06860.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000150557.00298.47"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.390"},{"issue":"6","key":"e_1_2_6_25_2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.47102\/annals-acadmedsg.V36N6p399","article-title":"Comparison of bedside test kits for prediction of preterm delivery: phosphorylated insulin\u2010like growth factor binding protein\u20101 (plGFBP\u20101) test and fetal fibronectin test","volume":"36","author":"Ting H.S.","year":"2007","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-1839-4"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729216302077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729216302077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2016.03.030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2016.03.030","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2016.03.030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:06:05Z","timestamp":1718651165000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2016.03.030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1016\/j.ijgo.2016.03.030"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2016.03.030","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of rapid bedside tests for phosphorylated insulin-like growth factor-binding protein 1 and fetal fibronectin to predict preterm birth","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecology & Obstetrics","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.ijgo.2016.03.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}