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Patients received treatment with oral drospirenone\u2013ethinylestradiol for six treatment cycles. Dysmenorrhea, chronic pelvic pain, and dyspareunia severity were assessed using visual analog scale scores after three and six treatment cycles, and changes in perimenstrual symptoms were assessed using the menstrual distress questionnaire (MDQ) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 46 patients were recruited for the study. Dysmenorrhea, chronic pelvic pain, and dyspareunia were all significantly reduced after both three and six treatment cycles in comparison with baseline (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001 for all comparisons). After six treatment cycles, significant reductions were observed for all menstrual MDQ measures and for the premenstrual water retention and negative\u2010effect MDQ measures (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combination drospirenone\u2013ethinylestradiol was effective in the treatment of dysmenorrhea, chronic pelvic pain, dyspareunia, and somatic\/psychological symptoms in Japanese women with endometriosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T21:27:59Z","timestamp":1469827679000},"page":"135-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of low\u2010dose combined drospirenone\u2013ethinylestradiol on perimenstrual symptoms experienced by women with endometriosis"],"prefix":"10.1002","volume":"135","author":[{"given":"Yukiko","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitake","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Koshiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Kusuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Kitawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590802549858"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.08.051"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56039-7"},{"issue":"2","key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/humupd\/dmi049","article-title":"Advances in the management of endometriosis: an update for clinicians","volume":"12","author":"Crosignani P.","year":"2006","journal-title":"Hum Reprod Update"},{"key":"e_1_2_6_6_2","first-page":"CD000154","article-title":"Oral contraceptive pills for heavy menstrual bleeding","volume":"2","author":"Iyer V.","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2003.12.017"},{"key":"e_1_2_6_8_2","first-page":"CD002120","article-title":"Oral contraceptive pill for primary dysmenorrhoea","volume":"4","author":"Wong C.L.","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2003.10.030"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2011.634936"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-196811000-00006"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/09513590009167666"},{"issue":"2","key":"e_1_2_6_13_2","first-page":"79","article-title":"Effect of an oral contraceptive containing ethinyl estradiol and drospirenone on premenstrual symptomatology and health\u2010related quality of life","volume":"48","author":"Borenstein J.","year":"2003","journal-title":"J Reprod Med"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2351031283"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01962-8"},{"key":"e_1_2_6_16_2","first-page":"989","article-title":"Does the presence of coexisting diseases modulate the effectiveness of a low\u2010dose estrogen\/progestin, ethinylestradiol\/drospirenone combination tablet in dysmenorrhea? 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