{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:15:24Z","timestamp":1790248524138,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T00:00:00Z","timestamp":1480636800000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ijgo.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of prophylactic ondansetron on spinal anesthesia\u2010induced hypotension and bradycardia among patients undergoing elective cesarean deliveries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, double\u2010blind, randomized, placebo\u2010controlled trial enrolled patients aged 20\u201340 years scheduled for elective cesarean delivery under spinal anesthesia between January 1, 2015 and January 31, 2016 at Menoufia University Hospital, Egypt. Patients were randomized to receive intravenous ondansetron 4 mg in 10 mL of saline or 10 mL of saline. Participants and investigators were masked to group assignments. The primary outcomes were systolic and diastolic blood pressure, mean arterial pressure, and heart rate, measured at baseline, 10\u2010minute intervals to 60 minutes, and at 2 hours. Per\u2010protocol analyses were performed including patients who delivered under spinal anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analyses included 50 patients in each group. Decreases in systolic blood pressure were reduced among patients receiving ondansetron at all time points (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) and diastolic blood pressure did not differ between the groups (\n                      <jats:italic>P<\/jats:italic>\n                      &gt; 0.05). Among patients who received ondansetron, mean arterial pressure was higher immediately and 30 minutes after spinal anesthesia (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05), higher heart rates were recorded immediately, 20 minutes, and 50 minutes after anesthesia (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05), and the incidence of nausea (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.020) and vomiting (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.031) were lower.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prophylactic intravenous ondansetron significantly reduced hypotension and heart\u2010rate fluctuations among patients undergoing elective cesarean deliveries under spinal anesthesia.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Pan African Clinical Trials Registry<\/jats:bold>\n                      : PACTR 201601001397193\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2016.06.012","type":"journal-article","created":{"date-parts":[[2016,8,14]],"date-time":"2016-08-14T05:40:56Z","timestamp":1471153256000},"page":"205-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["EXPRESSION OF CONCERN: Randomized controlled trial comparing ondansetron and placebo for the reduction of spinal anesthesia\u2010induced hypotension during elective cesarean delivery in Egypt"],"prefix":"10.1002","volume":"135","author":[{"given":"Nabih I.","family":"El Khouly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf M.","family":"Meligy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,2]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"2024","volume-title":"Anesthesia for obstetrics","author":"Glosten B.","year":"1999"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-289X(95)82995-M"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181f2eae1"},{"issue":"4","key":"e_1_2_6_5_2","first-page":"CD002251","article-title":"Techniques for preventing hypotension during spinal anaesthesia for caesarean section","author":"Cyna A.M.","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e328337ffc6"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199206000-00006"},{"key":"e_1_2_6_8_2","first-page":"309","volume-title":"Spinal anesthesia for cesarean delivery","author":"Norris M.C.","year":"2000"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200105000-00030"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03666.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03019100"},{"key":"e_1_2_6_12_2","first-page":"1871","article-title":"A highly selective cardio renal serotonergic 5\u2010HT3\u2010mediated reflex in rats","volume":"264","author":"Veelken R.","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.65.241"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2011.08.002"},{"key":"e_1_2_6_15_2","first-page":"2203","volume-title":"Anesthesia for obstetrics","author":"Birnbach D.J.","year":"2010"},{"key":"e_1_2_6_16_2","first-page":"158061","article-title":"Effect of Ondansetron on the Occurrence of Hypotension and on Neonatal Parameters during Spinal Anesthesia for Elective Caesarean Section: A Prospective, Randomized, Controlled, Double\u2010Blind Study","volume":"2015","author":"Trabelsi W.","year":"2015","journal-title":"Anesthesiol Res Pract"},{"key":"e_1_2_6_17_2","volume-title":"SPSS Programming and Data Management, 4th Edition SPSS Programming and Data Management. 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