{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:54:11Z","timestamp":1765886051388,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ijgo.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the expression of estrogen receptor \u03b1 (ER\u03b1) and progesterone receptor (PR) in myometrium and leiomyomata tissue, and to correlate their expression with symptoms of uterine leiomyomata.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional study, intraoperative biopsy samples of leiomyomata and adjacent myometrial specimens were obtained from premenopausal women with uterine leiomyomata treated at a center in Nigeria between September 2013 and August 2014. Immunohistochemistry for ER\u03b1 and PR expression was performed on the samples. The immunoscores of both receptors were correlated with the size and symptoms of the leiomyomata.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 60 pairs of samples, leiomyomata had a higher mean expression of ER\u03b1 (H\u2010score 193.42 \u00b1 64.55 vs 153.29 \u00b1 69.13; <jats:italic>P<\/jats:italic> = 0.01) and PR (214.86 \u00b1 66.56 vs 171.53 \u00b1 63.53; <jats:italic>P<\/jats:italic> &lt; 0.001) than did myometrial tissues. The tumor diameter correlated negatively with the immunoscores of both receptors irrespective of age, parity, and body mass index, but this was only significant for PR (\u03c1 =\u20130.44; <jats:italic>P<\/jats:italic> &lt; 0.001). Downregulation of PR on leiomyomata was predicted to occur at a diameter of 11 cm. Menorrhagia, dysmenorrhea, and infertility occurred independently of steroid\u2010receptor expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Leiomyomata seem to depend on steroid hormones, but only during early tumor development. This could have implications for the selection of patients for medical management, especially with steroid\u2010receptor modulators.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2016.06.019","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T02:41:09Z","timestamp":1472179269000},"page":"314-318","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical correlates of leiomyoma estrogen and progesterone receptors among Nigerian women"],"prefix":"10.1002","volume":"135","author":[{"given":"Ibraheem O.","family":"Awowole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufemiwa N.","family":"Makinde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olusegun O.","family":"Badejoko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganiyat O.","family":"Omoniyi\u2010Esan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aramide M.","family":"Tijani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayode O.","family":"Ajenifuja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olabisi M.","family":"Loto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.99"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/94.4.435"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2008.0903"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.5787"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.09.019"},{"issue":"7","key":"e_1_2_6_7_2","first-page":"483","article-title":"Uterine leiomyomas. Racial differences in severity, symptoms and age at diagnosis","volume":"41","author":"Kjerulff K.H.","year":"1996","journal-title":"J Reprod Med"},{"issue":"6","key":"e_1_2_6_8_2","first-page":"829","article-title":"Plasma growth hormone and estradiol levels in women with uterine myomas","volume":"40","author":"Spellacy W.N.","year":"1972","journal-title":"Obstet Gynecol"},{"volume-title":"Novocastra Liquid Mouse Monoclonal Antibody Progesterone Receptor Manual","year":"2014","author":"Leica Microsystems","key":"e_1_2_6_9_2"},{"volume-title":"Novocastra Liquid Mouse Monoclonal Antibody Estrogen Receptor Manual","year":"2014","author":"Leica Mirosystems","key":"e_1_2_6_10_2"},{"issue":"1","key":"e_1_2_6_11_2","first-page":"24","article-title":"Clinical response to hormone therapy correlated with estrogen receptor analysis. Biochemical v histochemical methods","volume":"108","author":"McCarty K.S.","year":"1984","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_12_2","first-page":"93","article-title":"Uterine fibromyoma in Ilesha, Nigeria","volume":"19","author":"Ogunniyi S.O.","year":"1990","journal-title":"Nig Med Pract"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei309"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.01.142"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808188105"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2007.07.010"},{"issue":"10","key":"e_1_2_6_17_2","first-page":"1170","article-title":"Leiomyomata uteri: hormonal and molecular determinants of growth","volume":"99","author":"Blake R.E.","year":"2007","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1225"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.10.038"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2612"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000072074"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:BEBM.0000010962.35909.a1"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-07-0370"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000347017"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2014.981133"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729216303228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729216303228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2016.06.019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2016.06.019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2016.06.019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T11:24:23Z","timestamp":1740309863000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2016.06.019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,24]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1016\/j.ijgo.2016.06.019"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2016.06.019","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"type":"print","value":"0020-7292"},{"type":"electronic","value":"1879-3479"}],"subject":[],"published":{"date-parts":[[2016,8,24]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical correlates of leiomyoma estrogen and progesterone receptors among Nigerian women","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecology & Obstetrics","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.ijgo.2016.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}