{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:05:56Z","timestamp":1791011156305,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hygiene and Environmental Health"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.ijheh.2005.09.002","type":"journal-article","created":{"date-parts":[[2005,10,11]],"date-time":"2005-10-11T07:23:17Z","timestamp":1129015397000},"page":"481-488","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Chlorinated river and lake water extract caused oxidative damage, DNA migration and cytotoxicity in human cells"],"prefix":"10.1016","volume":"208","author":[{"given":"Jing","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Jiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Qing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Mersch-Sundermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijheh.2005.09.002_bib1","first-page":"503","article-title":"Duodenoesophageal reflux and the development of esophageal adenocarcinoma in rats","volume":"111","author":"Attwood","year":"1992","journal-title":"Surgery"},{"key":"10.1016\/j.ijheh.2005.09.002_bib2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0272-2712(18)30449-9","article-title":"Role of free radicals in cancer and artherosclerosis","volume":"13","author":"Bankson","year":"1993","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.ijheh.2005.09.002_bib3","first-page":"207","article-title":"Drinking water disinfection byproducts: review and approach to toxicity evaluation","volume":"107","author":"Boorman","year":"1999","journal-title":"Environ. Health. Perspect."},{"key":"10.1016\/j.ijheh.2005.09.002_bib4","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/carcin\/20.9.1801","article-title":"An esophagogastro-duodenal anastomosis model for esophageal adenocarcinogenesis in rats and enhancement by iron overload","volume":"20","author":"Chen","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ijheh.2005.09.002_bib5","series-title":"Methods in Toxicology","first-page":"33","article-title":"Membrane lipid peroxidation: celluar mechanisms and toxicological implications","author":"Ernster","year":"1994"},{"key":"10.1016\/j.ijheh.2005.09.002_bib6","first-page":"17","article-title":"Mechanisms of cell injury by activated oxygen species","volume":"10","author":"Faber","year":"1994","journal-title":"Environ. Health Perspect. Suppl."},{"key":"10.1016\/j.ijheh.2005.09.002_bib7","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/carcin\/18.11.2265","article-title":"Development of esophageal metaplasia and adenocarcinoma in a rat surgical model without the use of a carcinogen","volume":"18","author":"Goldstein","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ijheh.2005.09.002_bib8","unstructured":"Guo, J.X., Zhou, C.Z., 2002. Water quality is decreasing and Hubei Province is the first among provinces along Yantze river in a ranking list according to \u201cblow-off\u201d capacity. Avilable: http:\/\/www.china.org.cn\/chinese\/huanjing\/98031.htm"},{"issue":"1","key":"10.1016\/j.ijheh.2005.09.002_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/10408449309104073","article-title":"Free radicals as mediators of tissue injury and disease","volume":"23","author":"Kehrer","year":"1993","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ijheh.2005.09.002_bib10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0027-5107(97)00297-2","article-title":"Use of metabolically competent human hepatoma cell for the detection of mutagens and antimutagens","volume":"402","author":"Knasm\u00fcller","year":"1998","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ijheh.2005.09.002_bib11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.tox.2004.02.008","article-title":"Use of human derived liver cell lines for the detection of environmental and dietary genotoxins: current state of knowledge","volume":"198","author":"Knasm\u00fcller","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.ijheh.2005.09.002_bib12","first-page":"181","article-title":"A retrospective cohort study of risk for cancer among the population drinking water from the Donghu Lake","volume":"21","author":"Li","year":"1992","journal-title":"Acta Universitatis Medicinae Tongji"},{"key":"10.1016\/j.ijheh.2005.09.002_bib13","first-page":"8","article-title":"Study on genotoxicity and lipid peroxidation of non-volatile organic chemicals in drinking water","volume":"14","author":"Li","year":"1995","journal-title":"J. Chin. Public Health"},{"key":"10.1016\/j.ijheh.2005.09.002_bib14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0300-483X(88)90156-4","article-title":"Chlorinated drinking water is mutagenic and causes 3-methylcholanthrene type induction of hepatic monooxygenase","volume":"51","author":"Liimatainen","year":"1988","journal-title":"Toxicology"},{"key":"10.1016\/j.ijheh.2005.09.002_bib15","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1080\/15287397809529712","article-title":"Residue organic mixtures from drinking water show in vitro mutagenic and transforming activity","volume":"9","author":"Loper","year":"1978","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.ijheh.2005.09.002_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijheh.2005.09.002_bib19","first-page":"263","article-title":"A comparative study on mutagenicity of drinking water in Wuhan","volume":"7","author":"L\u00fc","year":"1999","journal-title":"Carcinogen. Teratogen. Mutagen."},{"key":"10.1016\/j.ijheh.2005.09.002_bib17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1383-5718(01)00307-2","article-title":"Studies on the in vivo and in vitro mutagenicity and the lipid peroxidation of chlorinated surface (drinking) water in rats and metabolically competent human cells","volume":"513","author":"Lu","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ijheh.2005.09.002_bib18","first-page":"326","article-title":"Genotoxicity and lipid peroxidation caused by organic extracts of chlorinated drinking water in rats and HepG2 cells","volume":"28","author":"Lu","year":"1999","journal-title":"J. Hygiene Res."},{"key":"10.1016\/j.ijheh.2005.09.002_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0027-5107(99)00010-X","article-title":"Lipid peroxidation-DNA damage by malondialdehyde","volume":"424","author":"Marnett","year":"1999","journal-title":"Mutat Res."},{"key":"10.1016\/j.ijheh.2005.09.002_bib21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tox.2004.02.009","article-title":"Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents","volume":"198","author":"Mersch-Sundermann","year":"2004","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.ijheh.2005.09.002_bib22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/0003-2697(84)90201-X","article-title":"Glutathione content of cultured cells and rodent brain regions: a specitic fluorometric assay","volume":"140","author":"Mokrasch","year":"1984","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.ijheh.2005.09.002_bib23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-3835(94)90268-2","article-title":"Enhancing effects of 3-chloro-4-(dichloromethyl)- 5-hydroxy-2(5H)-furanone (MX) on cell proliferation and lipid peroxidation in the rat gastric mucosa","volume":"85","author":"Nishikawa","year":"1994","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijheh.2005.09.002_bib24","first-page":"23","article-title":"Thoughts on the water bloom pollution in the Hanjiang river","volume":"3","author":"Sha","year":"1998","journal-title":"Environ. Herald"},{"key":"10.1016\/j.ijheh.2005.09.002_bib25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.ijheh.2005.09.002_bib26","first-page":"136","article-title":"Investigation on proliferation of Algae in Hanjiang river during low water period","volume":"19","author":"Tan","year":"2002","journal-title":"J. Environ. Health"},{"issue":"6","key":"10.1016\/j.ijheh.2005.09.002_bib27","first-page":"541","article-title":"Comparison of Mutagenicity of Nonvolatile organic compounds in water at different hydrographic periods","volume":"30","author":"Tang","year":"2001","journal-title":"Acta Univ. Med. Tongji"},{"issue":"1","key":"10.1016\/j.ijheh.2005.09.002_bib28","first-page":"24","article-title":"Standardization of measurement of lipid peroxidation in plasma with thiobarbituric acid fluorescence method","volume":"10","author":"Yu","year":"1987","journal-title":"Chin. J. Med. Lab. Sci."}],"container-title":["International Journal of Hygiene and Environmental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S143846390500115X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S143846390500115X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T17:08:03Z","timestamp":1761412083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S143846390500115X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S143846390500115X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijheh.2005.09.002","relation":{},"ISSN":["1438-4639"],"issn-type":[{"value":"1438-4639","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chlorinated river and lake water extract caused oxidative damage, DNA migration and cytotoxicity in human cells","name":"articletitle","label":"Article Title"},{"value":"International Journal of Hygiene and Environmental Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijheh.2005.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}