{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:15:22Z","timestamp":1791504922467,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"am","delay-in-days":362,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100024327","name":"Maryland Department of Health","doi-asserted-by":"publisher","award":["CH-649"],"award-info":[{"award-number":["CH-649"]}],"id":[{"id":"10.13039\/100024327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["3K07CA230182-05S1"],"award-info":[{"award-number":["3K07CA230182-05S1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["Z01-CP010119"],"award-info":[{"award-number":["Z01-CP010119"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["Z01-ES049030"],"award-info":[{"award-number":["Z01-ES049030"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hygiene and Environmental Health"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ijheh.2025.114615","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T14:58:16Z","timestamp":1751381896000},"page":"114615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Carbaryl use and incident cancer in the Agricultural Health Study: an updated analysis"],"prefix":"10.1016","volume":"268","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0102-2896","authenticated-orcid":false,"given":"Patricia A.","family":"Erickson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Andreotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard V.","family":"Remigio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7584-8856","authenticated-orcid":false,"given":"Mary H.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine G.","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6776-0018","authenticated-orcid":false,"given":"Dale P.","family":"Sandler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4661-0595","authenticated-orcid":false,"given":"Kathryn Hughes","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1043-5812","authenticated-orcid":false,"given":"Jonathan N.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Beane Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijheh.2025.114615_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.envint.2016.11.019","article-title":"Developmental neurotoxicity of succeeding generations of insecticides","volume":"99","author":"Abreu-Villa\u00e7a","year":"2017","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.ijheh.2025.114615_bib2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1047-2797(97)00120-8","article-title":"Cancer among farmers: a meta-analysis","volume":"8","author":"Acquavella","year":"1998","journal-title":"Ann. Epidemiol."},{"issue":"10","key":"10.1016\/j.ijheh.2025.114615_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109332","article-title":"Non-hodgkin lymphoma risk and insecticide, fungicide and fumigant use in the agricultural health study","volume":"9","author":"Alavanja","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ijheh.2025.114615_bib4","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1289\/ehp.96104362","article-title":"The agricultural health Study","volume":"104","author":"Alavanja","year":"1996","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.ijheh.2025.114615_bib5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/jnci\/djy201","article-title":"Response to sheppard and shaffer","volume":"111","author":"Andreotti","year":"2019","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijheh.2025.114615_bib6","series-title":"Carbaryl Chemical Review","year":"2024"},{"issue":"1","key":"10.1016\/j.ijheh.2025.114615_bib7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/00001648-200201000-00015","article-title":"Reliability of reporting on life-style and agricultural factors by a sample of participants in the Agricultural Health Study from Iowa","volume":"13","author":"Blair","year":"2002","journal-title":"Epidemiology"},{"issue":"12","key":"10.1016\/j.ijheh.2025.114615_bib8","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.3390\/ijerph8124608","article-title":"An updated algorithm for estimation of pesticide exposure intensity in the agricultural health study","volume":"8","author":"Coble","year":"2011","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"3","key":"10.1016\/j.ijheh.2025.114615_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031216","article-title":"Endocrine disruptors and prostate cancer","volume":"23","author":"Corti","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.ijheh.2025.114615_bib10","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1002\/ijc.33740","article-title":"Occupational insecticide exposure and risk of non-hodgkin lymphoma: a pooled case-control Study from the InterLymph consortium","volume":"149","author":"De Roos","year":"2021","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/j.ijheh.2025.114615_bib11","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1289\/ehp.0901518","article-title":"Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study","volume":"118","author":"Dennis","year":"2010","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.ijheh.2025.114615_bib12","first-page":"245","article-title":"A quantitative approach for estimating exposure to pesticides in the agricultural health Study","volume":"46","author":"Dosemeci","year":"2002","journal-title":"Ann. Occup. Hyg."},{"issue":"5","key":"10.1016\/j.ijheh.2025.114615_bib13","first-page":"281","article-title":"Carcinogenicity in rats of high oral doses of N-nitroso-carbaryl, a nitrosated pesticide","volume":"1","author":"Eisenbrand","year":"1976","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.ijheh.2025.114615_bib14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0015-6264(73)90139-9","article-title":"The formation of carcinogenic nitroso compounds from nitrite and some types of agricultural chemicals","volume":"11","author":"Elespuru","year":"1973","journal-title":"Food Cosmet. Toxicol."},{"key":"10.1016\/j.ijheh.2025.114615_bib15","series-title":"Article 5 of the Rotterdam Convention - Carbaryl","year":"2007"},{"issue":"4","key":"10.1016\/j.ijheh.2025.114615_bib16","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/JOM.0000000000000665","article-title":"Occupational exposure to pesticides with occupational sun exposure increases the risk for cutaneous melanoma","volume":"58","author":"Fortes","year":"2016","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.ijheh.2025.114615_bib17","series-title":"International Classification of Diseases for Oncology","author":"Fritz","year":"2013"},{"key":"10.1016\/j.ijheh.2025.114615_bib18","series-title":"Re-evaluation Decision: Carbaryl","year":"2016"},{"issue":"4","key":"10.1016\/j.ijheh.2025.114615_bib19","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/jes.2012.31","article-title":"Using multiple imputation to assign pesticide use for non-responders in the follow-up questionnaire in the Agricultural Health Study","volume":"22","author":"Heltshe","year":"2012","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"2","key":"10.1016\/j.ijheh.2025.114615_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.13031\/2013.22620","article-title":"Fungicide application practices and personal protective equipment use among orchard farmers in the agricultural health Study","volume":"13","author":"Hines","year":"2007","journal-title":"J. Agric. Saf. Health"},{"issue":"3","key":"10.1016\/j.ijheh.2025.114615_bib21","first-page":"153","article-title":"Captan exposure and evaluation of a pesticide exposure Algorithm among orchard pesticide applicators in the agricultural health Study","volume":"52","author":"Hines","year":"2008","journal-title":"Ann. Occup. Hyg."},{"issue":"5","key":"10.1016\/j.ijheh.2025.114615_bib22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/sj.jea.7500232","article-title":"Accuracy of self-reported pesticide use duration information from licensed pesticide applicators in the Agricultural Health Study","volume":"12","author":"Hoppin","year":"2002","journal-title":"J. Expo. Anal. Environ. Epidemiol."},{"key":"10.1016\/j.ijheh.2025.114615_bib23","series-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Miscellaneous Pesticides","year":"1983"},{"key":"10.1016\/j.ijheh.2025.114615_bib24","series-title":"Overall Evaluations of Carcinogenicity: an Updating of IARC Monographs Volumes 1 to 42","year":"1987"},{"key":"10.1016\/j.ijheh.2025.114615_bib25","series-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Ingested Nitrate and Nitrite, and Cyanobacterial Peptide Toxins (1017-1606 (Print) 1017-1606)","year":"2010"},{"issue":"1","key":"10.1016\/j.ijheh.2025.114615_bib26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/aje\/kws225","article-title":"Risk of total and aggressive prostate cancer and pesticide use in the Agricultural Health Study","volume":"177","author":"Koutros","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ijheh.2025.114615_bib27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.envint.2019.03.018","article-title":"Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project","volume":"127","author":"Koutros","year":"2019","journal-title":"Environ. Int."},{"issue":"9","key":"10.1016\/j.ijheh.2025.114615_bib28","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1136\/oem.2003.011858","article-title":"Agricultural pesticide use and adenocarcinomas of the stomach and oesophagus","volume":"61","author":"Lee","year":"2004","journal-title":"Occup. Environ. Med."},{"issue":"5","key":"10.1016\/j.ijheh.2025.114615_bib29","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1093\/ije\/dyz017","article-title":"Pesticide use and risk of Non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium","volume":"48","author":"Leon","year":"2019","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.ijheh.2025.114615_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/oemed-2017-104431","article-title":"Occupational pesticide exposure and subclinical hypothyroidism among male pesticide applicators","volume":"75","author":"Lerro","year":"2018","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.ijheh.2025.114615_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106187","article-title":"Pesticide exposure and incident thyroid cancer among male pesticide applicators in agricultural health study","volume":"146","author":"Lerro","year":"2021","journal-title":"Environ. Int."},{"issue":"8","key":"10.1016\/j.ijheh.2025.114615_bib32","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/ijc.22836","article-title":"Carbaryl exposure and incident cancer in the Agricultural Health Study","volume":"121","author":"Mahajan","year":"2007","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.ijheh.2025.114615_bib33","doi-asserted-by":"crossref","DOI":"10.1097\/EE9.0000000000000210","article-title":"Drinking water sources and water quality in a prospective agricultural cohort","volume":"6","author":"Manley","year":"2022","journal-title":"Environ Epidemiol"},{"issue":"2","key":"10.1016\/j.ijheh.2025.114615_bib34","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1182\/blood-2006-11-051672","article-title":"Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph)","volume":"110","author":"Morton","year":"2007","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.ijheh.2025.114615_bib35","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2","article-title":"National Cancer Institute sponsored Study of classifications of Non-Hodgkin\u2019s Lymphomas - summary and description of a working formulation for clinical usage","volume":"49","year":"1982","journal-title":"Cancer"},{"key":"10.1016\/j.ijheh.2025.114615_bib36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0027-5107(84)90076-9","article-title":"Sister-chromatid exchanges and thioguanine resistance in v79 Chinese hamster cells after treatment with the aneuploidy-inducing agent carbaryl +\/- S9 mix","volume":"125","author":"\u00d6nfelt","year":"1984","journal-title":"Mutat. Res."},{"issue":"2","key":"10.1016\/j.ijheh.2025.114615_bib37","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyy246","article-title":"Increased risk of central nervous system tumours with carbamate insecticide use in the prospective cohort AGRICAN","volume":"48","author":"Piel","year":"2019","journal-title":"Int. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.ijheh.2025.114615_bib38","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/mutage\/14.3.327","article-title":"Mitotic aberrations induced by carbaryl reflect tyrosine kinase inhibition with coincident up-regulation of serine\/threonine protein phosphatase activity: implications for coordination of karyokinesis and cytokinesis","volume":"14","author":"Renglin","year":"1999","journal-title":"Mutagenesis"},{"key":"10.1016\/j.ijheh.2025.114615_bib39","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.2741\/2312","article-title":"Chromosomal aberrations in prostate cancer","volume":"12","author":"Saramaki","year":"2007","journal-title":"Front. Biosci."},{"issue":"2","key":"10.1016\/j.ijheh.2025.114615_bib40","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/ije\/dyz263","article-title":"Occupational exposures and odds of gastric cancer: a StoP project consortium pooled analysis","volume":"49","author":"Shah","year":"2020","journal-title":"Int. J. Epidemiol."},{"issue":"6","key":"10.1016\/j.ijheh.2025.114615_bib41","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1289\/ehp.1509912","article-title":"Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis","volume":"124","author":"Smith","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ijheh.2025.114615_bib42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.etap.2015.08.014","article-title":"In vitro metabolism of methiocarb and carbaryl in rats, and its effect on their estrogenic and antiandrogenic activities","volume":"41","author":"Tange","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"6","key":"10.1016\/j.ijheh.2025.114615_bib43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/jes.2009.54","article-title":"Assessment of a pesticide exposure intensity algorithm in the agricultural health study","volume":"20","author":"Thomas","year":"2010","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.ijheh.2025.114615_bib44","series-title":"Amended Reregistration Eligibility Decision (RED) for Carbaryl (EPA-738-R-08-010)","year":"2008"},{"key":"10.1016\/j.ijheh.2025.114615_bib45","series-title":"Carbaryl: National and State Summary Use and Usage Matrix","year":"2020"},{"key":"10.1016\/j.ijheh.2025.114615_bib46","series-title":"Carbaryl: Revised Draft Human Health Risk Assessment in Support of Registration Review","year":"2021"},{"key":"10.1016\/j.ijheh.2025.114615_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.992566","article-title":"The associations between thyroid-related hormones and the risk of thyroid cancer: an overall and dose-response meta-analysis","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"7","key":"10.1016\/j.ijheh.2025.114615_bib48","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.3390\/ijerph15071557","article-title":"Drinking water nitrate and human health: an updated review","volume":"15","author":"Ward","year":"2018","journal-title":"Int. J. Environ. Res. Publ. Health"}],"container-title":["International Journal of Hygiene and Environmental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438463925000975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438463925000975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:47:28Z","timestamp":1778521648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438463925000975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":48,"alternative-id":["S1438463925000975"],"URL":"https:\/\/doi.org\/10.1016\/j.ijheh.2025.114615","relation":{},"ISSN":["1438-4639"],"issn-type":[{"value":"1438-4639","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbaryl use and incident cancer in the Agricultural Health Study: an updated analysis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Hygiene and Environmental Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijheh.2025.114615","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"114615"}}