{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:57:42Z","timestamp":1790546262277,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1718,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.ijid.2008.04.010","type":"journal-article","created":{"date-parts":[[2008,7,27]],"date-time":"2008-07-27T08:19:40Z","timestamp":1217146780000},"page":"e71-e76","source":"Crossref","is-referenced-by-count":33,"title":["Alpha-fetoprotein as a tumor marker in hepatocellular carcinoma: investigations in south Indian subjects with hepatotropic virus and aflatoxin etiologies"],"prefix":"10.1016","volume":"12","author":[{"given":"Kailapuri G.","family":"Murugavel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mathews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Jayanthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esaki Muthu","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Surendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Appasamy","family":"Vengatesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Raghuram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rajasambandam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Murali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Srinivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.R.","family":"Palaniswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Pugazhendhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadras Panchatcharam","family":"Thyagarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2008.04.010_bib1","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1038\/sj.onc.1209549","article-title":"RNA interference-mediated prevention and therapy for hepatocellular carcinoma","volume":"25","author":"Romano","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.ijid.2008.04.010_bib2","first-page":"100","article-title":"Epidemiology of digestive cancer in India\u2014III. Liver","volume":"17","author":"Dhir","year":"1998","journal-title":"Indian J Gastroenterol"},{"key":"10.1016\/j.ijid.2008.04.010_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2407-2-37","article-title":"Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease","volume":"2","author":"Shibuya","year":"2002","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijid.2008.04.010_bib4","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1053\/j.gastro.2004.09.013","article-title":"Hepatocellular carcinoma: recent trends in the United States","volume":"127","author":"El-Serag","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijid.2008.04.010_bib5","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.1038\/sj.onc.1206557","article-title":"Molecular viral oncology of hepatocellular carcinoma","volume":"22","author":"Block","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.ijid.2008.04.010_bib6","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1056\/NEJM197709222971214","article-title":"Hepatitis B virus infection in Taiwan","volume":"297","author":"Chen","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2008.04.010_bib7","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1099\/jmm.0.47151-0","article-title":"Prevalence of aflatoxin B1 in liver biopsies of proven hepatocellular carcinoma cases in India determined by an in-house immunoperoxidase test","volume":"56","author":"Murugavel","year":"2007","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.ijid.2008.04.010_bib8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/ijc.20279","article-title":"High \u03b1-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and \u03b2-catenin mutations","volume":"112","author":"Peng","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijid.2008.04.010_bib9","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/1097-0142(19891015)64:8<1700::AID-CNCR2820640824>3.0.CO;2-Z","article-title":"Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels. Analysis of 606 patients","volume":"64","author":"Nomura","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/j.ijid.2008.04.010_bib10","first-page":"327","article-title":"Clinical significance of serum alpha-fetoprotein in patients with liver cirrhosis","volume":"5","author":"Furukawa","year":"1984","journal-title":"Tumour Biol"},{"key":"10.1016\/j.ijid.2008.04.010_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0016-5085(86)90919-4","article-title":"Early detection of hepatocellular carcinoma in patients with chronic type B hepatitis. A prospective study","volume":"90","author":"Liaw","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijid.2008.04.010_bib12","first-page":"210","article-title":"Correlated clinical, histopathological, HBV and AFP studies of primary carcinoma liver","volume":"9","author":"Panchanadam","year":"1980","journal-title":"Ann Acad Med Singapore"},{"key":"10.1016\/j.ijid.2008.04.010_bib13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0168-8278(91)90946-9","article-title":"A randomised double-blind placebo-controlled trial of prednisolone therapy in HBeAg and HBV DNA positive Chinese patients with chronic active hepatitis B","volume":"12","author":"Lee","year":"1991","journal-title":"J Hepatol"},{"key":"10.1016\/j.ijid.2008.04.010_bib14","first-page":"1654","article-title":"Utility of alpha-fetoprotein (AFP) in the screening of patients with virus-related chronic liver disease: does different viral aetiology influence AFP levels in HCC? A study in 350 Western patients","volume":"47","author":"Cedrone","year":"2000","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.ijid.2008.04.010_bib15","first-page":"1747","article-title":"Usefulness of alpha-fetoprotein in the diagnosis of hepatocellular carcinoma","volume":"23","author":"Soresi","year":"2003","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ijid.2008.04.010_bib16","first-page":"17","article-title":"Species cross-reaction of alpha-fetoproteins and break-down of the tolerance to alpha-fetoprotein by immunization with heterologous alpha-fetoprotein","volume":"8","author":"Nishi","year":"1973","journal-title":"Tumour Res"},{"key":"10.1016\/j.ijid.2008.04.010_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/15287397909529750","article-title":"Aetiology of human liver cancer: controlled prospective study in liver cirrhosis","volume":"5","author":"Lehmann","year":"1979","journal-title":"J Toxicol Environ Health"},{"key":"10.1016\/j.ijid.2008.04.010_bib18","first-page":"244","article-title":"The detection of alpha 1-fetoprotein in patients with viral hepatitis","volume":"34","author":"Silver","year":"1974","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijid.2008.04.010_bib19","first-page":"1059","article-title":"Hepatocellular carcinoma in Germany. Epidemiology, aetiology, clinical aspects and prognosis in 100 consecutive patients of a university clinic","volume":"35","author":"Petry","year":"1997","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.ijid.2008.04.010_bib20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1046\/j.1365-2893.1999.00180.x","article-title":"Granulocyte-macrophage colony-stimulating factor enhances the efficacy of hepatitis B virus vaccine in previously unvaccinated haemodialysis patients","volume":"6","author":"Kapoor","year":"1999","journal-title":"J Viral Hepatol"},{"key":"10.1016\/j.ijid.2008.04.010_bib21","first-page":"103","article-title":"Alpha-fetoprotein and acute viral hepatitis type B","volume":"33","author":"Francioni","year":"1989","journal-title":"J Nucl Med Allied Sci"},{"key":"10.1016\/j.ijid.2008.04.010_bib22","doi-asserted-by":"crossref","first-page":"6409","DOI":"10.1074\/jbc.M406714200","article-title":"Des-gamma-carboxy prothrombin is a potential autologous growth factor for hepatocellular carcinoma","volume":"280","author":"Suzuki","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijid.2008.04.010_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0016-5085(03)00689-9","article-title":"Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma","volume":"125","author":"Capurro","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijid.2008.04.010_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/172460080101600204","article-title":"Clinical evaluation of lentil lectin-reactive alpha-fetoprotein-L3 in histology-proven hepatocellular carcinoma","volume":"16","author":"Khien","year":"2001","journal-title":"Int J Biol Markers"},{"key":"10.1016\/j.ijid.2008.04.010_bib25","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1046\/j.1440-1746.2001.02643.x","article-title":"Multicenter prospective analysis of newly diagnosed hepatocellular carcinoma with respect to the percentage of Lens culinaris agglutinin-reactive alpha-fetoprotein","volume":"16","author":"Oka","year":"2001","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ijid.2008.04.010_bib26","first-page":"1229","article-title":"Usefulness of Lens culinaris agglutinin A-reactive fraction of alpha-fetoprotein (AFP-L3) as a marker of distant metastasis from hepatocellular carcinoma","volume":"6","author":"Yamashiki","year":"1999","journal-title":"Oncol Rep"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S120197120801374X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S120197120801374X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T23:36:59Z","timestamp":1557704219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S120197120801374X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S120197120801374X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2008.04.010","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}