{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:13:21Z","timestamp":1789398801529,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1202,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.ijid.2009.06.002","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T06:44:48Z","timestamp":1251355488000},"page":"e328-e333","source":"Crossref","is-referenced-by-count":47,"title":["Correlation between the concentrations of tumor necrosis factor-\u03b1 and the severity of disease in patients infected with Orientia tsutsugamushi"],"prefix":"10.1016","volume":"14","author":[{"given":"Hiromichi","family":"Iwasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Mizoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ikegaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2009.06.002_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/ajh.2830360216","article-title":"Atypical lymphocytes with a multilobated nucleus from a patient with tsutsugamushi disease (scrub typhus) in Japan","volume":"36","author":"Iwasaki","year":"1991","journal-title":"Am J Hematol"},{"key":"10.1016\/j.ijid.2009.06.002_bib2","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/S0140-6736(94)92456-2","article-title":"Fulminant Rickettsia tsutsugamushi infection associated with haemophagocytic syndrome","volume":"343","author":"Iwasaki","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ijid.2009.06.002_bib3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1099\/00207713-45-3-589","article-title":"Classification of Rickettsia tsutsugamushi in a new genus, Orientia gen. nov., as Orientia tsutsugamushi comb. nov","volume":"45","author":"Tamura","year":"1995","journal-title":"Int J Syst Bacteriol"},{"key":"10.1016\/j.ijid.2009.06.002_bib4","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1128\/IAI.59.11.4134-4141.1991","article-title":"Comparative susceptibility to mouse interferons of Rickettsia tsutsugamushi strains with different virulence in mice and of Rickettsia rickettsii","volume":"59","author":"Hanson","year":"1991","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijid.2009.06.002_bib5","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1128\/IAI.69.3.1265-1272.2001","article-title":"Expression of chemokine genes in human dermal microvascular endothelial cell lines infected with Orientia tsutsugamushi","volume":"69","author":"Cho","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijid.2009.06.002_bib6","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/clinids\/18.4.624","article-title":"Life-threatening scrub typhus in a traveler returning from Thailand","volume":"18","author":"Watt","year":"1994","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2009.06.002_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1574-6968.1999.tb08791.x","article-title":"Phylogenetic analysis of Orientia tsutsugamushi strains based on the sequence homologies of 56-kDa type specific antigen genes","volume":"15","author":"Enatsu","year":"1999","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.ijid.2009.06.002_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.actatropica.2007.07.013","article-title":"Development of a real-time PCR assay for the diagnosis of scrub typhus cases in India and evidence of the prevalence of new genotype of O. tsutsugamushi","volume":"104","author":"Bakshi","year":"2007","journal-title":"Acta Trop"},{"key":"10.1016\/j.ijid.2009.06.002_bib9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1469-0691.2007.01889.x","article-title":"Detection of new genotypes of Orientia tsutsugamushi infecting humans in Thailand","volume":"14","author":"Fournier","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijid.2009.06.002_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1348-0421.2008.00024.x","article-title":"Epidemiological characteristics of tsutsugamushi disease in Oita Prefecture, Japan: yearly and monthly occurrences of its infections and serotypes of its causative agent, Orientia tsutsugamushi, during 1984\u20132005","volume":"52","author":"Ogawa","year":"2008","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.ijid.2009.06.002_bib11","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1378\/chest.101.6.1481","article-title":"The ACCP-SCCM consensus conference on sepsis and organ failure","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.ijid.2009.06.002_bib12","first-page":"85","article-title":"Immunodepression in sepsis and SIRS assessed by ex vivo cytokine production is not a generalized phenomenon: a review","volume":"7","author":"Cavaillon","year":"2001","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.ijid.2009.06.002_bib13","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1128\/JCM.35.12.3320-3322.1997","article-title":"Increased levels of macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha in sera of patients with Orientia tsutsugamushi infection","volume":"35","author":"Iwasaki","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2009.06.002_bib14","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1067\/mlc.2002.129308","article-title":"Doxycycline induces apoptosis by way of caspase-3 activation with inhibition of matrix metalloproteinase in human T-lymphoblastic leukemia CCRF-CEM cells","volume":"140","author":"Iwasaki","year":"2002","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.ijid.2009.06.002_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1189\/jlb.0804477","article-title":"Minocycline attenuates T cell and microglia activity to impair cytokine production in T cell\u2013microglia interaction","volume":"78","author":"Giuliani","year":"2005","journal-title":"J Leukocyte Biol"},{"key":"10.1016\/j.ijid.2009.06.002_bib16","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.bcp.2007.09.012","article-title":"A novel formulation, hyperresponsiveness and remodeling by matrix metalloproteinases and cytokines modulation in a mouse model of asthma","volume":"75","author":"Gueders","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ijid.2009.06.002_bib17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tox.2007.11.003","article-title":"Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity","volume":"244","author":"Ahuja","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.ijid.2009.06.002_bib18","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1128\/JCM.15.6.1128-1132.1982","article-title":"Serodiagnosis of tsutsugamushi fever (scrub typhus) by the indirect immunoperoxidase technique","volume":"15","author":"Yamamoto","year":"1982","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2009.06.002_bib19","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(96)06413-6","article-title":"Genetic influence on cytokine production and fatal meningococcal disease","volume":"349","author":"Westendorp","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.ijid.2009.06.002_bib20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1440-1711.1999.00796.x","article-title":"Western blot analysis of bile or intestinal fluid from patients with septic shock or systemic inflammatory response syndrome, using antibodies to TNF-alpha, IL-1 alpha and IL-1 beta","volume":"77","author":"Belov","year":"1999","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.ijid.2009.06.002_bib21","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1348-0421.2005.tb03761.x","article-title":"Chemokine and cytokine production in susceptible C3H\/HeN mice and resistant BALB\/c mice during Orientia tsutsugamushi infection","volume":"49","author":"Yun","year":"2005","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.ijid.2009.06.002_bib22","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1128\/IAI.60.10.4003-4008.1992","article-title":"Tumor necrosis factor and interleukin-6 in Candida albicans infection in normal and granulocytopenic mice","volume":"60","author":"Steinshamn","year":"1992","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijid.2009.06.002_bib23","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1189\/jlb.0506298","article-title":"Pivotal advance: a-galactosylceramide induces protection against lipopolysaccharide-induced shock","volume":"81","author":"Sireci","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ijid.2009.06.002_bib24","first-page":"574","article-title":"Monoclonal antibody to tumor necrosis factor-alpha prevents lethal endotoxin sepsis in adult rhesus monkeys","volume":"120","author":"Fiedler","year":"1992","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.ijid.2009.06.002_bib25","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1128\/IAI.61.12.5198-5204.1993","article-title":"Parasite virulence factors during falciparum malaria: rosetting, cytoadherence, and modulation of cytoadherence by cytokines","volume":"61","author":"Ringwald","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijid.2009.06.002_bib26","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/SHK.0b013e31815071e9","article-title":"Critical role for small and large conductance calcium-dependent potassium channels in endotoxemia and TNF toxicity","volume":"29","author":"Cauwels","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.ijid.2009.06.002_bib27","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/S0140-6736(05)60606-X","article-title":"Anti-inflammatory cytokine profile and mortality in febrile patients","volume":"351","author":"van Dissel","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ijid.2009.06.002_bib28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10-deficient mice develop chronic enterocolitis","volume":"75","author":"Kuhn","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ijid.2009.06.002_bib29","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1128\/IAI.70.8.4441-4446.2002","article-title":"Interleukin-10 controls the onset of irreversible septic shock","volume":"70","author":"Latifi","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijid.2009.06.002_bib30","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.4049\/jimmunol.168.10.4837","article-title":"Evidence for a dual mechanism for IL-10 suppression of TNF-\u03b1 production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-\u03baB in primary human macrophages","volume":"168","author":"Denys","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.ijid.2009.06.002_bib31","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1128\/IAI.01249-06","article-title":"Respiratory tract infection with Mycoplasma pneumoniae in interleukin-12 knockout mice results in improved bacterial clearance and reduced pulmonary inflammation","volume":"75","author":"Salvatore","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijid.2009.06.002_bib32","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1073\/pnas.88.10.4143","article-title":"Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor","volume":"88","author":"Gubler","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijid.2009.06.002_bib33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1084\/jem.170.3.827","article-title":"Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes","volume":"170","author":"Kobayashi","year":"1989","journal-title":"J Exp Med"},{"key":"10.1016\/j.ijid.2009.06.002_bib34","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.1073\/pnas.87.17.6808","article-title":"Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells","volume":"87","author":"Stern","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijid.2009.06.002_bib35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4269\/ajtmh.1995.52.325","article-title":"Eradication of Rickettsia tsutsugamushi from patients\u2019 blood by chemotherapy, as assessed by the polymerase chain reaction","volume":"52","author":"Murai","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ijid.2009.06.002_bib36","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1128\/JCM.00997-08","article-title":"Orientia tsutsugamushi bacteremia and cytokine levels in Vietnamese scrub typhus patients","volume":"47","author":"Kramme","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2009.06.002_bib37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jinf.2007.09.009","article-title":"Kinetics of inflammatory cytokines in patients with scrub typhus receiving doxycycline treatment","volume":"56","author":"Chung","year":"2008","journal-title":"J Infection"},{"key":"10.1016\/j.ijid.2009.06.002_bib38","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s10753-009-9111-9","article-title":"Tetracyclines and chemically modified tetracycline-3 (CMT-3) modulate cytokine secretion by lipopolysaccharide-stimulated whole blood","volume":"32","author":"Cazalis","year":"2009","journal-title":"Inflammation"},{"key":"10.1016\/j.ijid.2009.06.002_bib39","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1128\/JCM.39.6.2341-2343.2001","article-title":"Fulminant Japanese spotted fever associated with hypercytokinemia","volume":"39","author":"Iwasaki","year":"2001","journal-title":"J Clin Microbiol"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971209002410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971209002410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T23:37:34Z","timestamp":1633822654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971209002410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S1201971209002410"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2009.06.002","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}