{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:29:22Z","timestamp":1790749762824,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1086,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.ijid.2009.12.002","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T09:05:31Z","timestamp":1271667931000},"page":"e739-e743","source":"Crossref","is-referenced-by-count":56,"title":["Enterovirus 71 vaccine: close but still far"],"prefix":"10.1016","volume":"14","author":[{"given":"Dingmei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2009.12.002_bib1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1136\/adc.55.8.583","article-title":"Outbreaks of hand, foot, and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system","volume":"55","author":"Ishimaru","year":"1980","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ijid.2009.12.002_bib2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/infdis\/129.3.304","article-title":"An apparently new enterovirus isolated from patients with disease of the central nervous system","volume":"129","author":"Schmidt","year":"1974","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2009.12.002_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0140-6736(74)91684-5","article-title":"Letter: New enterovirus type associated with epidemic of aseptic meningitis and-or hand, foot, and mouth disease","volume":"2","author":"Blomberg","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.ijid.2009.12.002_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.7883\/yoken1952.34.191","article-title":"A large-scale epidemic of hand, foot and mouth disease associated with enterovirus 71 infection in Japan in 1978","volume":"34","author":"Tagaya","year":"1981","journal-title":"Jpn J Med Sci Biol"},{"key":"10.1016\/j.ijid.2009.12.002_bib5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF01314873","article-title":"Virological diagnosis of enterovirus type 71 infections: experiences gained during an epidemic of acute CNS diseases in Hungary in 1978","volume":"71","author":"Nagy","year":"1982","journal-title":"Arch Virol"},{"key":"10.1016\/j.ijid.2009.12.002_bib6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/00006454-198807000-00007","article-title":"Outbreak of enterovirus 71 infection in Victoria, Australia, with a high incidence of neurologic involvement","volume":"7","author":"Gilbert","year":"1988","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.ijid.2009.12.002_bib7","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00006454-198702000-00013","article-title":"Monoplegia caused by Enterovirus 71: an outbreak in Hong Kong","volume":"6","author":"Samuda","year":"1987","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.ijid.2009.12.002_bib8","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group","volume":"341","author":"Ho","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2009.12.002_bib9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1348-0421.2002.tb02743.x","article-title":"Outbreak of central nervous system disease associated with hand, foot, and mouth disease in Japan during the summer of 2000: detection and molecular epidemiology of enterovirus 71","volume":"46","author":"Fujimoto","year":"2002","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.ijid.2009.12.002_bib10","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1128\/JCM.40.8.2823-2827.2002","article-title":"Direct detection of enterovirus 71 (EV71) in clinical specimens from a hand, foot, and mouth disease outbreak in Singapore by reverse transcription-PCR with universal enterovirus and EV71-specific primers","volume":"40","author":"Singh","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2009.12.002_bib11","unstructured":"World Health Organization. Outbreak news. Enterovirus, China. Wkly Epidemiol Rec 2008; 83:169\u201370."},{"key":"10.1016\/j.ijid.2009.12.002_bib12","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1128\/JCM.00563-09","article-title":"Enterovirus 71 outbreak in the People's Republic of China in 2008","volume":"47","author":"Yang","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2009.12.002_bib13","unstructured":"Ministry of health of the people's republic of China, Reports of National Notifiable Communicable Diseases. <http:\/\/www.moh.gov.cn\/publicfiles\/\/business\/htmlfiles\/zwgkzt\/pyq\/list.htm>."},{"key":"10.1016\/j.ijid.2009.12.002_bib14","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1542\/peds.2006-3331","article-title":"Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998\u20132005","volume":"120","author":"Chen","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijid.2009.12.002_bib15","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1073\/pnas.84.12.4002","article-title":"Poliovirus polypeptide precursors: expression in vitro and processing by exogenous 3C and 2A proteinases","volume":"84","author":"Nicklin","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijid.2009.12.002_bib16","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1023\/A:1024071514438","article-title":"Formation of enterovirus-like particle aggregates by recombinant baculoviruses co-expressing P1 and 3CD in insect cells","volume":"25","author":"Hu","year":"2003","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.ijid.2009.12.002_bib17","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/S0264-410X(03)00070-7","article-title":"The efficacy, effectiveness and cost-effectiveness of inactivated influenza virus vaccines","volume":"21","author":"Nichol","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2009.12.002_bib18","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1016\/S0264-410X(01)00195-5","article-title":"A randomised comparison of two inactivated hepatitis A vaccines, Avaxim and Vaqta, given as a booster to subjects primed with Avaxim","volume":"19","author":"Clarke","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2009.12.002_bib19","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1542\/peds.109.6.e88","article-title":"Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease\/herpangina in children during an epidemic in Taiwan","volume":"109","author":"Chang","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijid.2009.12.002_bib20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF02253368","article-title":"Neutralizing antibody provided protection against enterovirus type 71 lethal challenge in neonatal mice","volume":"7","author":"Yu","year":"2000","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.ijid.2009.12.002_bib21","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0264-410X(01)00385-1","article-title":"Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus","volume":"20","author":"Wu","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2009.12.002_bib22","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/S0264-410X(02)00182-2","article-title":"Characterization of a Vero cell-adapted virulent strain of enterovirus 71 suitable for use as a vaccine candidate","volume":"20","author":"Lin","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2009.12.002_bib23","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1016\/j.vaccine.2004.05.037","article-title":"Optimization of microcarrier cell culture process for the inactivated enterovirus type 71 vaccine development","volume":"22","author":"Wu","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2009.12.002_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.vaccine.2006.06.083","article-title":"High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture","volume":"25","author":"Liu","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2009.12.002_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1586\/14760584.8.1.35","article-title":"Oral polio vaccines and their role in polio eradication in India","volume":"8","author":"Paul","year":"2009","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.ijid.2009.12.002_bib26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1586\/14760584.8.1.5","article-title":"Role of injectable and oral polio vaccines in polio eradication","volume":"8","author":"John","year":"2009","journal-title":"Expert Rev Vaccines"},{"issue":"Pt 5","key":"10.1016\/j.ijid.2009.12.002_bib27","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1099\/vir.0.80784-0","article-title":"Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys","volume":"86","author":"Arita","year":"2005","journal-title":"J Gen Virol"},{"key":"10.1016\/j.ijid.2009.12.002_bib28","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1128\/JVI.01798-07","article-title":"Cooperative effect of the attenuation determinants derived from poliovirus Sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD\/SCID mouse infection model","volume":"82","author":"Arita","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.ijid.2009.12.002_bib29","doi-asserted-by":"crossref","first-page":"9386","DOI":"10.1128\/JVI.02856-06","article-title":"An attenuated strain of enterovirus 71 belonging to genotype A showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys","volume":"81","author":"Arita","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.ijid.2009.12.002_bib30","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1146\/annurev.micro.58.030603.123625","article-title":"Vaccine-derived polioviruses and the endgame strategy for global polio eradication","volume":"59","author":"Kew","year":"2005","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.ijid.2009.12.002_bib31","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00431-008-0674-5","article-title":"Novel BTK mutation presenting with vaccine-associated paralytic poliomyelitis","volume":"167","author":"Mamishi","year":"2008","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.ijid.2009.12.002_bib32","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1046\/j.1440-1754.2000.00514.x","article-title":"A case of vaccine-associated paralytic poliomyelitis","volume":"36","author":"Edwards","year":"2000","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.ijid.2009.12.002_bib33","unstructured":"The Department of Vaccines and Biologicals. Adverse events following poliomyelitis vaccine. In: Clements DC, editor. Supplementary information on vaccine safety. Geneva: World Health Organization; 2000, p.78."},{"key":"10.1016\/j.ijid.2009.12.002_bib34","first-page":"205","article-title":"Enterovirus 71: the virus, its infections and outbreaks","volume":"33","author":"Ho","year":"2000","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.ijid.2009.12.002_bib35","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1128\/CMR.5.3.328","article-title":"Oral immunization using live attenuated Salmonella spp. as carriers of foreign antigens","volume":"5","author":"Cardenas","year":"1992","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijid.2009.12.002_bib36","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1586\/14760584.7.6.729","article-title":"Oral vaccine delivery: can it protect against non-mucosal pathogens?","volume":"7","author":"Wang","year":"2008","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.ijid.2009.12.002_bib37","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1016\/j.vaccine.2005.12.047","article-title":"Oral immunization of mice using transgenic tomato fruit expressing VP1 protein from enterovirus 71","volume":"24","author":"Chen","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2009.12.002_bib38","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1016\/j.vaccine.2008.03.041","article-title":"Expression of VP1 protein in the milk of transgenic mice: a potential oral vaccine protects against enterovirus 71 infection","volume":"26","author":"Chen","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2009.12.002_bib39","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.micinf.2006.01.021","article-title":"Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71","volume":"8","author":"Chiu","year":"2006","journal-title":"Microbes Infect"},{"key":"10.1016\/j.ijid.2009.12.002_bib40","first-page":"17","article-title":"Efficient intranasal immunization of newborn mice with recombinant adenovirus expressing rotavirus protein VP4 against oral rotavirus infection","volume":"49","author":"Liu","year":"2005","journal-title":"Acta Virol"},{"key":"10.1016\/j.ijid.2009.12.002_bib41","doi-asserted-by":"crossref","first-page":"7664","DOI":"10.1016\/j.vaccine.2007.08.034","article-title":"Oral vaccination with liposome-encapsulated recombinant fusion peptide of urease B epitope and cholera toxin B subunit affords prophylactic and therapeutic effects against H. pylori infection in BALB\/c mice","volume":"25","author":"Zhao","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2009.12.002_bib42","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijpharm.2007.07.035","article-title":"In vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein delivery","volume":"349","author":"Chen","year":"2008","journal-title":"Int J Pharm"},{"key":"10.1016\/j.ijid.2009.12.002_bib43","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1146\/annurev.immunol.18.1.927","article-title":"DNA vaccines: immunology, application, and optimization","volume":"18","author":"Gurunathan","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ijid.2009.12.002_bib44","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1479-0556-5-6","article-title":"DNA vaccine constructs against enterovirus 71 elicit immune response in mice","volume":"5","author":"Tung","year":"2007","journal-title":"Genet Vaccines Ther"},{"key":"10.1016\/j.ijid.2009.12.002_bib45","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0168-1656(03)00029-4","article-title":"Intradermal immunization with novel plasmid DNA-coated nanoparticles via a needle-free injection device","volume":"102","author":"Cui","year":"2003","journal-title":"J Biotechnol"},{"key":"10.1016\/j.ijid.2009.12.002_bib46","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1016\/j.vaccine.2007.01.120","article-title":"Chemical adjuvants for plasmid DNA vaccines","volume":"25","author":"Greenland","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2009.12.002_bib47","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1479-0556-1-2","article-title":"DNA vaccines: improving expression of antigens","volume":"1","author":"Garmory","year":"2003","journal-title":"Genet Vaccines Ther"},{"key":"10.1016\/j.ijid.2009.12.002_bib48","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/vim.2007.0089","article-title":"Identification of human CD4 T-cell epitopes on the VP1 capsid protein of enterovirus 71","volume":"21","author":"Foo","year":"2008","journal-title":"Viral Immunol"},{"key":"10.1016\/j.ijid.2009.12.002_bib49","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.virusres.2006.12.005","article-title":"Identification of neutralizing linear epitopes from the VP1 capsid protein of Enterovirus 71 using synthetic peptides","volume":"125","author":"Foo","year":"2007","journal-title":"Virus Res"},{"key":"10.1016\/j.ijid.2009.12.002_bib50","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.micinf.2007.06.002","article-title":"Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide","volume":"9","author":"Foo","year":"2007","journal-title":"Microbes Infect"},{"key":"10.1016\/j.ijid.2009.12.002_bib51","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.bbrc.2009.09.103","article-title":"Generation of neutralizing monoclonal antibodies against Enterovirus 71 using synthetic peptides","volume":"390","author":"Li","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ijid.2009.12.002_bib52","doi-asserted-by":"crossref","first-page":"10527","DOI":"10.1073\/pnas.89.21.10527","article-title":"Chimeric gag-V3 virus-like particles of human immunodeficiency virus induce virus-neutralizing antibodies","volume":"89","author":"Luo","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijid.2009.12.002_bib53","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.bbrc.2004.04.111","article-title":"Assembly of human severe acute respiratory syndrome coronavirus-like particles","volume":"318","author":"Ho","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ijid.2009.12.002_bib54","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3748\/wjg.v12.i6.921","article-title":"Expression, purification and characterization of enterovirus-71 virus-like particles","volume":"12","author":"Chung","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ijid.2009.12.002_bib55","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.vaccine.2008.01.058","article-title":"Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge","volume":"26","author":"Chung","year":"2008","journal-title":"Vaccine"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971210023131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971210023131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T19:21:57Z","timestamp":1544556117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971210023131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S1201971210023131"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2009.12.002","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}