{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:42:00Z","timestamp":1791852120269,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":478,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.ijid.2012.01.006","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T02:33:04Z","timestamp":1331001184000},"page":"e358-e363","source":"Crossref","is-referenced-by-count":11,"title":["High frequency variations of Helicobacter pylori isolates in individual hosts in a Chinese population"],"prefix":"10.1016","volume":"16","author":[{"given":"L.","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.L.","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.H.","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.H.","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.J.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.M.","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2012.01.006_bib0005","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.resmic.2007.09.006","article-title":"Genomic diversity in Helicobacter and related organisms","volume":"158","author":"Linz","year":"2007","journal-title":"Res Microbiol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0010","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1056\/NEJM199405053301803","article-title":"Helicobacter pylori infection and gastric lymphoma","volume":"330","author":"Parsonnet","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2012.01.006_bib0015","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc703","article-title":"Helicobacter pylori and gastrointestinal tract adenocarcinomas","volume":"2","author":"Peek","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ijid.2012.01.006_bib0020","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1056\/NEJM199104113241507","article-title":"Helicobacter pylori and peptic ulcer disease","volume":"324","author":"Peterson","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2012.01.006_bib0025","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1056\/NEJMra020542","article-title":"Helicobacter pylori infection","volume":"347","author":"Suerbaum","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2012.01.006_bib0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.femsim.2005.04.002","article-title":"The role of genome diversity and immune evasion in persistent infection with Helicobacter pylori","volume":"45","author":"Cooke","year":"2005","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0035","doi-asserted-by":"crossref","first-page":"15056","DOI":"10.1073\/pnas.251396098","article-title":"Recombination and mutation during long-term gastric colonization by Helicobacter pylori: estimates of clock rates, recombination size, and minimal age","volume":"98","author":"Falush","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijid.2012.01.006_bib0040","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1096\/fj.07-8501com","article-title":"Plastic cells and populations: DNA substrate characteristics in Helicobacter pylori transformation define a flexible but conservative system for genomic variation","volume":"21","author":"Levine","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.ijid.2012.01.006_bib0045","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1523-5378.2008.00642.x","article-title":"Clarithromycin resistance of Helicobacter pylori strains isolated from children\u2019 gastric antrum and fundus as assessed by fluorescent in-situ hybridization and culture on four-sector agar plates","volume":"13","author":"Caristo","year":"2008","journal-title":"Helicobacter"},{"key":"10.1016\/j.ijid.2012.01.006_bib0050","first-page":"296","article-title":"Genotypes of Helicobacter pylori in Lithuanian families","volume":"3","author":"Chalkauskas","year":"1998","journal-title":"Helicobacter"},{"key":"10.1016\/j.ijid.2012.01.006_bib0055","doi-asserted-by":"crossref","first-page":"14625","DOI":"10.1073\/pnas.251551698","article-title":"Helicobacter pylori genetic diversity within the gastric niche of a single human host","volume":"98","author":"Israel","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijid.2012.01.006_bib0060","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1097\/INF.0b013e31817d756e","article-title":"Predominance of mother-to-child transmission of Helicobacter pylori infection detected by random amplified polymorphic DNA fingerprinting analysis in Japanese families","volume":"27","author":"Konno","year":"2008","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.ijid.2012.01.006_bib0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1086\/315173","article-title":"Quasispecies development of Helicobacter pylori observed in paired isolates obtained years apart from the same host","volume":"181","author":"Kuipers","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2012.01.006_bib0070","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1099\/jmm.0.46885-0","article-title":"Helicobacter pylori cag pathogenicity island genotype diversity within the gastric niche of a single host","volume":"56","author":"Matteo","year":"2007","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0075","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1128\/JCM.00273-09","article-title":"Pediatric Helicobacter pylori isolates display distinct gene coding capacities and virulence gene marker profiles","volume":"47","author":"Talarico","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3904\/kjim.2004.19.1.1","article-title":"High prevalence of multiple strain colonization of Helicobacter pylori in Korean patients: DNA diversity among clinical isolates from the gastric corpus, antrum and duodenum","volume":"19","author":"Kim","year":"2004","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.ijid.2012.01.006_bib0085","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/MEG.0b013e3283196af0","article-title":"Helicobacter pylori genotyping findings from multiple cultured isolates and mucosal biopsy specimens: strain diversities of Helicobacter pylori isolates in individual hosts","volume":"21","author":"Kim","year":"2009","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0090","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1099\/jmm.0.011684-0","article-title":"Helicobacter pylori oipA, vacA and dupA genetic diversity in individual hosts","volume":"59","author":"Matteo","year":"2010","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0095","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1128\/JCM.41.7.3336-3338.2003","article-title":"Comparison of genotyping Helicobacter pylori directly from biopsy specimens and genotyping from bacterial cultures","volume":"41","author":"Park","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0100","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1128\/JB.01696-06","article-title":"Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection","volume":"189","author":"Salama","year":"2007","journal-title":"J Bacteriol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0105","series-title":"Current protocols in microbiology","first-page":"622","article-title":"Genetic manipulation of Campylobacter jejuni","author":"Davis","year":"2008"},{"key":"10.1016\/j.ijid.2012.01.006_bib0110","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1093\/nar\/20.19.5137","article-title":"DNA diversity among clinical isolates of Helicobacter pylori detected by PCR-based RAPD fingerprinting","volume":"20","author":"Akopyanz","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ijid.2012.01.006_bib0115","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1126\/science.1080857","article-title":"Traces of human migrations in Helicobacter pylori populations","volume":"299","author":"Falush","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ijid.2012.01.006_bib0120","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1128\/AEM.00894-06","article-title":"Effectiveness of enterobacterial repetitive intergenic consensus PCR and random amplified polymorphic DNA fingerprinting for Helicobacter pylori strain differentiation","volume":"72","author":"Finger","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0125","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1128\/JCM.43.5.2246-2250.2005","article-title":"Five-year follow-up study of mother-to-child transmission of Helicobacter pylori infection detected by a random amplified polymorphic DNA fingerprinting method","volume":"43","author":"Konno","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0130","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1365-2958.2001.02649.x","article-title":"Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells","volume":"42","author":"Backert","year":"2001","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0135","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1158\/1078-0432.CCR-07-2022","article-title":"Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families","volume":"14","author":"Argent","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijid.2012.01.006_bib0140","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nrmicro1528","article-title":"Bacterial populations as perfect gases: genomic integrity and diversification tensions in Helicobacter pylori","volume":"4","author":"Kang","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ijid.2012.01.006_bib0145","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1128\/IAI.00485-06","article-title":"Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori","volume":"74","author":"Colbeck","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijid.2012.01.006_bib0150","doi-asserted-by":"crossref","first-page":"12619","DOI":"10.1073\/pnas.95.21.12619","article-title":"Free recombination within Helicobacter pylori","volume":"95","author":"Suerbaum","year":"1998","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971212000392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971212000392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T14:26:04Z","timestamp":1543155964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971212000392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S1201971212000392"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2012.01.006","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}