{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:51:59Z","timestamp":1792709519899,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T00:00:00Z","timestamp":1389139200000},"content-version":"vor","delay-in-days":221,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.ijid.2013.01.008","type":"journal-article","created":{"date-parts":[[2013,2,23]],"date-time":"2013-02-23T02:13:08Z","timestamp":1361585588000},"page":"e443-e449","source":"Crossref","is-referenced-by-count":94,"title":["Development of a foundation for a case definition of post-treatment Lyme disease syndrome"],"prefix":"10.1016","volume":"17","author":[{"given":"John N.","family":"Aucott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Crowder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen B.","family":"Kortte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2013.01.008_bib0005","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0140-6736(11)60103-7","article-title":"Lyme borreliosis","volume":"379","author":"Stanek","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.ijid.2013.01.008_bib0010","doi-asserted-by":"crossref","first-page":"751","DOI":"10.7326\/0003-4819-142-9-200505030-00011","article-title":"Brief communication: hematogenous dissemination in early Lyme disease","volume":"142","author":"Wormser","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0015","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1056\/NEJMcp061181","article-title":"Clinical practice. Early Lyme disease","volume":"354","author":"Wormser","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0020","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM200107123450207","article-title":"Lyme disease","volume":"345","author":"Steere","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0002-9343(03)00308-5","article-title":"Long-term follow-up of patients with culture-confirmed Lyme disease","volume":"115","author":"Nowakowski","year":"2003","journal-title":"Am J Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0030","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11136-012-0126-6","article-title":"Post-treatment Lyme disease syndrome symptomatology and impact on life functioning: is there something here?","volume":"22","author":"Aucott","year":"2013","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ijid.2013.01.008_bib0035","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/508667","article-title":"The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America","volume":"43","author":"Wormser","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2013.01.008_bib0040","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1161\/01.CIR.0000037745.65929.FA","article-title":"Proceedings of the Jones Criteria workshop","volume":"106","author":"Ferrieri P","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ijid.2013.01.008_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JCM.34.1.1-9.1996","article-title":"Evolution of the serologic response to Borrelia burgdorferi in treated patients with culture-confirmed erythema migrans","volume":"34","author":"Aguero-Rosenfeld","year":"1996","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2013.01.008_bib0050","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/archderm.142.7.862","article-title":"Clinical relevance of different IgG and IgM serum antibody responses to Borrelia burgdorferi after antibiotic therapy for erythema migrans: long-term follow-up study of 113 patients","volume":"142","author":"Glatz","year":"2006","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.ijid.2013.01.008_bib0055","unstructured":"Centers for Disease Control and Prevention. Lyme disease: Two-step Laboratory Testing Process. CDC; 2011. Available at: http:\/\/www.cdc.gov\/lyme\/diagnosistesting\/LabTest\/TwoStep\/."},{"key":"10.1016\/j.ijid.2013.01.008_bib0060","series-title":"How to score Version 2 of the SF-36 Health Survey","author":"Ware","year":"2000"},{"key":"10.1016\/j.ijid.2013.01.008_bib0065","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1056\/NEJM199807233390401","article-title":"Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group","volume":"339","author":"Steere","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.7326\/0003-4819-117-4-273","article-title":"Comparison of cefuroxime axetil and doxycycline in the treatment of early Lyme disease","volume":"117","author":"Nadelman","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0075","first-page":"454","article-title":"Lyme disease: an infectious and postinfectious syndrome","volume":"21","author":"Asch","year":"1994","journal-title":"J Rheumatol"},{"key":"10.1016\/j.ijid.2013.01.008_bib0080","doi-asserted-by":"crossref","first-page":"281","DOI":"10.7326\/0003-4819-117-4-281","article-title":"Lyme disease associated with fibromyalgia","volume":"117","author":"Dinerman","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0085","doi-asserted-by":"crossref","first-page":"919","DOI":"10.7326\/0003-4819-131-12-199912210-00003","article-title":"Musculoskeletal and neurologic outcomes in patients with previously treated Lyme disease","volume":"131","author":"Shadick","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0090","doi-asserted-by":"crossref","first-page":"560","DOI":"10.7326\/0003-4819-121-8-199410150-00002","article-title":"The long-term clinical outcomes of Lyme disease. A population-based retrospective cohort study","volume":"121","author":"Shadick","year":"1994","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0095","doi-asserted-by":"crossref","first-page":"22","DOI":"10.7326\/0003-4819-99-1-22","article-title":"Treatment of the early manifestations of Lyme disease","volume":"99","author":"Steere","year":"1983","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0100","doi-asserted-by":"crossref","first-page":"697","DOI":"10.7326\/0003-4819-138-9-200305060-00005","article-title":"Duration of antibiotic therapy for early Lyme disease. A randomized, double-blind, placebo-controlled trial","volume":"138","author":"Wormser","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0105","doi-asserted-by":"crossref","first-page":"785","DOI":"10.7326\/0003-4819-124-9-199605010-00002","article-title":"Azithromycin compared with amoxicillin in the treatment of erythema migrans. A double-blind, randomized, controlled trial","volume":"124","author":"Luft","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0110","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1056\/NEJM199707313370501","article-title":"Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease","volume":"337","author":"Dattwyler","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0115","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10096-007-0340-2","article-title":"Duration of antibiotic treatment in disseminated Lyme borreliosis: a double-blind, randomized, placebo-controlled, multicenter clinical study","volume":"26","author":"Oksi","year":"2007","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ijid.2013.01.008_bib0120","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1212\/01.WNL.0000068030.26992.25","article-title":"Cognitive function in post-treatment Lyme disease: do additional antibiotics help?","volume":"60","author":"Kaplan","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.ijid.2013.01.008_bib0125","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.amjmed.2009.05.011","article-title":"Subjective symptoms after treatment of early Lyme disease","volume":"123","author":"Cerar","year":"2010","journal-title":"Am J Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0130","doi-asserted-by":"crossref","first-page":"e17287","DOI":"10.1371\/journal.pone.0017287","article-title":"Distinct cerebrospinal fluid proteomes differentiate post-treatment Lyme disease from chronic fatigue syndrome","volume":"6","author":"Schutzer","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2013.01.008_bib0135","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/01.AUD.0000100205.25774.5F","article-title":"Audiologic manifestations of patients with post-treatment Lyme disease syndrome","volume":"24","author":"Shotland","year":"2003","journal-title":"Ear Hear"},{"key":"10.1016\/j.ijid.2013.01.008_bib0140","first-page":"109","article-title":"Retrospective analysis of a cohort of internationally case defined chronic fatigue syndrome patients in a Lyme endemic area","volume":"18","author":"Shore","year":"2011","journal-title":"Bulletin of the IACFS\/ME"},{"key":"10.1016\/j.ijid.2013.01.008_bib0145","doi-asserted-by":"crossref","first-page":"953","DOI":"10.7326\/0003-4819-121-12-199412150-00009","article-title":"The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group","volume":"121","author":"Fukuda","year":"1994","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0150","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3899\/jrheum.110277","article-title":"Toward development of a fibromyalgia responder index and disease activity score: OMERACT module update","volume":"38","author":"Mease","year":"2011","journal-title":"J Rheumatol"},{"key":"10.1016\/j.ijid.2013.01.008_bib0155","doi-asserted-by":"crossref","first-page":"R120","DOI":"10.1186\/ar2783","article-title":"The revised fibromyalgia impact questionnaire (FIQR): validation and psychometric properties","volume":"11","author":"Bennett","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ijid.2013.01.008_bib0160","first-page":"1","article-title":"Association of C-reactive protein and interleukin-6 with new-onset fatigue in the Whitehall II prospective cohort study","author":"Cho","year":"2012","journal-title":"Psychol Med"},{"issue":"6 Suppl 69","key":"10.1016\/j.ijid.2013.01.008_bib0165","first-page":"S97","article-title":"Effectiveness of multidisciplinary therapy on symptomatology and quality of life in women with fibromyalgia","volume":"29","author":"Carbonell-Baeza","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.ijid.2013.01.008_bib0170","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mcna.2006.10.008","article-title":"Behavioral medicine approaches to pain","volume":"91","author":"Okifuji","year":"2007","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.ijid.2013.01.008_bib0175","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pmr.2005.12.004","article-title":"Multidisciplinary and interdisciplinary management of chronic pain","volume":"17","author":"Stanos","year":"2006","journal-title":"Phys Med Rehabil Clin N Am"},{"key":"10.1016\/j.ijid.2013.01.008_bib0180","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.apmr.2010.11.015","article-title":"Evidence-based cognitive rehabilitation: updated review of the literature from 2003 through 2008","volume":"92","author":"Cicerone","year":"2011","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.ijid.2013.01.008_bib0185","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.arr.2010.11.003","article-title":"Cognitive intervention for persons with mild cognitive impairment: a meta-analysis","volume":"10","author":"Li","year":"2011","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.ijid.2013.01.008_bib0190","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1191\/1352458503ms904oa","article-title":"Fatigue associated with multiple sclerosis: diagnosis, impact and management","volume":"9","author":"Bakshi","year":"2003","journal-title":"Mult Scler"},{"key":"10.1016\/j.ijid.2013.01.008_bib0195","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1188\/07.CJON.99-113","article-title":"Putting evidence into practice: evidence-based interventions for fatigue during and following cancer and its treatment","volume":"11","author":"Mitchell","year":"2007","journal-title":"Clin J Oncol Nurs"},{"key":"10.1016\/j.ijid.2013.01.008_bib0200","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1517\/14656566.8.11.1629","article-title":"Treatment of fibromyalgia and its symptoms","volume":"8","author":"Staud","year":"2007","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.ijid.2013.01.008_bib0205","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJM198908313210906","article-title":"Lyme disease","volume":"321","author":"Steere","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2013.01.008_bib0210","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1749-6632.1988.tb31868.x","article-title":"Treatment of erythema chronicum migrans of Lyme disease","volume":"539","author":"Berger","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ijid.2013.01.008_bib0215","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s10067-012-1964-x","article-title":"The amber theory of Lyme arthritis: initial description and clinical implications","volume":"31","author":"Wormser","year":"2012","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.ijid.2013.01.008_bib0220","doi-asserted-by":"crossref","first-page":"e29914","DOI":"10.1371\/journal.pone.0029914","article-title":"Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection","volume":"7","author":"Embers","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2013.01.008_bib0225","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1172\/JCI58813","article-title":"Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy","volume":"122","author":"Bockenstedt","year":"2012","journal-title":"J Clin Invest"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971213000465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971213000465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T19:19:08Z","timestamp":1595445548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971213000465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S1201971213000465"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2013.01.008","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}