{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:33:58Z","timestamp":1768314838942,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["APP1037304"],"award-info":[{"award-number":["APP1037304"]}]},{"name":"Australian National Health and Medical Research Council","award":["APP613671"],"award-info":[{"award-number":["APP613671"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ijid.2017.10.024","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T05:46:55Z","timestamp":1510120015000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Kunitz-type protease inhibitor as a vaccine candidate against schistosomiasis mansoni"],"prefix":"10.1016","volume":"66","author":[{"given":"Shiwanthi L.","family":"Ranasinghe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Duke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Harvie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald P.","family":"McManus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ijid.2017.10.024_bib0005","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1017\/S003118201600069X","article-title":"Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection","volume":"143","author":"Aghazadeh","year":"2016","journal-title":"Parasitology"},{"issue":"6","key":"10.1016\/j.ijid.2017.10.024_bib0010","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s00436-009-1646-z","article-title":"Prime-boost and recombinant protein vaccination strategies using Sm-p80 protects against Schistosoma mansoni infection in the mouse model to levels previously attainable only by the irradiated cercarial vaccine","volume":"105","author":"Ahmad","year":"2009","journal-title":"Parasitol Res"},{"issue":"4","key":"10.1016\/j.ijid.2017.10.024_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005544","article-title":"Quantitative assessment of the impact of partially protective anti-schistosomiasis vaccines","volume":"11","author":"Alsallaq","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"10.1016\/j.ijid.2017.10.024_bib0020","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0169-4758(98)01317-9","article-title":"Cytokine interaction and immune responses during Schistosoma mansoni infection","volume":"14","author":"Brunet","year":"1998","journal-title":"Parasitol Today"},{"issue":"10","key":"10.1016\/j.ijid.2017.10.024_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000308","article-title":"Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection","volume":"2","author":"Cardoso","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"10.1016\/j.ijid.2017.10.024_bib0030","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/nrmicro801","article-title":"Focus: schistosomiasis","volume":"2","author":"Chitsulo","year":"2004","journal-title":"Nat Rev Micro"},{"issue":"1","key":"10.1016\/j.ijid.2017.10.024_bib0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.clim.2008.08.018","article-title":"The effects of IL-6 on CD4 T cell responses","volume":"130","author":"Dienz","year":"2009","journal-title":"Clin Immunol"},{"issue":"1","key":"10.1016\/j.ijid.2017.10.024_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085401","article-title":"Cysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticity","volume":"9","author":"El Ridi","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ijid.2017.10.024_bib0045","first-page":"23","article-title":"Parasitological evaluation of potential candidate vaccines in Schistosoma mansoni-infected mice","volume":"6","author":"Etewa","year":"2014","journal-title":"J Parasitol Vector Biol"},{"key":"10.1016\/j.ijid.2017.10.024_bib0050","series-title":"Challenges in infectious diseases","author":"Fong","year":"2012"},{"key":"10.1016\/j.ijid.2017.10.024_bib0055","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/541268","article-title":"Schistosoma tegument proteins in vaccine and diagnosis development: an update","volume":"2012","author":"Fonseca","year":"2012","journal-title":"J Parasitol Res"},{"issue":"6","key":"10.1016\/j.ijid.2017.10.024_bib0060","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/BF01600304","article-title":"The immunopathology of Schistosoma mansoni granulomas in human colonic schistosomiasis","volume":"416","author":"Geboes","year":"1990","journal-title":"Virchows Archiv A"},{"issue":"2","key":"10.1016\/j.ijid.2017.10.024_bib0065","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.it.2010.11.005","article-title":"To B or not to B: B cells and the Th2-type immune response to helminths","volume":"32","author":"Harris","year":"2011","journal-title":"Trends Immunol"},{"issue":"4","key":"10.1016\/j.ijid.2017.10.024_bib0070","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1586\/14760584.2014.893195","article-title":"Vaccination against helminth parasite infections","volume":"13","author":"Hewitson","year":"2014","journal-title":"Expert Rev Vaccines"},{"issue":"6","key":"10.1016\/j.ijid.2017.10.024_bib0075","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/clpt.2009.16","article-title":"Mass drug administration and integrated control for the world\u2019s high-prevalence neglected tropical diseases","volume":"85","author":"Hotez","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.ijid.2017.10.024_bib0080","series-title":"Concepts in vaccine development","author":"Kaufmann","year":"1996"},{"issue":"6119","key":"10.1016\/j.ijid.2017.10.024_bib0085","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1126\/science.339.6119.502","article-title":"A worm vaccine: coming at a snail\u2019s pace","volume":"339","author":"Kupferschmidt","year":"2013","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.ijid.2017.10.024_bib0090","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1128\/IAI.69.12.7445-7452.2001","article-title":"Role of gamma interferon in the pathogenesis of severe schistosomiasis in interleukin-4-deficient mice","volume":"69","author":"La Flamme","year":"2001","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.ijid.2017.10.024_bib0095","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1128\/CMR.00046-07","article-title":"Current status of vaccines for schistosomiasis","volume":"21","author":"McManus","year":"2008","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"10.1016\/j.ijid.2017.10.024_bib0100","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/1756-3305-7-290","article-title":"Discovery of novel Schistosoma japonicum antigens using a targeted protein microarray approach","volume":"7","author":"McWilliam","year":"2014","journal-title":"Parasit Vectors"},{"issue":"1","key":"10.1016\/j.ijid.2017.10.024_bib0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4269\/ajtmh.13-0467","article-title":"Schistosomiasis elimination strategies and potential role of a vaccine in achieving global health goals","volume":"90","author":"Mo","year":"2014","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"10.1016\/j.ijid.2017.10.024_bib0110","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1086\/314748","article-title":"Cytokine production in acute versus chronic human schistosomiasis mansoni: the cross-regulatory role of interferon-\u03b3 and interleukin-10 in the responses of peripheral blood mononuclear cells and splenocytes to parasite antigens","volume":"179","author":"Montenegro","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2017.10.024_bib0115","doi-asserted-by":"crossref","first-page":"S211","DOI":"10.1017\/S0031182001007703","article-title":"Schistosoma mansoni and Biomphalaria: past history and future trends","author":"Morgan","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/j.ijid.2017.10.024_bib0120","doi-asserted-by":"crossref","first-page":"15069","DOI":"10.1038\/srep15069","article-title":"Lysosome-associated membrane glycoprotein (LAMP)\u2013preliminary study on a hidden antigen target for vaccination against schistosomiasis","volume":"5","author":"Nawaratna","year":"2015","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.ijid.2017.10.024_bib0125","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1128\/IAI.00024-07","article-title":"Gamma interferon responses of CD4 and CD8 T-cell subsets are quantitatively different and independent of each other during pulmonary Mycobacterium bovis BCG infection","volume":"75","author":"Ngai","year":"2007","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.ijid.2017.10.024_bib0130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4269\/ajtmh.2012.11-0204","article-title":"Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil","volume":"86","author":"Oliveira","year":"2012","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"10.1016\/j.ijid.2017.10.024_bib0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001564","article-title":"Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2","volume":"6","author":"Pearson","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijid.2017.10.024_bib0140","series-title":"Nonclinical development of novel biologics, biosimilars, vaccines and specialty biologics","author":"Plitnick","year":"2013"},{"issue":"2","key":"10.1016\/j.ijid.2017.10.024_bib0145","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1590\/S0001-37652011000200025","article-title":"Schistosome serine protease inhibitors: parasite defense or homeostasis?","volume":"83","author":"Quezada","year":"2011","journal-title":"An Acad Bras Cienc"},{"issue":"5","key":"10.1016\/j.ijid.2017.10.024_bib0150","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.pt.2016.12.013","article-title":"Protease Inhibitors of Parasitic Flukes: Emerging Roles in Parasite Survival and Immune Defence","volume":"33","author":"Ranasinghe","year":"2017","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.ijid.2017.10.024_bib0155","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1186\/s13071-015-1022-z","article-title":"Functional expression of a novel Kunitz type protease inhibitor from the human blood fluke Schistosoma mansoni","volume":"8","author":"Ranasinghe","year":"2015","journal-title":"Parasit Vectors"},{"issue":"3","key":"10.1016\/j.ijid.2017.10.024_bib0160","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3390\/vaccines2030654","article-title":"Schistosome vaccine adjuvants in preclinical and clinical research","volume":"2","author":"Stephenson","year":"2014","journal-title":"Vaccines"},{"issue":"1","key":"10.1016\/j.ijid.2017.10.024_bib0165","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1186\/s13071-016-1799-4","article-title":"Schistosomiasis vaccines: where do we stand?","volume":"9","author":"Tebeje","year":"2016","journal-title":"Parasit Vectors"},{"issue":"1","key":"10.1016\/j.ijid.2017.10.024_bib0170","article-title":"IgG antibody and TH1 immune responses to influenza vaccination negatively correlate with M-protein burden in monoclonal gammopathy of undetermined significance","volume":"1","author":"Tete","year":"2013","journal-title":"Hemat Leukemia"},{"issue":"7","key":"10.1016\/j.ijid.2017.10.024_bib0175","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nm1430","article-title":"Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis","volume":"12","author":"Tran","year":"2006","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.ijid.2017.10.024_bib0180","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.icb.7100014","article-title":"Immunopathology of schistosomiasis","volume":"85","author":"Wilson","year":"2007","journal-title":"Immunol Cell Biol"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971217302813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971217302813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:38:25Z","timestamp":1761118705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971217302813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":36,"alternative-id":["S1201971217302813"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2017.10.024","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kunitz-type protease inhibitor as a vaccine candidate against schistosomiasis mansoni","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2017.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}