{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:57:00Z","timestamp":1771660620047,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ijid.2019.03.002","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T21:24:16Z","timestamp":1552080256000},"page":"160-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Fatal Zika virus disease in adults: A critical reappraisal of an under-recognized clinical entity"],"prefix":"10.1016","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-2192","authenticated-orcid":false,"given":"Alfonso J.","family":"Rodr\u00edguez-Morales","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Ram\u00edrez-Vallejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-6361","authenticated-orcid":false,"given":"Lucia Elena","family":"Alvarado-Arnez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-1736","authenticated-orcid":false,"given":"Alberto","family":"Paniz-Mondolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lysien I.","family":"Zambrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert I.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2019.03.002_bib0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12985-018-0938-2","article-title":"Atrial fibrillation in a patient with Zika virus infection","volume":"15","author":"Abdalla","year":"2018","journal-title":"Virol J"},{"key":"10.1016\/j.ijid.2019.03.002_bib0010","doi-asserted-by":"crossref","first-page":"390","DOI":"10.12688\/f1000research.11078.2","article-title":"Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: a systematic review","volume":"6","author":"Alvarez","year":"2017","journal-title":"F1000Res"},{"key":"10.1016\/j.ijid.2019.03.002_bib0015","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/s41467-019-08845-3","article-title":"Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika","volume":"10","author":"Andrade","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijid.2019.03.002_bib0020","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3201\/eid2205.151934","article-title":"Fatal sickle cell disease and Zika virus infection in girl from colombia","volume":"22","author":"Arzuza-Ortega","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.ijid.2019.03.002_bib0025","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jcv.2016.10.024","article-title":"Zika virus epidemic in Brazil. I. Fatal disease in adults: clinical and laboratorial aspects","volume":"85","author":"Azevedo","year":"2016","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ijid.2019.03.002_bib0030","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.4269\/ajtmh.16-0306","article-title":"Guillain\u2013Barre syndrome after Zika virus infection in Brazil","volume":"95","author":"do Rosario","year":"2016","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ijid.2019.03.002_bib0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jcv.2015.05.021","article-title":"Fatal cases of Chikungunya virus infection in Colombia: diagnostic and treatment challenges","volume":"69","author":"Hoz","year":"2015","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ijid.2019.03.002_bib0040","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ebiom.2016.09.022","article-title":"Characterization of a 2016 clinical isolate of Zika virus in non-human primates","author":"Li","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ijid.2019.03.002_bib0045","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tmaid.2015.07.005","article-title":"A bibliometric analysis of global Zika research","volume":"14","author":"Martinez-Pulgarin","year":"2016","journal-title":"Travel Med Infect Dis"},{"key":"10.1016\/j.ijid.2019.03.002_bib0050","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jcv.2018.03.009","article-title":"Renal involvement in fatal cases of Chikungunya virus infection","volume":"103","author":"Mercado","year":"2018","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ijid.2019.03.002_bib0055","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1017\/S095026881800359X","article-title":"Dengue, Chikungunya and Zika virus coinfection: results of the national surveillance during the Zika epidemic in Colombia","volume":"147","author":"Mercado-Reyes","year":"2019","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.ijid.2019.03.002_bib0060","first-page":"e1399","article-title":"Association of Zika virus with myocarditis, heart failure, and arrhythmias: a literature review","volume":"9","author":"Minhas","year":"2017","journal-title":"Cureus"},{"key":"10.1016\/j.ijid.2019.03.002_bib0065","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jamapediatrics.2016.3982","article-title":"Characterizing the pattern of anomalies in congenital Zika syndrome for pediatric clinicians","volume":"171","author":"Moore","year":"2017","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.ijid.2019.03.002_bib0070","doi-asserted-by":"crossref","first-page":"e355","DOI":"10.1016\/S1473-3099(18)30269-X","article-title":"Unexpected outbreaks of arbovirus infections: lessons learned from the Pacific and tropical America","volume":"18","author":"Musso","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijid.2019.03.002_bib0075","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.4269\/ajtmh.17-0250","article-title":"Fatal Leptospira spp.\/Zika virus coinfection-Puerto Rico, 2016","volume":"97","author":"Neaterour","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ijid.2019.03.002_bib0080","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev-immunol-042617-053142","article-title":"Immune response to dengue and Zika","volume":"36","author":"Ngono","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ijid.2019.03.002_bib0085","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cmi.2017.11.004","article-title":"Adverse birth outcomes associated with Zika virus exposure during pregnancy in Sao Jose do Rio Preto, Brazil","volume":"24","author":"Nogueira","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijid.2019.03.002_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijid.2019.01.047","article-title":"Postmortem evidence of disseminated Zika virus infection in an adult patient","author":"Rajahram","year":"2019","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.ijid.2019.03.002_bib0095","doi-asserted-by":"crossref","DOI":"10.1177\/1076029618821184","article-title":"Zika and Chikungunya virus and risk for venous thromboembolism","volume":"25","author":"Ramacciotti","year":"2019","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.ijid.2019.03.002_bib0100","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika virus and birth defects\u2014reviewing the evidence for causality","volume":"374","author":"Rasmussen","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2019.03.002_bib0105","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.aav6618","article-title":"Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region","volume":"363","author":"Rodriguez-Barraquer","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.ijid.2019.03.002_bib0110","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijid.2018.04.3856","article-title":"Postnatal acquired fatal Zika virus infection in the Americas: a systematic review","volume":"73","author":"Rodriguez-Morales","year":"2018","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.ijid.2019.03.002_bib0115","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3855\/jidc.7230","article-title":"Zika: the new arbovirus threat for Latin America","volume":"9","author":"Rodriguez-Morales","year":"2015","journal-title":"J Infect Dev Ctries"},{"key":"10.1016\/j.ijid.2019.03.002_bib0120","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijid.2018.04.3587","article-title":"Severe, atypical and fatal cases of Zika virus infection: experience in Colombia","volume":"73","author":"Rodriguez-Morales","year":"2018","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.ijid.2019.03.002_bib0125","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1128\/JCM.00877-16","article-title":"Coinfections of Zika and Chikungunya viruses in Bahia, Brazil, identified by metagenomic next-generation sequencing","volume":"54","author":"Sardi","year":"2016","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2019.03.002_bib0130","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S1473-3099(16)30006-8","article-title":"Zika virus associated deaths in Colombia","volume":"16","author":"Sarmiento-Ospina","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijid.2019.03.002_bib0135","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.mayocp.2016.12.019","article-title":"Zika virus meningoencephalitis in an immunocompromised patient","volume":"92","author":"Schwartzmann","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ijid.2019.03.002_bib0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jcv.2016.08.297","article-title":"Fatal encephalitis associated with Zika virus infection in an adult","volume":"83","author":"Soares","year":"2016","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ijid.2019.03.002_bib0145","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.tmaid.2016.06.004","article-title":"Electrocardiographic alterations in patients with chikungunya fever from Sucre, Colombia: a 42-case series","volume":"14","author":"Villamil-Gomez","year":"2016","journal-title":"Travel Med Infect Dis"},{"key":"10.1016\/j.ijid.2019.03.002_bib0150","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijid.2016.07.017","article-title":"Zika, dengue, and chikungunya co-infection in a pregnant woman from Colombia","volume":"51","author":"Villamil-Gomez","year":"2016","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.ijid.2019.03.002_bib0155","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.mayocp.2017.12.006","article-title":"Cardiac compromise in Zika virus infection","volume":"93","author":"Villamil-Gomez","year":"2018","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ijid.2019.03.002_bib0160","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.antiviral.2016.03.010","article-title":"Zika virus: history, emergence, biology, and prospects for control","volume":"130","author":"Weaver","year":"2016","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ijid.2019.03.002_bib0165","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.idcr.2016.07.009","article-title":"Three atypical lethal cases associated with acute Zika virus infection in Suriname","volume":"5","author":"Zonneveld","year":"2016","journal-title":"IDCases"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971219301298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971219301298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:45:02Z","timestamp":1761119102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971219301298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":33,"alternative-id":["S1201971219301298"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2019.03.002","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fatal Zika virus disease in adults: A critical reappraisal of an under-recognized clinical entity","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2019.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}