{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:36:41Z","timestamp":1782819401649,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201400006C"],"award-info":[{"award-number":["HHSN272201400006C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702079"],"award-info":[{"award-number":["81702079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672014"],"award-info":[{"award-number":["81672014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["HHSN272201400006C"],"award-info":[{"award-number":["HHSN272201400006C"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.ijid.2020.01.017","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T12:17:27Z","timestamp":1579609047000},"page":"208-213","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Influenza A-associated severe pneumonia in hospitalized patients: Risk factors and NAI treatments"],"prefix":"10.1016","volume":"92","author":[{"given":"Qianda","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufa","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2171-4710","authenticated-orcid":false,"given":"Tieli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-6279","authenticated-orcid":false,"given":"Dhanasekaran","family":"Vijaykrishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4560-8434","authenticated-orcid":false,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijid.2020.01.017_bib0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/s13054-016-1512-1","article-title":"Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome","volume":"20","author":"Alvarez-Lerma","year":"2016","journal-title":"Crit Care."},{"issue":"46","key":"10.1016\/j.ijid.2020.01.017_bib0010","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2015.20.46.30066","article-title":"Intensive care unit surveillance of influenza infection in France: the 2009\/10 pandemic and the three subsequent seasons","volume":"20","author":"Bonmarin","year":"2015","journal-title":"Euro Surveill."},{"key":"10.1016\/j.ijid.2020.01.017_bib0015","unstructured":"Chinese National Influenza Center. Chinese influenza surveillance report. Available from: http:\/\/www.chinaivdc.cn\/cnic\/zyzx\/lgzb\/201802\/t20180202_158647\/ accessed 27 October 2019."},{"issue":"10","key":"10.1016\/j.ijid.2020.01.017_bib0020","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1099\/jmm.0.000593","article-title":"Outcomes of patients with severe influenza infection admitted to intensive care units: a retrospective study in a medical centre","volume":"66","author":"Chao","year":"2017","journal-title":"J Med Microbiol"},{"issue":"1","key":"10.1016\/j.ijid.2020.01.017_bib0025","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13054-019-2491-9","article-title":"Influenza virus-related critical illness: prevention, diagnosis, treatment","volume":"23","author":"Chow","year":"2019","journal-title":"Crit Care."},{"issue":"12","key":"10.1016\/j.ijid.2020.01.017_bib0030","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1093\/cid\/ciu632","article-title":"Evaluation of intravenous peramivir for treatment of influenza in hospitalized patients","volume":"59","author":"de Jong","year":"2014","journal-title":"Clin Infect Dis."},{"issue":"7","key":"10.1016\/j.ijid.2020.01.017_bib0035","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3851\/IMP2807","article-title":"A randomized study of standard versus double dose oseltamivir for treating influenza in the community","volume":"20","author":"Dixit","year":"2015","journal-title":"Antivir Ther."},{"issue":"11","key":"10.1016\/j.ijid.2020.01.017_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000362","article-title":"Efficacy of oseltamivir-zanamivir combination compared to each monotherapy for seasonal influenza: a randomized placebo-controlled trial","volume":"7","author":"Duval","year":"2010","journal-title":"Plos Med."},{"issue":"2","key":"10.1016\/j.ijid.2020.01.017_bib0045","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.antiviral.2012.08.002","article-title":"Oseltamivir-zanamivir bitherapy compared to oseltamivir monotherapy in the treatment of pandemic 2009 influenza A(H1N1) virus infections","volume":"96","author":"Escuret","year":"2012","journal-title":"Antiviral Res."},{"issue":"1","key":"10.1016\/j.ijid.2020.01.017_bib0050","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1186\/s12879-019-4181-2","article-title":"Clinical characteristics and outcomes during a severe influenza season in China during 2017\u20132018","volume":"19","author":"Fu","year":"2019","journal-title":"BMC Infect Dis."},{"issue":"1","key":"10.1016\/j.ijid.2020.01.017_bib0055","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S2213-2600(18)30496-X","article-title":"Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017","volume":"7","author":"GBD 2017 Influenza Collaborators","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"4","key":"10.1016\/j.ijid.2020.01.017_bib0060","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1128\/AAC.01312-06","article-title":"Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus","volume":"51","author":"Govorkova","year":"2007","journal-title":"Antimicrob Agents Chemother."},{"issue":"34","key":"10.1016\/j.ijid.2020.01.017_bib0065","first-page":"429","article-title":"Review of 2017-18 influenza season in the northern hemisphere","volume":"93","author":"Hammond","year":"2018","journal-title":"Weekly Epidemiological Record."},{"issue":"10","key":"10.1016\/j.ijid.2020.01.017_bib0070","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMoa1716197","article-title":"Baloxavir marboxil for uncomplicated influenza in adults and adolescents","volume":"379","author":"Hayden","year":"2018","journal-title":"N Engl J Med."},{"issue":"6","key":"10.1016\/j.ijid.2020.01.017_bib0075","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3201\/eid2206.151037","article-title":"Debate regarding Oseltamivir use for seasonal and pandemic influenza","volume":"22","author":"Hurt","year":"2016","journal-title":"Emerg Infect Dis."},{"issue":"4","key":"10.1016\/j.ijid.2020.01.017_bib0080","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3851\/IMP2680","article-title":"Intravenous peramivir for treatment of influenza in hospitalized patients","volume":"19","author":"Ison","year":"2014","journal-title":"Antivir Ther."},{"issue":"6","key":"10.1016\/j.ijid.2020.01.017_bib0085","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.ajpath.2014.08.030","article-title":"The role of viral, host, and secondary bacterial factors in influenza pathogenesis","volume":"185","author":"Kash","year":"2015","journal-title":"Am J Pathol."},{"key":"10.1016\/j.ijid.2020.01.017_bib0090","series-title":"Programs and abstracts of the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (Denver)","first-page":"1470","article-title":"ROSII Study Investigators. Viral clearance with standard or triple dose oseltamivir therapy in critically ill patients with pandemic (H1N1) 2009 influenza","author":"Kumar","year":"2013"},{"issue":"4","key":"10.1016\/j.ijid.2020.01.017_bib0095","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1086\/600383","article-title":"Viral loads and duration of viral shedding in adult patients hospitalized with influenza","volume":"200","author":"Lee","year":"2009","journal-title":"J Infect Dis."},{"issue":"11","key":"10.1016\/j.ijid.2020.01.017_bib0100","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/cid\/cit597","article-title":"A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza A and B infections","volume":"57","author":"Lee","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"8","key":"10.1016\/j.ijid.2020.01.017_bib0105","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.3201\/eid1608.091918","article-title":"Correlation of pandemic (H1N1) 2009 viral load with disease severity and prolonged viral shedding in children","volume":"16","author":"Li","year":"2010","journal-title":"Emerg Infect Dis"},{"issue":"Suppl 2","key":"10.1016\/j.ijid.2020.01.017_bib0110","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/511159","article-title":"Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults","volume":"44","author":"Mandell","year":"2007","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.ijid.2020.01.017_bib0115","doi-asserted-by":"crossref","first-page":"f5061","DOI":"10.1136\/bmj.f5061","article-title":"Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis","volume":"347","author":"Mertz","year":"2013","journal-title":"BMJ."},{"issue":"10","key":"10.1016\/j.ijid.2020.01.017_bib0120","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1177\/0885066616638649","article-title":"Comparison of high-dose versus standard dose Oseltamivir in critically ill patients with influenza","volume":"32","author":"Noel","year":"2017","journal-title":"J Intensive Care Med."},{"issue":"10095","key":"10.1016\/j.ijid.2020.01.017_bib0125","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0140-6736(17)30129-0","article-title":"Influenza","volume":"390","author":"Paules","year":"2017","journal-title":"Lancet"},{"issue":"4 Suppl","key":"10.1016\/j.ijid.2020.01.017_bib0130","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1097\/CCM.0b013e3181c92eeb","article-title":"Complications of seasonal and pandemic influenza","volume":"38","author":"Rothberg","year":"2010","journal-title":"Crit Care Med"},{"issue":"11","key":"10.1016\/j.ijid.2020.01.017_bib0135","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1017\/ice.2015.170","article-title":"Severe influenza in 33 US hospitals, 2013-2014: complications and risk factors for death in 507 patients","volume":"36","author":"Shah","year":"2015","journal-title":"Infect Control Hosp Epidemiol."},{"issue":"1","key":"10.1016\/j.ijid.2020.01.017_bib0140","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1473-3099(13)70286-X","article-title":"Pathogenesis of influenza-induced acute respiratory distress syndrome","volume":"14","author":"Short","year":"2014","journal-title":"Lancet Infect Dis."},{"issue":"8","key":"10.1016\/j.ijid.2020.01.017_bib0145","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA."},{"key":"10.1016\/j.ijid.2020.01.017_bib0150","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.f3039","article-title":"Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial","volume":"346","author":"South East Asia Infectious Disease Clinical Research Network","year":"2013","journal-title":"BMJ"},{"issue":"11","key":"10.1016\/j.ijid.2020.01.017_bib0155","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1093\/infdis\/jiy115","article-title":"Factors associated with prolonged viral shedding in patients with avian influenza A(H7N9) virus infection","volume":"217","author":"Wang","year":"2018","journal-title":"J Infect Dis."},{"key":"10.1016\/j.ijid.2020.01.017_bib0160","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2147\/IDR.S86460","article-title":"Peramivir injection in the treatment of acute influenza: a review of the literature","volume":"9","author":"Wester","year":"2016","journal-title":"Infect Drug Resist."},{"key":"10.1016\/j.ijid.2020.01.017_bib0165","series-title":"WHO Guidelines for Pharmacological Management of Pandemic Influenza A(H1N1) 2009 and Other Influenza Viruses","author":"World Health Organization","year":"2010"},{"key":"10.1016\/j.ijid.2020.01.017_bib0170","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12879-016-1383-8","article-title":"Efficacy of oseltamivir-peramivir combination therapy compared to oseltamivir monotherapy for Influenza A (H7N9) infection: a retrospective study","volume":"16","author":"Zhang","year":"2016","journal-title":"BMC Infect Dis."},{"key":"10.1016\/j.ijid.2020.01.017_bib0175","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jcv.2019.06.005","article-title":"Seasonal influenza-associated intensive care unit admission and death in tropical Singapore, 2011-2015","volume":"117","author":"Zhang","year":"2019","journal-title":"J Clin Virol."}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971220300199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971220300199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:24:31Z","timestamp":1778592271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971220300199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":35,"alternative-id":["S1201971220300199"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2020.01.017","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influenza A-associated severe pneumonia in hospitalized patients: Risk factors and NAI treatments","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2020.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}