{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:07:45Z","timestamp":1781302065566,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Agency for Science and Technology Promotion"},{"name":"CONICET), R"},{"name":"esearch Career Program"},{"name":"Ferressini Gerpe,"},{"name":"ANPCyT)"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.ijid.2020.01.044","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T16:18:55Z","timestamp":1580228335000},"page":"139-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Distinctive EBV infection characteristics in children from a developing country"],"prefix":"10.1016","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-3085","authenticated-orcid":false,"given":"N.M.","family":"Ferressini Gerpe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.","family":"Vistarop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Moyano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"De Matteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.V.","family":"Preciado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7355-3859","authenticated-orcid":false,"given":"P.A.","family":"Chabay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.ijid.2020.01.044_bib0005","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00382-17","article-title":"Asymptomatic primary infection with Epstein-Barr virus: observations on young adult cases","volume":"91","author":"Abbott","year":"2017","journal-title":"J Virol"},{"issue":"22","key":"10.1016\/j.ijid.2020.01.044_bib0010","doi-asserted-by":"crossref","first-page":"12250","DOI":"10.1073\/pnas.200366597","article-title":"Tonsillar memory B cells, latently infected with Epstein-Barr virus, express the restricted pattern of latent genes previously found only in Epstein-Barr virus-associated tumors","volume":"97","author":"Babcock","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.ijid.2020.01.044_bib0015","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1038\/cti.2015.1","article-title":"Infectious mononucleosis","volume":"4","author":"Balfour","year":"2015","journal-title":"Clin Transl Immunol"},{"key":"10.1016\/j.ijid.2020.01.044_bib0020","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fimmu.2019.00146","article-title":"Revisiting the tissue microenvironment of infectious mononucleosis: identification of EBV infection in T cells and deep characterization of immune profiles","volume":"10","author":"Barros","year":"2019","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.ijid.2020.01.044_bib0025","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/ijc.27845","article-title":"Epstein-Barr virus presence in pediatric diffuse large B-cell lymphoma reveals a particular association and latency patterns: analysis of viral role in tumor microenvironment","volume":"132","author":"Cohen","year":"2013","journal-title":"Int J Cancer"},{"issue":"6","key":"10.1016\/j.ijid.2020.01.044_bib0030","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/infdis\/jix363","article-title":"Epstein-Barr virus type 2 infects T cells in healthy Kenyan Children","volume":"216","author":"Coleman","year":"2017","journal-title":"J Infect Dis"},{"issue":"21","key":"10.1016\/j.ijid.2020.01.044_bib0035","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00813-18","article-title":"Epstein-Barr virus type 2 infects T cells and induces B cell lymphomagenesis in Humanized Mice","volume":"92","author":"Coleman","year":"2018","journal-title":"J Virol"},{"issue":"6","key":"10.1016\/j.ijid.2020.01.044_bib0040","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/ijc.27858","article-title":"EBV primary infection in childhood and its relation to B-cell lymphoma development: a mini-review from a developing region","volume":"133","author":"Chabay","year":"2013","journal-title":"Int J Cancer"},{"issue":"12","key":"10.1016\/j.ijid.2020.01.044_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005286","article-title":"The incubation period of primary Epstein-Barr virus infection: viral dynamics and immunologic events","volume":"11","author":"Dunmire","year":"2015","journal-title":"PLoS Pathog"},{"issue":"2","key":"10.1016\/j.ijid.2020.01.044_bib0050","first-page":"110","article-title":"Epstein-Barr virus load in transplant patients: Early detection of post-transplant lymphoproliferative disorders","volume":"48","author":"Fellner","year":"2016","journal-title":"Rev Argent Microbiol"},{"issue":"2\u20133","key":"10.1016\/j.ijid.2020.01.044_bib0055","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s12026-014-8496-1","article-title":"The interplay between Epstein-Barr virus and B lymphocytes: implications for infection, immunity, and disease","volume":"58","author":"Hatton","year":"2014","journal-title":"Immunol Res"},{"issue":"4","key":"10.1016\/j.ijid.2020.01.044_bib0060","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/modpathol.3800369","article-title":"Distribution and phenotype of Epstein-Barr virus-infected cells in human pharyngeal tonsils","volume":"18","author":"Hudnall","year":"2005","journal-title":"Modern Pathol"},{"issue":"3","key":"10.1016\/j.ijid.2020.01.044_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004746","article-title":"Early virological and immunological events in asymptomatic Epstein-Barr virus infection in African children","volume":"11","author":"Jayasooriya","year":"2015","journal-title":"PLoS Pathog"},{"issue":"4","key":"10.1016\/j.ijid.2020.01.044_bib0070","doi-asserted-by":"crossref","first-page":"6130","DOI":"10.18632\/oncotarget.14045","article-title":"Tonsillar CD56brightNKG2A+ NK cells restrict primary Epstein-Barr virus infection in B cells via IFN-gamma","volume":"8","author":"Jud","year":"2017","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.ijid.2020.01.044_bib0075","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1128\/JCM.00164-09","article-title":"Evidence-based approach for interpretation of Epstein-Barr virus serological patterns","volume":"47","author":"Klutts","year":"2009","journal-title":"J Clin Microbiol"},{"issue":"10","key":"10.1016\/j.ijid.2020.01.044_bib0080","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nri1201","article-title":"B cells under influence: transformation of B cells by Epstein-Barr virus","volume":"3","author":"Kuppers","year":"2003","journal-title":"Na Rev Immunol"},{"issue":"8","key":"10.1016\/j.ijid.2020.01.044_bib0085","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1073\/pnas.2627966100","article-title":"Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction","volume":"100","author":"Kurth","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.ijid.2020.01.044_bib0090","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S1074-7613(00)00048-0","article-title":"EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency","volume":"13","author":"Kurth","year":"2000","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.ijid.2020.01.044_bib0095","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1136\/mp.54.4.264","article-title":"Epstein-Barr virus infection in paediatric liver transplant recipients: detection of the virus in post-transplant tonsillectomy specimens","volume":"54","author":"Meru","year":"2001","journal-title":"Mol Pathol: MP"},{"issue":"2","key":"10.1016\/j.ijid.2020.01.044_bib0100","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1096-9896(199706)182:2<151::AID-PATH824>3.0.CO;2-3","article-title":"Epstein-Barr virus (EBV) infection in infectious mononucleosis: virus latency, replication and phenotype of EBV-infected cells","volume":"182","author":"Niedobitek","year":"1997","journal-title":"J Pathol"},{"issue":"1","key":"10.1016\/j.ijid.2020.01.044_bib0105","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/mp.53.1.37","article-title":"Epstein-Barr virus (EBV) in infectious mononucleosis: detection of the virus in tonsillar B lymphocytes but not in desquamated oropharyngeal epithelial cells","volume":"53","author":"Niedobitek","year":"2000","journal-title":"Mol Pathol: MP"},{"issue":"6","key":"10.1016\/j.ijid.2020.01.044_bib0110","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1093\/infdis\/jir872","article-title":"Early age at time of primary Epstein-Barr virus infection results in poorly controlled viral infection in infants from Western Kenya: clues to the etiology of endemic Burkitt lymphoma","volume":"205","author":"Piriou","year":"2012","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.ijid.2020.01.044_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004656","article-title":"To be or not IIb: a multi-step process for Epstein-Barr virus latency establishment and consequences for B cell tumorigenesis","volume":"11","author":"Price","year":"2015","journal-title":"PLoS Pathogens"},{"issue":"2","key":"10.1016\/j.ijid.2020.01.044_bib0120","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1128\/JVI.01780-09","article-title":"Germinal center B cells latently infected with Epstein-Barr virus proliferate extensively but do not increase in number","volume":"84","author":"Roughan","year":"2010","journal-title":"J Virol"},{"issue":"9","key":"10.1016\/j.ijid.2020.01.044_bib0125","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1128\/jvi.64.9.4084-4092.1990","article-title":"Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes","volume":"64","author":"Sample","year":"1990","journal-title":"J Virol"},{"issue":"6","key":"10.1016\/j.ijid.2020.01.044_bib0130","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/jmv.24737","article-title":"EBV infection is prevalent in the adenoid and palatine tonsils in adults","volume":"89","author":"Seishima","year":"2017","journal-title":"J Med Virol"},{"issue":"1732","key":"10.1016\/j.ijid.2020.01.044_bib0135","article-title":"Epstein-Barr virus-associated lymphomas","volume":"372","author":"Shannon-Lowe","year":"2017","journal-title":"Philos Trans R Soc London B, Biolog Sci"},{"issue":"12","key":"10.1016\/j.ijid.2020.01.044_bib0140","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1093\/infdis\/jit093","article-title":"Clinical and virologic manifestations of primary Epstein-Barr virus (EBV) infection in Kenyan infants born to HIV-infected women","volume":"207","author":"Slyker","year":"2013","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.ijid.2020.01.044_bib0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006890","article-title":"Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naive B cells, and facilitates recruitment of transcription factors to the viral genome","volume":"14","author":"Szymula","year":"2018","journal-title":"PLoS Pathog"},{"issue":"Pt 1","key":"10.1016\/j.ijid.2020.01.044_bib0150","first-page":"151","article-title":"EBV Persistence\u2013introducing the virus","volume":"390","author":"Thorley-Lawson","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"issue":"4","key":"10.1016\/j.ijid.2020.01.044_bib0155","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.it.2008.01.006","article-title":"Epstein-Barr virus: a paradigm for persistent infection \u2013 for real and in virtual reality","volume":"29","author":"Thorley-Lawson","year":"2008","journal-title":"Trends Immunol"},{"issue":"13","key":"10.1016\/j.ijid.2020.01.044_bib0160","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1056\/NEJMra032015","article-title":"Persistence of the Epstein-Barr virus and the origins of associated lymphomas","volume":"350","author":"Thorley-Lawson","year":"2004","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.ijid.2020.01.044_bib0165","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.coviro.2013.04.005","article-title":"The pathogenesis of Epstein-Barr virus persistent infection","volume":"3","author":"Thorley-Lawson","year":"2013","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.ijid.2020.01.044_bib0170","doi-asserted-by":"crossref","first-page":"23303","DOI":"10.1038\/srep23303","article-title":"Analysis of Epstein-Barr virus infection models in a series of pediatric carriers from a developing country","volume":"6","author":"Vistarop","year":"2016","journal-title":"Sci Rep"},{"issue":"33","key":"10.1016\/j.ijid.2020.01.044_bib0175","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1038\/sj.onc.1206556","article-title":"Epstein-Barr virus and oncogenesis: from latent genes to tumours","volume":"22","author":"Young","year":"2003","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.ijid.2020.01.044_bib0180","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrc1452","article-title":"Epstein-Barr virus: 40 years on","volume":"4","author":"Young","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"12","key":"10.1016\/j.ijid.2020.01.044_bib0185","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrc.2016.92","article-title":"Epstein-Barr virus: more than 50 years old and still providing surprises","volume":"16","author":"Young","year":"2016","journal-title":"Nat Rev Cancer"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971220300473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971220300473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:48:54Z","timestamp":1761119334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971220300473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":37,"alternative-id":["S1201971220300473"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2020.01.044","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinctive EBV infection characteristics in children from a developing country","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2020.01.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}