{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:31:38Z","timestamp":1770751898023,"version":"3.50.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EU Horizon 2020 Framework Programme for Research and Innovation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.ijid.2020.02.011","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T03:06:00Z","timestamp":1582859160000},"page":"S69-S71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"S","title":["Advancing new diagnostic tests for latent tuberculosis infection due to multidrug-resistant strains of Mycobacterium tuberculosis \u2014 End of the road?"],"prefix":"10.1016","volume":"92","author":[{"given":"Peter","family":"Mwaba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremiah Muhwa","family":"Chakaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eskild","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Wejse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alimuddin","family":"Zumla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Kapata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2020.02.011_bib0005","doi-asserted-by":"crossref","DOI":"10.1111\/apm.13025","article-title":"Comparative evaluation of CLIA and EIA for Quantiferon-TB Gold Plus","author":"Brantestig","year":"2020","journal-title":"APMIS"},{"issue":"3","key":"10.1016\/j.ijid.2020.02.011_bib0010","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00655-2019","article-title":"The global prevalence of latent tuberculosis: a systematic review and meta-analysis","volume":"54","author":"Cohen","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ijid.2020.02.011_bib0015","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijid.2019.12.012","article-title":"LIOFeron\u00aeTB\/LTBI: a novel and reliable test for LTBI and tuberculosis","volume":"91","author":"Della Bella","year":"2020","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.ijid.2020.02.011_bib0020","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2147\/IDR.S184640","article-title":"The blood transcriptional signature for active and latent tuberculosis","volume":"12","author":"Deng","year":"2019","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.ijid.2020.02.011_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-2600(19)30282-6","article-title":"Concise whole blood transcriptional signatures for incipient tuberculosis: a systematic review and patient-level pooled meta-analysis","author":"Gupta","year":"2020","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.ijid.2020.02.011_bib0030","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.ccm.2019.07.007","article-title":"Diagnostic tests for latent TB infection","volume":"40","author":"Haas","year":"2019","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.ijid.2020.02.011_bib0035","article-title":"Identifying gaps in the quality of latent tuberculosis infection care","volume":"18","author":"Alsdurf","year":"2020","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"issue":"10","key":"10.1016\/j.ijid.2020.02.011_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002152","article-title":"The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling","volume":"13","author":"Houben","year":"2016","journal-title":"PLoS Med"},{"key":"10.1016\/j.ijid.2020.02.011_bib0045","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ccm.2019.07.008","article-title":"Treatment of Latent Tb Infection\u2014an update","volume":"40","author":"Huaman","year":"2019","journal-title":"Clin Chest Med"},{"issue":"8","key":"10.1016\/j.ijid.2020.02.011_bib0050","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1473-3099(19)30307-X","article-title":"Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling","volume":"19","author":"Knight","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijid.2020.02.011_bib0055","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciz1221","article-title":"Two clinical prediction tools to improve tuberculosis contact investigation","author":"Li","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.1016\/j.ijid.2020.02.011_bib0060","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/infdis\/jiy579","article-title":"Anatomic and cellular niches for Mycobacterium tuberculosis in latent tuberculosis infection","volume":"219","author":"Mayito","year":"2019","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2020.02.011_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijid.2020.01.042","article-title":"MDR\/XDR-TB management of patients and contacts: challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network","author":"Migliori","year":"2020","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.ijid.2020.02.011_bib0070","unstructured":"McGill University ref. www.tstin3d.com.16. [Accessed 22 January 2020]."},{"issue":"3","key":"10.1016\/j.ijid.2020.02.011_bib0075","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1473-3099(19)30059-3","article-title":"Latent tuberculosis infection: diagnostic tests and when to treat","volume":"19","author":"Petersen","year":"2019","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"10.1016\/j.ijid.2020.02.011_bib0080","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S2213-2600(16)30436-2","article-title":"Safety and efficacy of the C-Tb skin test to diagnose Mycobacterium tuberculosis infection, compared with an interferon gamma release assay and the tuberculin skin test: a phase 3, double-blind, randomised, controlled trial","volume":"5","author":"Ruhwald","year":"2017","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.ijid.2020.02.011_bib0085","article-title":"Differential expression of activation markers by Mycobacterium tuberculosis-specific CD4+ T-cell distinguishes extrapulmonary from pulmonary tuberculosis and latent infection","author":"Silveira-Mattos","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"9","key":"10.1016\/j.ijid.2020.02.011_bib0090","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1164\/rccm.201711-2340OC","article-title":"Four-gene Pan-African blood signature predicts progres-sion to tuberculosis","volume":"197","author":"Suliman","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ijid.2020.02.011_bib0095","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.3389\/fimmu.2019.02948","article-title":"Transcriptional profiling of human peripheral blood mononuclear cells identifies diagnostic biomarkers that distinguish active and latent tuberculosis","volume":"10","author":"Wang","year":"2019","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.ijid.2020.02.011_bib0100","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.3779","article-title":"Assess-ment of validity of a blood-based 3-gene signature score for progression and diagnosis of tuberculosis, disease severity, and treatment response","volume":"1","author":"Warsinske","year":"2018","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ijid.2020.02.011_bib0105","series-title":"Latent tuberculosis infection: updated and consolidated guidelines for programmatic management","author":"WHO","year":"2019"},{"key":"10.1016\/j.ijid.2020.02.011_bib0110","series-title":"Latent TB infection: updated and consolidated guidelines for programmatic management","author":"WHO","year":"2020"},{"key":"10.1016\/j.ijid.2020.02.011_bib0115","series-title":"WHO 2020: LTBI care: a mobile app to support programmatic management of LTBI","author":"WHO","year":"2020"},{"key":"10.1016\/j.ijid.2020.02.011_bib0120","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01854-19","article-title":"Comparative results of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus assays for tuberculosis diagnosis of clinical samples","author":"Won","year":"2020","journal-title":"J Clin Microbiol"},{"issue":"10035","key":"10.1016\/j.ijid.2020.02.011_bib0125","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/S0140-6736(15)01316-1","article-title":"A blood RNA signature for tuberculosis disease risk: a prospective cohort study","volume":"387","author":"Zak","year":"2016","journal-title":"Lancet"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971220300692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971220300692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:48:43Z","timestamp":1761119323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971220300692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":25,"alternative-id":["S1201971220300692"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2020.02.011","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancing new diagnostic tests for latent tuberculosis infection due to multidrug-resistant strains of Mycobacterium tuberculosis \u2014 End of the road?","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2020.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}